Fulan Guan, PhD
Associate Research Scientist in Pharmacology; Visiting Research Scientist
Research & Publications
Biography
News
Coauthors
Selected Publications
- YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironmentYang X, Lam W, Jiang Z, Guan F, Han X, Hu R, Cai W, Cheng W, Liu SH, Cheng P, Cai Y, Rattray NJW, Johnson CH, Chen L, Cheng YC. YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment. Scientific Reports 2021, 11: 13482. PMID: 34188068, PMCID: PMC8242098, DOI: 10.1038/s41598-021-91623-3.
- Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in ChinaWu J, Sun B, Hou L, Guan F, Wang L, Cheng P, Scobell S, Cheng YC, Lam W. Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China. Frontiers In Pharmacology 2021, 11: 615287. PMID: 33716728, PMCID: PMC7947616, DOI: 10.3389/fphar.2020.615287.
- Integral characterization of normal and alopecic hair at different degeneration stages by in-situ visible and chemical imagingHou S, He S, Xie J, Li M, Hong M, Guan F, Hu Y, Huang Y, Xu C. Integral characterization of normal and alopecic hair at different degeneration stages by in-situ visible and chemical imaging. Spectrochimica Acta Part A Molecular And Biomolecular Spectroscopy 2020, 235: 118315. PMID: 32289732, DOI: 10.1016/j.saa.2020.118315.
- Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltrationLam W, Yang X, Jiang Z, han X, Guan F, Hu R, Xu C, Cai W, Cheng W, Liu S, Cai Y, Rattray N, Johnson C, Chen L, Cheng Y. Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration. 2019, 2252-2252. DOI: 10.1158/1538-7445.sabcs18-2252.
- Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltrationLam W, Yang X, Jiang Z, han X, Guan F, Hu R, Xu C, Cai W, Cheng W, Liu S, Cai Y, Rattray N, Johnson C, Chen L, Cheng Y. Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration. Cancer Research 2019, 79: 2252-2252. DOI: 10.1158/1538-7445.am2019-2252.
- Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906)Lam W, Ren Y, Guan F, Jiang Z, Cheng W, Xu CH, Liu SH, Cheng YC. Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906). Frontiers In Pharmacology 2018, 09: 1324. PMID: 30510512, PMCID: PMC6252377, DOI: 10.3389/fphar.2018.01324.
- Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles.Tan Y, Lu C, Jiang M, Zhao N, Li L, Shen S, Guan F, He B, Xiao C, L A, Cheng S, Zu X, Zhang W, Liu X. Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles. Journal Of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored By All-China Association Of Traditional Chinese Medicine, Academy Of Traditional Chinese Medicine 2018, 38: 773-780. PMID: 32185996.
- Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70Wang Y, Lam W, Chen SR, Guan FL, Dutchman GE, Francis S, Baker DC, Cheng YC. Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70. Scientific Reports 2016, 6: 32832. PMID: 27596272, PMCID: PMC5011780, DOI: 10.1038/srep32832.
- Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion SubstratesTsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán J, Hang HC. Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. Journal Of The American Chemical Society 2016, 138: 2209-2218. PMID: 26847396, PMCID: PMC4831573, DOI: 10.1021/jacs.5b11575.
- The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018)Lam W, Jiang Z, Guan F, Hu R, Liu SH, Chu E, Cheng YC. The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). BMC Complementary Medicine And Therapies 2014, 14: 490. PMID: 25510341, PMCID: PMC4302098, DOI: 10.1186/1472-6882-14-490.
- PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different TissuesKong A, Lam, Bussom S, Jiang Z, Zhang W, Guan F, Liu S, Cheng Y. PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues. 2013, 549-562. DOI: 10.1201/b15323-38.
- Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironmentWang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Medical Genomics 2011, 4: 38. PMID: 21569348, PMCID: PMC3117677, DOI: 10.1186/1755-8794-4-38.
- The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal ToxicityLam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine 2010, 2: 45ra59. PMID: 20720216, DOI: 10.1126/scitranslmed.3001270.