Dongying Chen, MD, PhD
Associate Research Scientist (Cardiovascular Medicine)
Research & Publications
Biography
News
Research Summary
1. Developmental vascular morphogenesis. We aim to elucidate the crosstalk of two environmental cues, VEGF and fluid shear stress, in coordinating angiogenesis and arteriogenesis during capillary-to-artery cell fate transition.
2. Adult arteriogenesis and therapeutic neovascularization. This involves the mechanisms of growth factor signaling and hemodynamic force in control of blood flow recovery in arterial occlusive diseases.
3. VEGF receptor signaling in endothelial permeability.
Coauthors
Public Health Interests
Cardiovascular Diseases
Research Image
Arteriogenesis during capillary remodeling
Selected Publications
- Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch DevelopmentWarkala M, Chen D, Ramirez A, Jubran A, Schonning M, Wang X, Zhao H, Astrof S. Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development. Circulation Research 2020, 128: e27-e44. PMID: 33249995, PMCID: PMC7864893, DOI: 10.1161/circresaha.120.318200.
- Emerging roles of PLCγ1 in endothelial biologyChen D, Simons M. Emerging roles of PLCγ1 in endothelial biology. Science Signaling 2021, 14 PMID: 34344833, PMCID: PMC8507396, DOI: 10.1126/scisignal.abc6612.
- Developmental Perspectives on Arterial Fate SpecificationChen D, Schwartz MA, Simons M. Developmental Perspectives on Arterial Fate Specification. Frontiers In Cell And Developmental Biology 2021, 9: 691335. PMID: 34249941, PMCID: PMC8269928, DOI: 10.3389/fcell.2021.691335.
- Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart fieldWang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S. Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Developmental Biology 2016, 421: 108-117. PMID: 27955943, PMCID: PMC5221477, DOI: 10.1016/j.ydbio.2016.12.010.
- Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific mannerChen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Developmental Biology 2015, 407: 195-210. PMID: 26434918, PMCID: PMC5312697, DOI: 10.1016/j.ydbio.2015.09.016.
- Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/SrcSjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love D, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src. Journal Of Clinical Investigation 2023, 133: e161366. PMID: 37651195, PMCID: PMC10575733, DOI: 10.1172/jci161366.
- Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid AbsorptionZarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim Y, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Circulation Research 2023, 133: 333-349. PMID: 37462027, PMCID: PMC10530007, DOI: 10.1161/circresaha.123.322607.
- FRS2α-dependent cell fate transition during endocardial cushion morphogenesisChen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental Biology 2019, 458: 88-97. PMID: 31669335, DOI: 10.1016/j.ydbio.2019.10.022.
- Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularizationCorti F, Wang Y, Rhodes JM, Atri D, Archer-Hartmann S, Zhang J, Zhuang ZW, Chen D, Wang T, Wang Z, Azadi P, Simons M. Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nature Communications 2019, 10: 2124. PMID: 31064993, PMCID: PMC6504881, DOI: 10.1038/s41467-019-10205-0.
- N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularizationCorti F, Wang Y, Rhodes JM, Atri D, Archer-Hartmann S, Zhang J, Zhuang ZW, Chen D, Wang T, Wang Z, Azadi P, Simons M. N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nature Communications 2019, 10: 1562. PMID: 30952866, PMCID: PMC6450910, DOI: 10.1038/s41467-019-09605-z.
- Reprogramming the EndocardiumChen D, Simons M. Reprogramming the Endocardium. Circulation Research 2018, 122: 913-915. PMID: 29599272, PMCID: PMC5880288, DOI: 10.1161/circresaha.118.312810.
- Primary carcinosarcoma of the liver: clinicopathologic features of 5 cases and a review of the literature.Lao XM, Chen DY, Zhang YQ, Xiang J, Guo RP, Lin XJ, Li JQ. Primary carcinosarcoma of the liver: clinicopathologic features of 5 cases and a review of the literature. The American Journal Of Surgical Pathology 2007, 31: 817-26. PMID: 17527068, DOI: 10.1097/01.pas.0000213431.07116.e0.