Charles Lockwood, MD
Research & Publications
Biography
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Research Summary
Trophoblast, Placenta, Labor Premature, Fetal Diseases, Pregnancy Complications, Pregnancy, Endometrium, Fibronectins, Plasminogen Activators, Plasminogen Inactivators, Annexins, Proteins, Fetal Membranes, EmbryoMy research is devoted to understanding the basic mechanisms underlying the maintenance of normal hemostasis during blastocyst invasion and the establishment of the uteroplacental circulation as well as those mechanisms involved int he pathologic outcomes associated with these processes.
We are also investigating the pathophysiology of abnormal uterine bleeding (AUB) associated with the perimenarchal and perimenopausal periods, anovulation, myomas, polyps, carcinomas and long-term progestin-only contraceptive therapy. A future goal involves the early identification of individuals predisposed to these pathologies in order to prevent preterm labor, abruptions and abnormal uterine bleeding by therapies that block the pathways leading to these events.
Extensive Research Description
His lab has also focused on the pathophysiology of abnormal uterine bleeding (AUB) associated with the idiopathic menorrhagia, anovulation, myomas, endometrial polyps and long-term progestin-only contraceptive therapy. Of key interest to these studies is the identification of pathways which may lead to aberrant angiogenesis. Recently he has examined aberrant tissue factor expression in endometriotic endothelium as a target for therapy using the immunoconjugate molecule, ICON. He has over 220 peer reviewed publications, 39 chapters in distinguished text books, is editor of four text books, UpToDate - Obstetrics and Contemporary Ob/Gyn, the nation’s must widely read Ob/Gyn journal. He serves on the editorial board of several journals and is a former President of the the Society for Gynecologic Investigation
- Citations: 5983
- Citations/year: 426
- Average citations/paper: 22.7
- H-index: 40
Targeting tissue factor expression in endometriosis and endometrial cancer with an immunoconjugate molecule.
Uncovering the causes of abnormal uterine bleeding in patients receiving long-term progestin-only contraceptives.
Dissecting the mechanisms for progesterone receptor withdrawal in infection and abruption-associated preterm deliveries.
Uncovering the control of leukocyte traffiking in the placental bed and the role of decidual macrophages in impairning endovascular extravillous trophoblast invasion.
Coauthors
Selected Publications
- Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblastsde Assis V, Kayisli U, Ozmen A, Semerci N, Totary-Jain H, Pakasticali N, Halade G, Lockwood C, Guzeloglu-Kayisli O. Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts. American Journal Of Pathology 2024 PMID: 38879084, DOI: 10.1016/j.ajpath.2024.05.005.
- Career Reflections: Delivering Excellence by Building Great TeamsLockwood C. Career Reflections: Delivering Excellence by Building Great Teams. Clinical Obstetrics & Gynecology 2023, 67: 321-325. PMID: 38149681, DOI: 10.1097/grf.0000000000000849.
- Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia PathogenesisOzmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.
- Pathogenesis and Prediction of Preterm DeliveryKendle A, Buhimschi C, Lockwood C. Pathogenesis and Prediction of Preterm Delivery. 2023, 344-360. DOI: 10.1002/9781119636540.ch40.
- Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivityPavlovic Z, Hsin-Yu Pai A, Hsiao T, Yen C, Alhasan H, Ozmen A, New E, Guo X, Imudia A, Guzeloglu-Kayisli O, Lockwood C, Kayisli U. Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity. F&S Science 2023, 5: 92-103. PMID: 37972693, DOI: 10.1016/j.xfss.2023.11.003.
- Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual CellsLockwood CJ, Murk W, Kayisli UA, Buchwalder LF, Huang S, Funai EF, Krikun G, Schatz F. Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 2164-2170. PMID: 19276228, PMCID: PMC2690421, DOI: 10.1210/jc.2009-0065.
- Impact of a comprehensive patient safety strategy on obstetric adverse eventsPettker CM, Thung SF, Norwitz ER, Buhimschi CS, Raab CA, Copel JA, Kuczynski E, Lockwood CJ, Funai EF. Impact of a comprehensive patient safety strategy on obstetric adverse events. American Journal Of Obstetrics And Gynecology 2009, 200: 492.e1-492.e8. PMID: 19249729, DOI: 10.1016/j.ajog.2009.01.022.
- Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsiaGuller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.
- Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual CellsLockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells. American Journal Of Pathology 2008, 172: 1571-1579. PMID: 18467705, PMCID: PMC2408417, DOI: 10.2353/ajpath.2008.070629.
- Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related AngiogenesisLockwood CJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis. Annals Of The New York Academy Of Sciences 2008, 1127: 67-72. PMID: 18443332, DOI: 10.1196/annals.1434.013.
- Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang SJ, Buchwalder LF, Murk W, Funai EF, Schatz F. Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1. Biology Of Reproduction 2008, 78: 1064-1072. PMID: 18276934, PMCID: PMC3045968, DOI: 10.1095/biolreprod.107.063743.
- Intrauterine transfusion for rhesus alloimmunization elevates fetal β2-microglobulin levelsRadunovic N, Kuczynski E, Funai E, Nastic D, Di Renzo G, Lockwood C. Intrauterine transfusion for rhesus alloimmunization elevates fetal β2-microglobulin levels. The Journal Of Maternal-Fetal & Neonatal Medicine 2003, 13: 246-249. PMID: 12854925, DOI: 10.1080/jmf.13.4.246.249.
- Progestin-Epidermal Growth Factor Regulation of Tissue Factor Expression during Decidualization of Human Endometrial Stromal CellsLockwood C. Progestin-Epidermal Growth Factor Regulation of Tissue Factor Expression during Decidualization of Human Endometrial Stromal Cells. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 297-301. DOI: 10.1210/jc.85.1.297.
- Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220.Lockwood C, Krikun G, Hausknecht V, Papp C, Schatz F. Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220. Endocrinology 1998, 139: 4607-4613. DOI: 10.1210/en.139.11.4607.
- The effect of fetal intravascular blood transfusion on plasma endothelin levels in fetuses with rhesus alloimmunization.Radunovic N, Nastic D, Rebarber A, Kuczynski E, Lockwood C. The effect of fetal intravascular blood transfusion on plasma endothelin levels in fetuses with rhesus alloimmunization. Obstetrics And Gynecology 1998, 91: 956-60. PMID: 9611003, DOI: 10.1016/s0029-7844(98)00073-8.
- Apoptosis and Fas Expression in Human Fetal Membranes1Runić R, Lockwood C, LaChapelle L, Dipasquale B, Demopoulos R, Kumar A, Guller S. Apoptosis and Fas Expression in Human Fetal Membranes1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 660-666. PMID: 9467589, DOI: 10.1210/jcem.83.2.4600.
- Expression of 11 beta-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cellsArcuri F, Monder C, Lockwood C, Schatz F. Expression of 11 beta-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cells. Endocrinology 1996, 137: 595-600. DOI: 10.1210/en.137.2.595.
- Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placentaGuller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.
- Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherenceGuller S, Wozniak R, Krikun G, Burnham J, Kaplan P, Lockwood C. Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology 1993, 133: 1139-1146. DOI: 10.1210/en.133.3.1139.
- Growth hormone and fibronectin expression in 3T3 preadipose cells.Guller S, Allen D, Corin R, Lockwood C, Sonenberg M. Growth hormone and fibronectin expression in 3T3 preadipose cells. Endocrinology 1992, 130: 2609-2616. DOI: 10.1210/en.130.5.2609.