Liubin Yang
MD, PhD, FACOG
Instructor
Research & Publications
Biography
Research Summary
Gene therapy for ovarian insufficiency; Mechanism of primary ovarian insufficiency; Genetic determinants of primary ovarian insufficiency and diminished ovarian reserve; Molecular biology of ovarian aging
Coauthors
Selected Publications
- Comparison of Female Ovarian Reserve Before vs After COVID-19 VaccinationYang L, Neal S, Lee T, Chou A, Schutt A, Gibbons W. Comparison of Female Ovarian Reserve Before vs After COVID-19 Vaccination. JAMA Network Open 2023, 6: e2318804. PMID: 37326996, PMCID: PMC10276301, DOI: 10.1001/jamanetworkopen.2023.18804.
- Small Bowel Obstruction in Postpartum Vaginal Delivery due to Prior Abdominal Adhesions Case ReportYang L, Kao L. Small Bowel Obstruction in Postpartum Vaginal Delivery due to Prior Abdominal Adhesions Case Report. Case Reports In Obstetrics And Gynecology 2023, 2023: 6563205. PMID: 37025389, PMCID: PMC10072967, DOI: 10.1155/2023/6563205.
- Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokineticsYang L, Peavey M, Kaskar K, Chappell N, Zhu L, Devlin D, Valdes C, Schutt A, Woodard T, Zarutskie P, Cochran R, Gibbons W. Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics. F&S Reports 2022, 3: 116-123. PMID: 35789724, PMCID: PMC9250114, DOI: 10.1016/j.xfre.2022.04.004.
- Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian developmentBarsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson C. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. The Journal Of Steroid Biochemistry And Molecular Biology 2021, 207: 105830. PMID: 33515680, PMCID: PMC8056856, DOI: 10.1016/j.jsbmb.2021.105830.
- Poor blastocyst formation from good quality day three embryos is associated with asthenospermiaYadav G, Yang L, Kaskar K, Cochran R, Selvanesan B, Gibbons W. Poor blastocyst formation from good quality day three embryos is associated with asthenospermia. Reproductive BioMedicine Online 2020, 41: e5-e6. DOI: 10.1016/j.rbmo.2020.08.026.
- Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controlsChappell N, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W, Blesson C. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F&S Reports 2020, 1: 125-132. PMID: 34223228, PMCID: PMC8244380, DOI: 10.1016/j.xfre.2020.05.006.
- DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated LeukemiasYang L, Rodriguez B, Mayle A, Park H, Lin X, Luo M, Jeong M, Curry C, Kim S, Ruau D, Zhang X, Zhou T, Zhou M, Rebel V, Challen G, Göttgens B, Lee J, Rau R, Li W, Goodell M. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 2016, 30: 363-365. PMID: 27505680, DOI: 10.1016/j.ccell.2016.07.015.
- DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated LeukemiasYang L, Rodriguez B, Mayle A, Park H, Lin X, Luo M, Jeong M, Curry C, Kim S, Ruau D, Zhang X, Zhou T, Zhou M, Rebel V, Challen G, Göttgens B, Lee J, Rau R, Li W, Goodell M. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 2016, 29: 922-934. PMID: 27300438, PMCID: PMC4908977, DOI: 10.1016/j.ccell.2016.05.003.
- Long Non-Coding RNAs Control Hematopoietic Stem Cell FunctionLuo M, Jeong M, Sun D, Park H, Rodriguez B, Xia Z, Yang L, Zhang X, Sheng K, Darlington G, Li W, Goodell M. Long Non-Coding RNAs Control Hematopoietic Stem Cell Function. Cell Stem Cell 2015, 16: 426-438. PMID: 25772072, PMCID: PMC4388783, DOI: 10.1016/j.stem.2015.02.002.
- DNMT3A in haematological malignanciesYang L, Rau R, Goodell M. DNMT3A in haematological malignancies. Nature Reviews Cancer 2015, 15: 152-165. PMID: 25693834, PMCID: PMC5814392, DOI: 10.1038/nrc3895.
- Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformationMayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry C, Challen G, Li W, Wheeler D, Rebel V, Goodell M. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood 2015, 125: 629-638. PMID: 25416277, PMCID: PMC4304108, DOI: 10.1182/blood-2014-08-594648.
- Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem CellsChallen G, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington G, Li W, Goodell M. Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells. Cell Stem Cell 2014, 15: 350-364. PMID: 25130491, PMCID: PMC4163922, DOI: 10.1016/j.stem.2014.06.018.
- Large conserved domains of low DNA methylation maintained by Dnmt3aJeong M, Sun D, Luo M, Huang Y, Challen G, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim S, Yang L, Ko M, Chen R, Göttgens B, Lee J, Gunaratne P, Godley L, Darlington G, Rao A, Li W, Goodell M. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature Genetics 2013, 46: 17-23. PMID: 24270360, PMCID: PMC3920905, DOI: 10.1038/ng.2836.
- Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout MiceRossi L, Lin K, Boles N, Yang L, King K, Jeong M, Mayle A, Goodell M. Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice. Cell Stem Cell 2012, 11: 302-317. PMID: 22958929, PMCID: PMC3461270, DOI: 10.1016/j.stem.2012.08.006.
- Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsiaGuller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.
- Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous FibroblastsLee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.