Charles Bruce, PhD
Associate Professor of Neuroscience
Research & Publications
Biography
Research Summary
My laboratory's research concerns cortical mechanisms of behavior and our experiments involve studying the activity of single neurons in different regions of the neocortex. These neuronal recording data are complemented by several related techniques including intracortical microstimulation, physiological identification of corticocortical pathways with antidromic activation, neurochemical injection,neuroanatomical tracer injection, etc., and also by investigations of the behavioral effects of experimental brain lesions and computer simulations of cortical networks' underlying behavior. "Our mission is nothing short of trying to crack the brain code."
Specialized Terms: Neurophysiology of Sensorimotor Processing in Cerebral Cortex
Research Interests
Cerebral Cortex; Neurobiology; Neurophysiology; Sensorimotor Cortex
Selected Publications
- Neural circuitry of judgment and decision mechanismsOpris I, Bruce CJ. Neural circuitry of judgment and decision mechanisms Brain Research Reviews 2005, 48: 509-526. PMID: 15914255, DOI: 10.1016/j.brainresrev.2004.11.001.
- Eye MovementsBruce C, Friedman H. Eye Movements 2002, 269-297. DOI: 10.1016/b0-12-227210-2/00142-4.
- Supplementary Eye Field: Representation of Saccades and Relationship Between Neural Response Fields and Elicited Eye MovementsRusso G, Bruce C. Supplementary Eye Field: Representation of Saccades and Relationship Between Neural Response Fields and Elicited Eye Movements Journal Of Neurophysiology 2000, 84: 2605-2621. PMID: 11068002, DOI: 10.1152/jn.2000.84.5.2605.
- Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye FieldShi D, Friedman H, Bruce C. Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye Field Journal Of Neurophysiology 1998, 80: 458-464. PMID: 9658064, DOI: 10.1152/jn.1998.80.1.458.
- Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye FieldBurman D, Bruce C. Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field Journal Of Neurophysiology 1997, 77: 2252-2267. PMID: 9163356, DOI: 10.1152/jn.1997.77.5.2252.
- Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate systemRusso GS, Bruce CJ. Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system Journal Of Neurophysiology 1996, 76: 825-848. PMID: 8871203, DOI: 10.1152/jn.1996.76.2.825.
- Topography of projections to posterior cortical areas from the macaque frontal eye fieldsStanton G, Bruce C, Goldberg M. Topography of projections to posterior cortical areas from the macaque frontal eye fields The Journal Of Comparative Neurology 1995, 353: 291-305. PMID: 7745137, DOI: 10.1002/cne.903530210.
- Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesionsMacavoy M, Bruce C. Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions International Journal Of Neuroscience 1995, 80: 117-151. PMID: 7775044, DOI: 10.3109/00207459508986097.
- Physiological correlate of fixation disengagement in the primate's frontal eye fieldDias E, Bruce C. Physiological correlate of fixation disengagement in the primate's frontal eye field Journal Of Neurophysiology 1994, 72: 2532-2537. PMID: 7884478, DOI: 10.1152/jn.1994.72.5.2532.
- Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye fieldGottlieb J, MacAvoy M, Bruce C. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field Journal Of Neurophysiology 1994, 72: 1634-1653. PMID: 7823092, DOI: 10.1152/jn.1994.72.4.1634.
- Frontal eye field activity preceding aurally guided saccadesRusso G, Bruce C. Frontal eye field activity preceding aurally guided saccades Journal Of Neurophysiology 1994, 71: 1250-1253. PMID: 8201415, DOI: 10.1152/jn.1994.71.3.1250.
- Topography of projections to the frontal lobe from the macaque frontal eye fieldsStanton G, Bruce C, Goldberg M. Topography of projections to the frontal lobe from the macaque frontal eye fields The Journal Of Comparative Neurology 1993, 330: 286-301. PMID: 8491870, DOI: 10.1002/cne.903300209.
- Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas"Funahashi S, Bruce C, Goldman-Rakic P. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas" Journal Of Neuroscience 1993, 13: 1479-1497. PMID: 8463830, PMCID: PMC6576716, DOI: 10.1523/jneurosci.13-04-01479.1993.
- Smooth eye movements elicited by microstimulation in the primate frontal eye fieldGottlieb J, Bruce C, MacAvoy M. Smooth eye movements elicited by microstimulation in the primate frontal eye field Journal Of Neurophysiology 1993, 69: 786-799. PMID: 8385195, DOI: 10.1152/jn.1993.69.3.786.
- Effect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fieldsRusso G, Bruce C. Effect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields Journal Of Neurophysiology 1993, 69: 800-818. PMID: 8385196, DOI: 10.1152/jn.1993.69.3.800.
- Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortexFunahashi S, Bruce C, Goldman-Rakic P. Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex Journal Of Neurophysiology 1991, 65: 1464-1483. PMID: 1875255, DOI: 10.1152/jn.1991.65.6.1464.
- Smooth-pursuit eye movement representation in the primate frontal eye field.MacAvoy M, Gottlieb J, Bruce C. Smooth-pursuit eye movement representation in the primate frontal eye field. Cerebral Cortex 1991, 1: 95-102. PMID: 1822728, DOI: 10.1093/cercor/1.1.95.
- Response field biases in parietal, temporal, and frontal lobe visual areasBruce C, MacAvoy M. Response field biases in parietal, temporal, and frontal lobe visual areas Behavioral And Brain Sciences 1990, 13: 546-547. DOI: 10.1017/s0140525x00080067.
- Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signalGoldberg M, Bruce C. Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal Journal Of Neurophysiology 1990, 64: 489-508. PMID: 2213128, DOI: 10.1152/jn.1990.64.2.489.
- Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigmsFunahashi S, Bruce C, Goldman-Rakic P. Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms Journal Of Neurophysiology 1990, 63: 814-831. PMID: 2341879, DOI: 10.1152/jn.1990.63.4.814.
- [22] Double-Label [3H]2-Deoxyglucose and [14C]2-Deoxyglucose Method for Mapping Brain Activity Underlying Two Experimental Conditions in the Same AnimalFriedman H, Bruce C, Goldman-Rakic P. [22] Double-Label [3H]2-Deoxyglucose and [14C]2-Deoxyglucose Method for Mapping Brain Activity Underlying Two Experimental Conditions in the Same Animal 1990, 3: 389-412. DOI: 10.1016/b978-0-12-185255-9.50027-4.
- Contributors to Volume 3Alheid G, Black J, Brown T, Bruce C, Calverley R, Casagrande V, Cunningham E, Duncan G, Friedman H, Gehlert D, Gerfen C, Goldman-Rakic P, Hochberg R, Hoyland J, Hutchins J, Jones D, Jones E, Jones S, Kroese A, Lachica E, Leranth C, MacLusky N, Mason W, Mayhew T, Mizukawa K, Mortrud M, Ogawa Y, Pfaff D, Pfeiffer S, Rawlings S, Relf G, Rhodes K, Rosene D, Sawchenko P, Schmued L, Schwanzel-Fukuda M, Smolen A, Sripairojthikoon W, Stumpf W, van Netten S, Wyss J, Yamamoto T, Yamamura H. Contributors to Volume 3 1990, 3: ix-xi. DOI: 10.1016/b978-0-12-185255-9.50003-1.
- Neocortical memory circuits.Goldman-Rakic P, Funahashi S, Bruce C. Neocortical memory circuits. Cold Spring Harbor Symposia On Quantitative Biology 1990, 55: 1025-38. PMID: 2132811, DOI: 10.1101/sqb.1990.055.01.097.
- Resolution of metabolic columns by a double-label 2-DG technique: interdigitation and coincidence in visual cortical areas of the same monkeyFriedman H, Bruce C, Goldman-Rakic P. Resolution of metabolic columns by a double-label 2-DG technique: interdigitation and coincidence in visual cortical areas of the same monkey Journal Of Neuroscience 1989, 9: 4111-4121. PMID: 2687438, PMCID: PMC6569629, DOI: 10.1523/jneurosci.09-12-04111.1989.
- Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortexFunahashi S, Bruce C, Goldman-Rakic P. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex Journal Of Neurophysiology 1989, 61: 331-349. PMID: 2918358, DOI: 10.1152/jn.1989.61.2.331.
- Frontal eye field efferents in the macaque monkey: I. Subcortical pathways and topography of striatal and thalamic terminal fieldsStanton G, Goldberg M, Bruce C. Frontal eye field efferents in the macaque monkey: I. Subcortical pathways and topography of striatal and thalamic terminal fields The Journal Of Comparative Neurology 1988, 271: 473-492. PMID: 2454970, DOI: 10.1002/cne.902710402.
- Frontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and ponsStanton G, Goldberg M, Bruce C. Frontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and pons The Journal Of Comparative Neurology 1988, 271: 493-506. PMID: 2454971, DOI: 10.1002/cne.902710403.
- The role of striate cortex in the guidance of eye movements in the monkeySegraves M, Goldberg M, Deng S, Bruce C, Ungerleider L, Mishkin M. The role of striate cortex in the guidance of eye movements in the monkey Journal Of Neuroscience 1987, 7: 3040-3058. PMID: 3668615, PMCID: PMC6569180, DOI: 10.1523/jneurosci.07-10-03040.1987.
- A sequential double-label 14C- and 3H-2-DG technique: validation by double-dissociation of functional statesFriedman H, Bruce C, Goldman-Rakic P. A sequential double-label 14C- and 3H-2-DG technique: validation by double-dissociation of functional states Experimental Brain Research 1987, 66: 543-554. PMID: 3609200, DOI: 10.1007/bf00270687.
- Both striate cortex and superior colliculus contribute to visual properties of neurons in superior temporal polysensory area of macaque monkeyBruce C, Desimone R, Gross C. Both striate cortex and superior colliculus contribute to visual properties of neurons in superior temporal polysensory area of macaque monkey Journal Of Neurophysiology 1986, 55: 1057-1075. PMID: 3711967, DOI: 10.1152/jn.1986.55.5.1057.
- The effect of attentive fixation on eye movements evoked by electrical stimulation of the frontal eye fieldsGoldberg M, Bushnell M, Bruce C. The effect of attentive fixation on eye movements evoked by electrical stimulation of the frontal eye fields Experimental Brain Research 1986, 61: 579-584. PMID: 3956616, DOI: 10.1007/bf00237584.
- The role of the arcuate frontal eye fields in the generation of saccadic eye movementsGoldberg M, Bruce C. The role of the arcuate frontal eye fields in the generation of saccadic eye movements 1986, 64: 143-154. PMID: 3726143, DOI: 10.1016/s0079-6123(08)63409-3.
- Somatosensory cortex in macaque monkeys: laminar differences in receptive field size in areas 3b and 1Sur M, Garraghty P, Bruce C. Somatosensory cortex in macaque monkeys: laminar differences in receptive field size in areas 3b and 1 Brain Research 1985, 342: 391-395. PMID: 4041845, DOI: 10.1016/0006-8993(85)91144-8.
- Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movementsBruce C, Goldberg M, Bushnell M, Stanton G. Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements Journal Of Neurophysiology 1985, 54: 714-734. PMID: 4045546, DOI: 10.1152/jn.1985.54.3.714.
- Cerebral cortical activity associated with the orientation of visual attention in the rhesus monkeyGoldberg M, Bruce C. Cerebral cortical activity associated with the orientation of visual attention in the rhesus monkey Vision Research 1985, 25: 471-481. PMID: 4024466, DOI: 10.1016/0042-6989(85)90072-0.
- Physiology of the frontal eye fieldsBruce C, Goldberg M. Physiology of the frontal eye fields Trends In Neurosciences 1984, 7: 436-441. DOI: 10.1016/s0166-2236(84)80149-6.
- Stimulus-selective properties of inferior temporal neurons in the macaqueDesimone R, Albright T, Gross C, Bruce C. Stimulus-selective properties of inferior temporal neurons in the macaque Journal Of Neuroscience 1984, 4: 2051-2062. PMID: 6470767, PMCID: PMC6564959, DOI: 10.1523/jneurosci.04-08-02051.1984.
- Face recognition by monkeys: Absence of an inversion effectBruce C. Face recognition by monkeys: Absence of an inversion effect Neuropsychologia 1982, 20: 515-521. PMID: 7145077, DOI: 10.1016/0028-3932(82)90025-2.
- Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque.Bruce C, Desimone R, Gross C. Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque. Journal Of Neurophysiology 1981, 46: 369-384. PMID: 6267219, DOI: 10.1152/jn.1981.46.2.369.
- Visual experience and development of interocular orientation disparity in visual cortex.Bruce C, Isley M, Shinkman P. Visual experience and development of interocular orientation disparity in visual cortex. Journal Of Neurophysiology 1981, 46: 215-228. PMID: 7264711, DOI: 10.1152/jn.1981.46.2.215.
- Cortical Visual Areas of the Temporal LobeGross C, Bruce C, Desimone R, Fleming J, Gattass R. Cortical Visual Areas of the Temporal Lobe 1981, 187-216. DOI: 10.1007/978-1-4612-5814-8_8.
- Analysis of the effects of operant conditioning on cortical unit response patternsShinkman P, Bruce C. Analysis of the effects of operant conditioning on cortical unit response patterns Physiology & Behavior 1979, 23: 377-383. PMID: 504425, DOI: 10.1016/0031-9384(79)90381-0.
- Binocular Differences in Cortical Receptive Fields of Kittens After Rotationally Disparate Binocular ExperienceShinkman P, Bruce C. Binocular Differences in Cortical Receptive Fields of Kittens After Rotationally Disparate Binocular Experience Science 1977, 197: 285-287. PMID: 877554, DOI: 10.1126/science.877554.
- Quantitative analysis of unit response patterns in cat visual cortexPfingst B, Bruce C, Shinkman P. Quantitative analysis of unit response patterns in cat visual cortex Experimental Neurology 1975, 46: 215-228. PMID: 1109339, DOI: 10.1016/0014-4886(75)90044-8.
- Operant Conditioning of Single-Unit Response Patterns in Visual CortexShinkman P, Bruce C, Pfingst B. Operant Conditioning of Single-Unit Response Patterns in Visual Cortex Science 1974, 184: 1194-1196. PMID: 4598035, DOI: 10.1126/science.184.4142.1194.