Carolina Gomis Perez, PhD
Associate Research Scientist
Research & Publications
Biography
News
Coauthors
Selected Publications
- Cell membrane tension gradients, membrane flows and cellular processesYan Q, Perez C, Karatekin E. Cell membrane tension gradients, membrane flows and cellular processes. Physiology 2024 PMID: 38501962, DOI: 10.1152/physiol.00007.2024.
- Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodyniaNascimento de Lima A, Zhang H, Chen L, Effraim P, Gomis-Perez C, Cheng X, Huang J, Waxman S, Dib-Hajj S. Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain 2024, awae071. PMID: 38447953, DOI: 10.1093/brain/awae071.
- Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocationLandajuela A, Braun M, Martínez-Calvo A, Rodrigues CDA, Gomis Perez C, Doan T, Rudner DZ, Wingreen NS, Karatekin E. Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation. Current Biology 2022, 32: 4186-4200.e8. PMID: 36041438, PMCID: PMC9730832, DOI: 10.1016/j.cub.2022.08.014.
- Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminalsGomis Perez C, Dudzinski NR, Rouches M, Landajuela A, Machta B, Zenisek D, Karatekin E. Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals. Science Advances 2022, 8: eabl4411. PMID: 34985955, DOI: 10.1126/sciadv.abl4411.
- An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channelUrrutia J, Aguado A, Gomis-Perez C, Muguruza-Montero A, Ballesteros OR, Zhang J, Nuñez E, Malo C, Chung HJ, Leonardo A, Bergara A, Villarroel A. An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel. BMC Biology 2021, 19: 109. PMID: 34020651, PMCID: PMC8138981, DOI: 10.1186/s12915-021-01040-1.
- A 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membraneSizova D, Huang J, Akin E, Estacion M, Gomis-Perez C, Waxman S, Dib-Hajj S. A 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane. Journal Of Biological Chemistry 2020, 295: 1077-1090. DOI: 10.1016/s0021-9258(17)49917-0.
- Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathyGomis‐Pérez C, Urrutia J, Marcé‐Grau A, Malo C, López‐Laso E, Felipe‐Rucián A, Raspall‐Chaure M, Macaya A, Villarroel A. Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy. Epilepsia 2018, 60: 139-148. PMID: 30478917, DOI: 10.1111/epi.14609.
- Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic ClampMis MA, Yang Y, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG. Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp. Journal Of Neuroscience 2018, 39: 382-392. PMID: 30459225, PMCID: PMC6335750, DOI: 10.1523/jneurosci.2433-18.2018.
- Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channelBernardo-Seisdedos G, Nuñez E, Gomis-Perez C, Malo C, Villarroel Á, Millet O. Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channel. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 2395-2400. PMID: 29463698, PMCID: PMC5873240, DOI: 10.1073/pnas.1800235115.
- Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutantsAlaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A. Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants. Channels 2018, 12: 299-310. PMID: 30126342, PMCID: PMC6161613, DOI: 10.1080/19336950.2018.1511512.
- Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channelsAlaimo A, Nuñez E, Aivar P, Fernández-Orth J, Gomis-Perez C, Bernardo-Seisdedos G, Malo C, Villarroel A. Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels. Scientific Reports 2017, 7: 13425. PMID: 29044210, PMCID: PMC5647379, DOI: 10.1038/s41598-017-13811-4.
- Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by CalmodulinGomis-Perez C, Soldovieri MV, Malo C, Ambrosino P, Taglialatela M, Areso P, Villarroel A. Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin. Frontiers In Molecular Neuroscience 2017, 10: 117. PMID: 28507506, PMCID: PMC5410570, DOI: 10.3389/fnmol.2017.00117.
- Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3)*Anta B, Martín-Rodríguez C, Gomis-Perez C, Calvo L, López-Benito S, Calderón-García AA, Vicente-García C, Villarroel Á, Arévalo JC. Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3)*. Journal Of Biological Chemistry 2016, 291: 19132-19145. PMID: 27445338, PMCID: PMC5009282, DOI: 10.1074/jbc.m116.722637.
- Structural Insights of the Calcium Mediated Reorganization of the Calmodulin/Kv7.2 Channel ComplexVillarroel A, Bernardo-Seisdedos G, Alaimo A, Gomis-Perez C, Alberdi A, Malo C, Areso P, Millet O. Structural Insights of the Calcium Mediated Reorganization of the Calmodulin/Kv7.2 Channel Complex. Biophysical Journal 2016, 110: 102a. DOI: 10.1016/j.bpj.2015.11.608.
- TRPA1 Is Expressed in Central But Not in Peripheral GliaVellani, V. , Gomis-Perez C. , Pinti, M. , Prandini, M. , Pavesi, G. , Giacomoni, C. and Caprini, M. (2016) TRPA1 Is Expressed in Central But Not in Peripheral Glia. Journal of Biomedical Science and Engineering, 9, 515-531. doi: 10.4236/jbise.2016.911046.
- Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulinAmbrosino P, Alaimo A, Bartollino S, Manocchio L, De Maria M, Mosca I, Gomis-Perez C, Alberdi A, Scambia G, Lesca G, Villarroel A, Taglialatela M, Soldovieri MV. Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin. Biochimica Et Biophysica Acta 2015, 1852: 1856-1866. PMID: 26073431, DOI: 10.1016/j.bbadis.2015.06.012.
- Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutationAlberdi A, Gomis-Perez C, Bernardo-Seisdedos G, Alaimo A, Malo C, Aldaregia J, Lopez-Robles C, Areso P, Butz E, Wahl-Schott C, Villarroel A. Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation. Journal Of Cell Science 2015, 128: 4014-4023. PMID: 26359296, DOI: 10.1242/jcs.176420.
- An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channelsGomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A. An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels. Journal Of Cell Science 2015, 128: 3155-3163. PMID: 26148514, DOI: 10.1242/jcs.174128.
- Disruption of Assembly/Calmodulin-Binding Coupling and Calmodulin-Dependent Potentiation of Kv7.2 Channels by a Epileptogenic Helix D MutationAlberdi A, Bernardo-Seisdedos G, Gomis-Perez C, Alaimo A, Malo C, Butz E, Wahl-Schott C, Areso P, Villarroel A. Disruption of Assembly/Calmodulin-Binding Coupling and Calmodulin-Dependent Potentiation of Kv7.2 Channels by a Epileptogenic Helix D Mutation. Biophysical Journal 2015, 108: 349a. DOI: 10.1016/j.bpj.2014.11.1912.
- PIP2 and Surface Expression Underlie Apo-Calmodulin Dependent Kv7.2/KCNQ2 Current PotentiationGomis-Perez C, Soldovieri M, Alberdi A, Ambrosino P, Di Maria M, Alaimo A, Bernardo-Seisdedos G, Malo C, Areso P, Taglialatela M, Villarroel A. PIP2 and Surface Expression Underlie Apo-Calmodulin Dependent Kv7.2/KCNQ2 Current Potentiation. Biophysical Journal 2015, 108: 349a. DOI: 10.1016/j.bpj.2014.11.1910.
- Calmodulin Binding to a Novel Site in the AB Module of Kv7.2 Subunits Regulates Surface ExpressionBernardo-Seisdedos G, Fernandez-Orth J, Gomis-Perez C, Alaimo A, Alberdi A, Malo C, Areso P, Villarroel A. Calmodulin Binding to a Novel Site in the AB Module of Kv7.2 Subunits Regulates Surface Expression. Biophysical Journal 2015, 108: 24a. DOI: 10.1016/j.bpj.2014.11.153.
- The Ever Changing Moods of Calmodulin: How Structural Plasticity Entails Transductional AdaptabilityVillarroel A, Taglialatela M, Bernardo-Seisdedos G, Alaimo A, Agirre J, Alberdi A, Gomis-Perez C, Soldovieri MV, Ambrosino P, Malo C, Areso P. The Ever Changing Moods of Calmodulin: How Structural Plasticity Entails Transductional Adaptability. Journal Of Molecular Biology 2014, 426: 2717-2735. PMID: 24857860, DOI: 10.1016/j.jmb.2014.05.016.
- Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin ComplexAlaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Bernardo-Seisdedos G, Malo C, Millet O, Areso P, Villarroel A. Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex. PLOS ONE 2014, 9: e86711. PMID: 24489773, PMCID: PMC3904923, DOI: 10.1371/journal.pone.0086711.
- Calcium-Independent Potentation of Kv7.2 Current Density by CalmodulinGomis-Perez C, Soldovieri V, Alberdi A, Ambrosino P, Alaimo A, Bernardo-Seisdedos G, Areso P, Taglialatela M, Villarroel A. Calcium-Independent Potentation of Kv7.2 Current Density by Calmodulin. Biophysical Journal 2014, 106: 141a-142a. DOI: 10.1016/j.bpj.2013.11.822.
- Pivoting between Calmodulin Lobes in the Calmodulin/Kv7.2 Complex Triggered by CalciumVillarroel A, Alaimo A, Alberdi A, Gomis-Perez C, Fernandez-Orh J, Bernardo-Seisdedos G, Oscar M, Areso P. Pivoting between Calmodulin Lobes in the Calmodulin/Kv7.2 Complex Triggered by Calcium. Biophysical Journal 2013, 104: 41a. DOI: 10.1016/j.bpj.2012.11.263.
- Cooperativity between calmodulin-binding sites in Kv7.2 channelsAlaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Gómez-Posada JC, Areso P, Villarroel A. Cooperativity between calmodulin-binding sites in Kv7.2 channels. Journal Of Cell Science 2012, 126: 244-253. PMID: 23203804, DOI: 10.1242/jcs.114082.
- Surface Expression and Subunit Specific Control of Steady Protein Levels by the Kv7.2 Helix A-B LinkerAivar P, Fernández-Orth J, Gomis-Perez C, Alberdi A, Alaimo A, Rodríguez MS, Giraldez T, Miranda P, Areso P, Villarroel A. Surface Expression and Subunit Specific Control of Steady Protein Levels by the Kv7.2 Helix A-B Linker. PLOS ONE 2012, 7: e47263. PMID: 23115641, PMCID: PMC3480381, DOI: 10.1371/journal.pone.0047263.
- Biofunctional Silk/Neuron InterfacesBenfenati V, Stahl K, Gomis‐Perez C, Toffanin S, Sagnella A, Torp R, Kaplan D, Ruani G, Omenetto F, Zamboni R, Muccini M. Biofunctional Silk/Neuron Interfaces. Advanced Functional Materials 2012, 22: 1871-1884. DOI: 10.1002/adfm.201102310.
- Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence studyGiannoccaro M, Donadio V, Gomis Pèrez C, Borsini W, Di Stasi V, Liguori R. Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study. Neurological Sciences 2011, 32: 361-363. PMID: 21290160, DOI: 10.1007/s10072-010-0475-2.