Bahman Jabbari, MD
Research & Publications
Biography
News
Research Summary
My current research is focused to improve a number of movement disorders and pain disorders with the use of botulinum toxins (subcutaneous or intramuscular treatment).
Specialized Terms: Parkinson's disease; Movement disorders (dystonia, tremor, chores, tics , tardive dyskinesias); New indications for botulinum toxin treatment in clinical medicine (variety of pain disorders, spasticity and rigidity, etc); Central and peripheral electrophysiology (EEG/EMG); Deep brain stimulation
Extensive Research Description
My scientific interest in botulinum neurotoxin research is based on the wide range of synaptic mechanisms through which these toxins exert their functions. Since botulinum toxins also inhibit the release of acetylcholine from presynaptic vesicles, they can improve hyperkinetic disorders. This is the basis for studying the effect of incobotulinum toxin-A (Xeomin) in Parkinsonian and essential tremor. Previous studies of botulinum toxin A have demonstrated the efficacy of intramuscular onabotulinum toxin A in reducing the tremor of essential tremor, but the results were confounded by development of finger weakness in 30% of these patients. Our current protocols apply a customized pattern of injection (rather than fixed injection) and smaller doses given to more muscles under EMG guidance. This approach will hopefully avoid muscle weakness. In restless legs syndrome, foot movements are dorsiflexion/plantar flexion. Our restless legs syndrome protocol explores the effect of incobotulinum toxin-A by injecting xeomin into gastrocnemius and tibialis anterior muscles. One of our other major areas of interest is in pain research, as both type A and B toxins inhibit the release of pain modulators (substance P, calcitonin gene related peptide, glutamate and bradykinin) from presynaptic vesicles. Two of our current protocols assess the efficacy of incobotulinum toxin-A (Xeomin) in low back pain and abobotulinum toxin-A on post-radiation and post-surgical pain.
We are involved in several protocols involving patients with movement disorders:
1. Evaluation of efficacy of botulinum toxin-A (Xeomin) in Parkinsonian tremor (PI: Jabbari)
This is a double blind, parallel design, randomized study of adult patients with Parkinson’s resting tremor, which involves xeomin injection into forearm and hand muscles under EMG guidance.
2. Evaluation of efficacy of botulinum toxin-A (Xeomin) in treatment of restless legs syndrome (PI: Jabbari)
This is a double blind, randomized, cross over study of adult patients with restless legs syndrome. Xeomin is injected into the tibialis anterior and gastrocnemius muscles.
3. Evaluation of efficacy of botulinum toxin-A (Xeomin) in essential tremor (PI: Machado and co-PI: Jabbari)
This is a double blind, parallel design, randomized study of adult patients with essential tremor in which xeomin is injected into forearm and hand muscles under EMG guidance
4. A phase II, multi-center, open label, study to evaluate the efficacy and safety of WTX101 (a new copper depleter) in adult patients with Wilson’s Disease (PI: Schiltsky and co-PI: Jabbari)
see research description
Coauthors
Research Interests
Botulinum Toxins; Dystonia; Electrophysiology; Movement Disorders; Muscle Spasticity; Neurology; Parkinson Disease; Tremor; Dyskinesias; Deep Brain Stimulation
Selected Publications
- Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover StudyMittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study. Toxins 2018, 10: 401. PMID: 30274305, PMCID: PMC6215171, DOI: 10.3390/toxins10100401.
- Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.
- Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approachMittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach. Parkinsonism & Related Disorders 2018, 56: 65-69. PMID: 29929813, DOI: 10.1016/j.parkreldis.2018.06.019.
- Botulinum Toxin Treatment of Movement DisordersSafarpour Y, Jabbari B. Botulinum Toxin Treatment of Movement Disorders. Current Treatment Options In Neurology 2018, 20: 4. PMID: 29478149, DOI: 10.1007/s11940-018-0488-3.
- Botulinum toxin treatment of pain syndromes –an evidence based reviewSafarpour Y, Jabbari B. Botulinum toxin treatment of pain syndromes –an evidence based review. Toxicon 2018, 147: 120-128. PMID: 29409817, DOI: 10.1016/j.toxicon.2018.01.017.
- Botulinum Toxin Treatment in Multiple Sclerosis—a ReviewSafarpour Y, Mousavi T, Jabbari B. Botulinum Toxin Treatment in Multiple Sclerosis—a Review. Current Treatment Options In Neurology 2017, 19: 33. PMID: 28819801, DOI: 10.1007/s11940-017-0470-5.
- The nature, consequences, and management of neurological disorders in chronic kidney diseaseJabbari B, Vaziri ND. The nature, consequences, and management of neurological disorders in chronic kidney disease. Hemodialysis International 2017, 22: 150-160. PMID: 28799704, DOI: 10.1111/hdi.12587.
- Botulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection ApproachMittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach. Mayo Clinic Proceedings 2017, 92: 1359-1367. PMID: 28789780, DOI: 10.1016/j.mayocp.2017.06.010.
- RimabotulinumtoxinB in sialorrhea: systematic review of clinical trialsDashtipour K, Bhidayasiri R, Chen JJ, Jabbari B, Lew M, Torres-Russotto D. RimabotulinumtoxinB in sialorrhea: systematic review of clinical trials. Journal Of Clinical Movement Disorders 2017, 4: 9. PMID: 28593050, PMCID: PMC5460542, DOI: 10.1186/s40734-017-0055-1.
- Abobotulinum Toxin A in the Treatment of Chronic Low Back PainMachado D, Kumar A, Jabbari B. Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain. Toxins 2016, 8: 374. PMID: 27983689, PMCID: PMC5198568, DOI: 10.3390/toxins8120374.
- History of Botulinum Toxin Treatment in Movement DisordersJabbari B. History of Botulinum Toxin Treatment in Movement Disorders. Tremor And Other Hyperkinetic Movements 2016, 6: 394. PMID: 27917308, PMCID: PMC5133258, DOI: 10.5334/tohm.321.
- Effective Treatment of Paroxysmal Nonkinesigenic Dyskinesia With OxcarbazepineKumar A, Szekely A, Jabbari B. Effective Treatment of Paroxysmal Nonkinesigenic Dyskinesia With Oxcarbazepine. Clinical Neuropharmacology 2016, 39: 201-205. PMID: 27046658, DOI: 10.1097/wnf.0000000000000149.
- Brain metastasis in breast cancer: a comprehensive literature reviewRostami R, Mittal S, Rostami P, Tavassoli F, Jabbari B. Brain metastasis in breast cancer: a comprehensive literature review. Journal Of Neuro-Oncology 2016, 127: 407-414. PMID: 26909695, DOI: 10.1007/s11060-016-2075-3.
- Botulinum Toxin Treatment of Spasticity in Adults and ChildrenMoeini-Naghani I, Hashemi-Zonouz T, Jabbari B. Botulinum Toxin Treatment of Spasticity in Adults and Children. Seminars In Neurology 2016, 36: 064-072. PMID: 26866498, DOI: 10.1055/s-0036-1571847.
- Botulinum Toxin Treatment in NeurologyJabbari B. Botulinum Toxin Treatment in Neurology. Seminars In Neurology 2016, 36: 003-004. PMID: 26866489, DOI: 10.1055/s-0036-1571849.
- Botulinum Toxin Treatment of Neuropathic PainMittal SO, Safarpour D, Jabbari B. Botulinum Toxin Treatment of Neuropathic Pain. Seminars In Neurology 2016, 36: 073-083. PMID: 26866499, DOI: 10.1055/s-0036-1571953.
- Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer PatientsRostami R, Mittal SO, Radmand R, Jabbari B. Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients. Toxins 2016, 8: 22. PMID: 26771640, PMCID: PMC4728544, DOI: 10.3390/toxins8010022.
- Arm Posturing in a Patient Following Stroke: Dystonia, Levitation, Synkinesis, or Spasticity?Irmady K, Jabbari B, Louis ED. Arm Posturing in a Patient Following Stroke: Dystonia, Levitation, Synkinesis, or Spasticity? Tremor And Other Hyperkinetic Movements 2015, 5: 353. PMID: 26682091, PMCID: PMC4681881, DOI: 10.7916/d8222tbh.
- Treatment of Chronic Migraine with Focus on Botulinum NeurotoxinsSchaefer SM, Gottschalk CH, Jabbari B. Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins. Toxins 2015, 7: 2615-2628. PMID: 26184313, PMCID: PMC4516932, DOI: 10.3390/toxins7072615.
- Tremor and Klinefelter’s SyndromeRabin ML, Mittal SO, Jabbari B. Tremor and Klinefelter’s Syndrome. Tremor And Other Hyperkinetic Movements 2015, 5: 304. PMID: 26175955, PMCID: PMC4473154, DOI: 10.7916/d84m93kr.
- Chorea Associated with High Titers of Antiphospholipid Antibodies in the Absence of Antiphospholipid Antibody SyndromeSafarpour D, Buckingham S, Jabbari B. Chorea Associated with High Titers of Antiphospholipid Antibodies in the Absence of Antiphospholipid Antibody Syndrome. Tremor And Other Hyperkinetic Movements 2015, 5: 294. PMID: 25774325, PMCID: PMC4336732, DOI: 10.7916/d8db80m9.
- Brain metastasis from ovarian cancer: a systematic reviewPakneshan S, Safarpour D, Tavassoli F, Jabbari B. Brain metastasis from ovarian cancer: a systematic review. Journal Of Neuro-Oncology 2014, 119: 1-6. PMID: 24789253, DOI: 10.1007/s11060-014-1447-9.
- Bilateral Gluteal Dyskinesia: Discussion of a Rare Movement DisorderSorokin A, Mittal SO, DiCapua D, Jabbari B. Bilateral Gluteal Dyskinesia: Discussion of a Rare Movement Disorder. Tremor And Other Hyperkinetic Movements 2014, 4: 221. PMID: 24678444, PMCID: PMC3958715, DOI: 10.7916/d8bk19dg.
- Primary dystonias and genetic disorders with dystonia as clinical feature of the diseaseMoghimi N, Jabbari B, Szekely AM. Primary dystonias and genetic disorders with dystonia as clinical feature of the disease. European Journal Of Paediatric Neurology 2013, 18: 79-105. PMID: 23911094, DOI: 10.1016/j.ejpn.2013.05.015.
- Intramedullary metastasis in breast cancer – A comprehensive literature reviewRostami R, Safarpour D, Tavassoli FA, Jabbari B. Intramedullary metastasis in breast cancer – A comprehensive literature review. Journal Of The Neurological Sciences 2013, 332: 16-20. PMID: 23778028, DOI: 10.1016/j.jns.2013.05.032.
- Sialorrhea: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum ToxinsLakraj AA, Moghimi N, Jabbari B. Sialorrhea: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins 2013, 5: 1010-1031. PMID: 23698357, PMCID: PMC3709276, DOI: 10.3390/toxins5051010.
- Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum ToxinsLakraj AA, Moghimi N, Jabbari B. Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins 2013, 5: 821-840. PMID: 23612753, PMCID: PMC3705293, DOI: 10.3390/toxins5040821.
- Orofacial Dyskinesia After Moxifloxacin Treatment—A Case With Normal Hepatorenal Function and Review of LiteratureMittal SO, Machado DG, Jabbari B. Orofacial Dyskinesia After Moxifloxacin Treatment—A Case With Normal Hepatorenal Function and Review of Literature. Clinical Neuropharmacology 2012, 35: 292-294. PMID: 23151468, DOI: 10.1097/wnf.0b013e31826ba0eb.
- Ten Years’ Follow-Up of a Family With Myokymia and Muscle Cramps Without AtaxiaMoghimi N, Rosen JB, Jabbari B. Ten Years’ Follow-Up of a Family With Myokymia and Muscle Cramps Without Ataxia. Journal Of Child Neurology 2012, 28: 1493-1495. PMID: 22965560, DOI: 10.1177/0883073812457461.
- OnabotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or RadiationMittal S, Machado DG, Jabbari B. OnabotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or Radiation. Pain Medicine 2012, 13: 1029-1033. PMID: 22776097, DOI: 10.1111/j.1526-4637.2012.01437.x.
- Ipsilateral synkinesia involves the supplementary motor areaSalardini A, Narayanan NS, Arora J, Constable T, Jabbari B. Ipsilateral synkinesia involves the supplementary motor area. Neuroscience Letters 2012, 523: 135-138. PMID: 22759337, PMCID: PMC3836003, DOI: 10.1016/j.neulet.2012.06.060.
- Crossed synkinesia associated with long-term, intensive tennis playingRabin ML, Salardini A, Moghimi N, Jabbari B. Crossed synkinesia associated with long-term, intensive tennis playing. Clinical Neurology And Neurosurgery 2012, 114: 1014-1015. PMID: 22429565, DOI: 10.1016/j.clineuro.2012.01.028.
- A common symptom in two uncommon coexistent conditions: Glomus jugulare tumor and dysphagia lusoriaMittal SO, Jabbari B, Machado DG. A common symptom in two uncommon coexistent conditions: Glomus jugulare tumor and dysphagia lusoria. Clinical Neurology And Neurosurgery 2012, 114: 1193-1196. PMID: 22418048, DOI: 10.1016/j.clineuro.2012.02.031.
- Treatment of Refractory Pain with Botulinum Toxins—An Evidence‐Based ReviewJabbari B, Machado D. Treatment of Refractory Pain with Botulinum Toxins—An Evidence‐Based Review. Pain Medicine 2011, 12: 1594-1606. PMID: 21958302, DOI: 10.1111/j.1526-4637.2011.01245.x.
- Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot StudySafarpour D, Salardini A, Richardson D, Jabbari B. Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot Study. Pain Medicine 2010, 11: 1411-1414. PMID: 20609130, DOI: 10.1111/j.1526-4637.2010.00897.x.
- Botulinum Toxin A (Botox) for Treatment of Proximal Myofascial Pain in Complex Regional Pain Syndrome: Two CasesSafarpour D, Jabbari B. Botulinum Toxin A (Botox) for Treatment of Proximal Myofascial Pain in Complex Regional Pain Syndrome: Two Cases. Pain Medicine 2010, 11: 1415-1418. PMID: 20735753, DOI: 10.1111/j.1526-4637.2010.00929.x.
- Botulinum Neurotoxin‐A for Treatment of Refractory Neck Pain: A Randomized, Double‐Blind StudyMiller D, Richardson D, Eisa M, Bajwa RJ, Jabbari B. Botulinum Neurotoxin‐A for Treatment of Refractory Neck Pain: A Randomized, Double‐Blind Study. Pain Medicine 2009, 10: 1012-1017. PMID: 19594841, DOI: 10.1111/j.1526-4637.2009.00658.x.
- Botulinum neurotoxins in the treatment of refractory painJabbari B. Botulinum neurotoxins in the treatment of refractory pain. Nature Reviews Neurology 2008, 4: 676-685. PMID: 19043424, DOI: 10.1038/ncpneuro0948.
- Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic HypertensionBai Y, Jabbari B, Ye S, Campese VM, Vaziri ND. Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic Hypertension. American Journal Of Nephrology 2008, 29: 483-492. PMID: 19047792, PMCID: PMC2821947, DOI: 10.1159/000178817.
- Sensory physiology assessed by evoked potentials in survivors of poliomyelitisProkhorenko OA, Vasconcelos OM, Lupu VD, Campbell WW, Jabbari B. Sensory physiology assessed by evoked potentials in survivors of poliomyelitis. Muscle & Nerve 2008, 38: 1266-1271. PMID: 18816600, DOI: 10.1002/mus.21093.
- Relief of Intractable Pruritus After Administration of Botulinum Toxin A (Botox)Salardini A, Richardson D, Jabbari B. Relief of Intractable Pruritus After Administration of Botulinum Toxin A (Botox). Clinical Neuropharmacology 2008, 31: 303-306. PMID: 18836352, DOI: 10.1097/wnf.0b013e3181672225.
- Treatment of Painful Limbs/Moving Extremities with Botulinum Toxin Type A InjectionsEisa M, Singer C, Sengun C, Russel A, Jabbari B, Papapetropoulos S. Treatment of Painful Limbs/Moving Extremities with Botulinum Toxin Type A Injections. European Neurology 2008, 60: 104-106. PMID: 18552499, DOI: 10.1159/000138962.
- Botulinum toxin A: a new treatment option for multiple-sclerosis-related bladder overactivity?Jabbari B. Botulinum toxin A: a new treatment option for multiple-sclerosis-related bladder overactivity? Nature Reviews Neurology 2008, 4: 188-189. PMID: 18285749, DOI: 10.1038/ncpneuro0749.
- Physiology of the motor cortex in polio survivorsLupu VD, Danielian L, Johnsen JA, Vasconcelos OM, Prokhorenko OA, Jabbari B, Campbell WW, Floeter MK. Physiology of the motor cortex in polio survivors. Muscle & Nerve 2008, 37: 177-182. PMID: 17990291, DOI: 10.1002/mus.20913.
- Treatment of chronic low back pain with botulinum neurotoxinsJabbari B. Treatment of chronic low back pain with botulinum neurotoxins. Current Pain And Headache Reports 2007, 11: 352-358. PMID: 17894925, DOI: 10.1007/s11916-007-0217-1.
- Deep brain stimulation in Tourette's syndromeBajwa RJ, de Lotbinière AJ, King RA, Jabbari B, Quatrano S, Kunze K, Scahill L, Leckman JF. Deep brain stimulation in Tourette's syndrome. Movement Disorders 2007, 22: 1346-1350. PMID: 17580320, DOI: 10.1002/mds.21398.
- Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brainCampese VM, Sindhu RK, Ye S, Bai Y, Vaziri ND, Jabbari B. Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain. Brain Research 2006, 1134: 27-32. PMID: 17196179, DOI: 10.1016/j.brainres.2006.11.067.