Anselm Sommer, PhD
Associate Research Scientist in Pharmacology
Research & Publications
Biography
Coauthors
Selected Publications
- ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modesShi F, Mendrola JM, Sheetz JB, Wu N, Sommer A, Speer KF, Noordermeer JN, Kan ZY, Perry K, Englander SW, Stayrook SE, Fradkin LG, Lemmon MA. ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Reports 2021, 37: 109834. PMID: 34686333, PMCID: PMC8650758, DOI: 10.1016/j.celrep.2021.109834.
- Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in miceVeit M, Ahrens B, Seidel J, Sommer A, Bhakdi S, Reiss K. Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice. Life Science Alliance 2019, 2: e201900430. PMID: 31455669, PMCID: PMC6712283, DOI: 10.26508/lsa.201900430.
- ADAM10 sheddase activation is controlled by cell membrane asymmetryBleibaum F, Sommer A, Veit M, Rabe B, Andrä J, Kunzelmann K, Nehls C, Correa W, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K. ADAM10 sheddase activation is controlled by cell membrane asymmetry. Journal Of Molecular Cell Biology 2019, 11: 979-993. PMID: 30753537, PMCID: PMC6927242, DOI: 10.1093/jmcb/mjz008.
- Non-acylated Wnts Can Promote SignalingSpeer KF, Sommer A, Tajer B, Mullins MC, Klein PS, Lemmon MA. Non-acylated Wnts Can Promote Signaling. Cell Reports 2019, 26: 875-883.e5. PMID: 30673610, PMCID: PMC6429962, DOI: 10.1016/j.celrep.2018.12.104.
- Smoothening out the patchesSommer A, Lemmon MA. Smoothening out the patches. Science 2018, 362: 26-27. PMID: 30287647, PMCID: PMC6421564, DOI: 10.1126/science.aav1025.
- Anoctamin-6 regulates ADAM sheddase functionVeit M, Koyro K, Ahrens B, Bleibaum F, Munz M, Rövekamp H, Andrä J, Schreiber R, Kunzelmann K, Sommer A, Bhakdi S, Reiss K. Anoctamin-6 regulates ADAM sheddase function. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 2018, 1865: 1598-1610. PMID: 30327201, DOI: 10.1016/j.bbamcr.2018.08.011.
- Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 sheddingSommer A, Düppe M, Baumecker L, Kordowski F, Büch J, Chico J, Fritsch J, Schütze S, Adam D, Sperrhacke M, Bhakdi S, Reiss K. Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding. Oncotarget 2017, 5: 72584-72596. PMID: 29069811, PMCID: PMC5641154, DOI: 10.18632/oncotarget.19983.
- How membrane asymmetry regulates ADAM17 sheddase functionSommer A, Bhakdi S, Reiss K. How membrane asymmetry regulates ADAM17 sheddase function. Cell Cycle 2016, 15: 2995-2996. PMID: 27463373, PMCID: PMC5134693, DOI: 10.1080/15384101.2016.1211449.
- Phosphatidylserine exposure is required for ADAM17 sheddase functionSommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen F, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K. Phosphatidylserine exposure is required for ADAM17 sheddase function. Nature Communications 2016, 7: 11523. PMID: 27161080, PMCID: PMC4866515, DOI: 10.1038/ncomms11523.
- Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding ActivityDüsterhöft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Röseler J, Reiss K, Grötzinger J, Lorenzen I. Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity. Biochemistry 2015, 54: 5791-5801. PMID: 26348730, DOI: 10.1021/acs.biochem.5b00497.
- Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation*Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K. Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation*. Journal Of Biological Chemistry 2012, 287: 23678-23689. PMID: 22613720, PMCID: PMC3390642, DOI: 10.1074/jbc.m112.362756.
- Assessment of Endothelial Permeability and Leukocyte Transmigration in Human Endothelial Cell MonolayersLudwig A, Sommer A, Uhlig S. Assessment of Endothelial Permeability and Leukocyte Transmigration in Human Endothelial Cell Monolayers. 2011, 763: 319-332. PMID: 21874462, DOI: 10.1007/978-1-61779-191-8_22.