Amy Ahasic
Research & Publications
Biography
News
Research Summary
My research interest centers around obesity and metabolic pathways in critical illness. Because of their impact on cardiac and pulmonary function, such pathways may affect risk and prognosis in critical illness. I focus on acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and sepsis as common critical illness with systemic physiologic derangements and high morbidity and mortality. The relationship between obesity and ARDS is of particular interest. My current American Heart Association grant focuses on patient-oriented research of both phenotypic and genotypic markers relevant to metabolic pathways, including insulin-like growth factor (IGF) and adipokines, in acute lung injury.
Extensive Research Description
My research interest centers around obesity and metabolic pathways in critical illness. Because of their impact on cardiac and pulmonary function, such pathways may affect risk and prognosis in critical illness. I focus on acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and sepsis as common critical illness with systemic physiologic derangements and high morbidity and mortality. The relationship between obesity and ARDS is of particular interest. My current American Heart Association grant focuses on patient-oriented research of both phenotypic and genotypic markers relevant to metabolic pathways, including insulin-like growth factor (IGF) and adipokines, in acute lung injury.
I am also interested in the aging ICU population, and their functional and cognitive outcomes after critical illness. This extends to the cognitive-metabolic connection linking various metabolic phenomena such as obesity and insulin resistance to cognitive impairment and delirium, particularly in older adults. Delirium in the ICU is a common phenomenon for which age is a major risk factor, and its occurrence has significant impacts on morbidity and mortality.
Yale MICU Biorepository project: Principal Investigator on this initiative to collect clinical data and biologic specimens from a broad range of critically ill patients. We have enrolled approximately 700 patients to date.
Coauthors
Research Interests
Aging; Critical Care; Delirium; Epidemiology; Obesity; Occupational Medicine; Respiratory Distress Syndrome; Pulmonary Medicine; Sepsis; Environmental Medicine; Acute Lung Injury
Public Health Interests
Environmental Health; Genetics, Genomics, Epigenetics; Obesity; Occupational Health; Respiratory Disease/Infections
Selected Publications
- Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*. Critical Care Medicine 2015, 43: 2651-2659. PMID: 26427594, PMCID: PMC4651824, DOI: 10.1097/ccm.0000000000001314.
- Personalized Critical Care Medicine: How Far Away Are We?Ahasic AM, Christiani DC. Personalized Critical Care Medicine: How Far Away Are We? Seminars In Respiratory And Critical Care Medicine 2015, 36: 809-822. PMID: 26595041, DOI: 10.1055/s-0035-1564852.
- Functional status after critical illness: agreement between patient and proxy assessmentsAhasic AM, Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: agreement between patient and proxy assessments. Age And Ageing 2014, 44: 506-510. PMID: 25324334, PMCID: PMC4411220, DOI: 10.1093/ageing/afu163.
- Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and MortalityAhasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC. Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality. PLOS ONE 2014, 9: e89170. PMID: 24586568, PMCID: PMC3929660, DOI: 10.1371/journal.pone.0089170.
- MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injuryMannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l604-l619. PMID: 24487387, PMCID: PMC3962628, DOI: 10.1152/ajplung.00272.2013.
- Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary originTejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.
- IGF1 and IGFBP3 in acute respiratory distress syndromeAhasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. European Journal Of Endocrinology 2011, 166: 121-129. PMID: 22004906, PMCID: PMC3757506, DOI: 10.1530/eje-11-0778.
- The future of occupationally related diffuse lung disease.Nuernberg AM, Christiani DC. The future of occupationally related diffuse lung disease. Seminars In Respiratory And Critical Care Medicine 2008, 29: 680-4. PMID: 19221966, DOI: 10.1055/s-0028-1101278.
- Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure.Nuernberg AM, Boyce PD, Cavallari JM, Fang SC, Eisen EA, Christiani DC. Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure. Journal Of Occupational And Environmental Medicine / American College Of Occupational And Environmental Medicine 2008, 50: 182-9. PMID: 18301175, DOI: 10.1097/JOM.0b013e31815cf6cc.
- Self-inflicted abdominal stab wounds.Abdullah F, Nuernberg A, Rabinovici R. Self-inflicted abdominal stab wounds. Injury 2003, 34: 35-9. PMID: 12531375, DOI: 10.1016/s0020-1383(02)00084-0.