Zachary Harvanek, MD/PhD
he/him/his
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About
Research
Publications
2024
Childhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 1-14. PMID: 38762606, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass indexGreater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample. Biological Psychiatry 2024, 95: s41. DOI: 10.1016/j.biopsych.2024.02.104.Peer-Reviewed Original Research353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity
Harvanek Z, Zhang X, Xu K, Sinha R. 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity. Biological Psychiatry 2024, 95: s244. DOI: 10.1016/j.biopsych.2024.02.852.Peer-Reviewed Original Research
2023
Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsThe Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health
Harvanek Z, Boks M, Vinkers C, Higgins-Chen A. The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health. Biological Psychiatry 2023, 94: 694-705. PMID: 36764569, PMCID: PMC10409884, DOI: 10.1016/j.biopsych.2023.02.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Harvanek ZM, Fogelman N, Xu K, Sinha R. Psychological and biological resilience modulates the effects of stress on epigenetic aging. Translational Psychiatry 2021, 11: 601. PMID: 34839356, PMCID: PMC8627511, DOI: 10.1038/s41398-021-01735-7.Peer-Reviewed Original ResearchConceptsEmotion regulationResilience factorsCumulative stressWorse emotion regulationPoor emotion regulationPsychological resilience factorsNegative long-term health consequencesCommunity sampleEffects of stressBiological age accelerationPhysical outcomesMore stressBehavioral factorsChronic stressGrimAge accelerationHealth consequencesStress physiologyLong-term health consequencesEpigenetic agingPhysiologic measuresHealthy populationFinal modelAge accelerationAgingRelationship
2019
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron CM, Chakraborty TS, Chung BY, Harvanek ZM, Holme KJ, Johnson JC, Lyu Y, Munneke AS, Pletcher SD. Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception. Annual Review Of Physiology 2019, 82: 1-23. PMID: 31635526, PMCID: PMC7012701, DOI: 10.1146/annurev-physiol-021119-034440.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSensory perceptionDecision-making behaviorTime perceptionLine of researchSocial perceptionNeural mechanismsSensory cuesFood perceptionThreat perceptionPerceptive experienceNeuronal mechanismsAge-related diseasesPerceptionNovel therapeutic targetAge-related physiologyTherapeutic targetGroups of neuronsInput influencesCuesPhysiologySensory neuronsAgingOrganismalGeneral thoughtsHuman healthA Structured Approach to Introducing Residents to Group Therapy Leadership
Harvanek ZM, Millard H. A Structured Approach to Introducing Residents to Group Therapy Leadership. Academic Psychiatry 2019, 43: 652-653. PMID: 31485999, DOI: 10.1007/s40596-019-01112-z.Peer-Reviewed Educational Materials
2017
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
Henderson D, Huebner C, Markowitz M, Taube N, Harvanek ZM, Jakob U, Knoefler D. Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin? Redox Biology 2017, 14: 386-390. PMID: 29055282, PMCID: PMC5647470, DOI: 10.1016/j.redox.2017.10.003.Peer-Reviewed Original ResearchConceptsC. elegansC. elegans larvaeRedox stateVivo redox stateReduced redox statePoikilothermic organismsDevelopmental temperatureLifespan extensionRedox statusMechanistic underpinningsBeneficial long-term consequencesElegansExpression levelsOrganismsVivo redox statusWormsRedox levelsCaenorhabditisLifespanPeroxiredoxinsGrowth temperatureLarvaeAnimalsUpregulationEffect of temperaturePerceptive costs of reproduction drive ageing and physiology in male Drosophila
Harvanek ZM, Lyu Y, Gendron CM, Johnson JC, Kondo S, Promislow DEL, Pletcher SD. Perceptive costs of reproduction drive ageing and physiology in male Drosophila. Nature Ecology & Evolution 2017, 1: 0152. PMID: 28812624, PMCID: PMC5657004, DOI: 10.1038/s41559-017-0152.Peer-Reviewed Original ResearchLife-history traitsReproductive costsBenefits of matingPopulation genetic studiesCost of reproductionAct of matingMale Drosophila melanogasterOrganismal fitnessDrosophila melanogasterReproductive effortMale DrosophilaNatural selectionStress resistancePheromone perceptionPhysiological constraintsGenetic studiesMechanistic basisKey survivalPhysiological costsReproductionFat storageMolecular frameworkMatingTraitsImportant insights
Academic Achievements and Community Involvement
Links & Media
News
- May 20, 2024Source: Journal of Behavioral Medicine
Childhood Adversity, Accelerated GrimAge, and Associated Health Consequences
- July 24, 2023Source: Neurobiology of Stress
Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
- July 19, 2023
2023 Residents, Fellows Honored at Annual Commencement Ceremonies
- June 07, 2023
Harvanek Receives Yale Physician Scientist Development Award