2022
Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, Yang L, Fei F, Dai S, Chen L, Zheng Y, Xu C, Fang J, Wang S, Chen Z, Wang Y. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Reports 2022, 41: 111798. PMID: 36516780, DOI: 10.1016/j.celrep.2022.111798.Peer-Reviewed Original ResearchConceptsGeneralized seizuresActivity-dependent labeling techniquesInterictal periodSeizure developmentIP-enabledNeuronal ensemblesPiriform cortexPotential therapeutic targetCircuit rearrangementsOptogenetic activationHistological evidenceFocal seizuresIctal eventsSeizure generationControlling coherenceCellular mechanismsEpileptic networkSeizuresTherapeutic targetInterictal statePiriformThe role of Na+‐K+‐ATPase in the epileptic brain
Sun J, Zheng Y, Chen Z, Wang Y. The role of Na+‐K+‐ATPase in the epileptic brain. CNS Neuroscience & Therapeutics 2022, 28: 1294-1302. PMID: 35751846, PMCID: PMC9344081, DOI: 10.1111/cns.13893.Peer-Reviewed Original Research
2020
HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window
Zhao J, Zheng Y, Liu K, Chen J, Lai N, Fei F, Shi J, Xu C, Wang S, Nishibori M, Wang Y, Chen Z. HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window. Neurotherapeutics 2020, 17: 710-721. PMID: 31802434, PMCID: PMC7283397, DOI: 10.1007/s13311-019-00815-3.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Anti-HMGB1 mAbStatus epilepticusTherapeutic targetLife-threatening neurological emergencyToll-like receptor 4 (TLR4)-dependent pathwayAnti-HMGB1 monoclonal antibodyNeutralization of HMGB1Plasma HMGB1 levelsMobility group box 1Severity of seizure activityExogenous high mobility group box 1Incidence of SENonrefractory SEHMGB1 levelsPredictive biomarkersTherapeutic responseNeurological emergencyTherapeutic windowBox 1Seizure activityMonoclonal antibodiesPharmacological therapeuticsSE periodEpilepticus