Wenxiang Cao, PhD
Research ScientistCards
About
Research
Publications
2026
A direct, real-time, spectrophotometric assay for measuring ENPP1-catalyzed cGAMP hydrolysis
Michalchik M, Lombardo Z, Braddock D, Cao W, De La Cruz E. A direct, real-time, spectrophotometric assay for measuring ENPP1-catalyzed cGAMP hydrolysis. Journal Of Biological Chemistry 2026, 302: 113078. PMID: 42055331, PMCID: PMC13223937, DOI: 10.1016/j.jbc.2026.113078.Peer-Reviewed Original Research
2025
Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy
Michalchik M, Potchernikov T, Lester E, Braddock D, Cao W, De La Cruz E. Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy. Journal Of Biological Chemistry 2025, 301: 110558. PMID: 40769408, PMCID: PMC12446537, DOI: 10.1016/j.jbc.2025.110558.Peer-Reviewed Original Research
2024
Bending stiffness of Toxoplasma gondii actin filaments
Cao W, Sladewski T, Heaslip A, De La Cruz E. Bending stiffness of Toxoplasma gondii actin filaments. Journal Of Biological Chemistry 2024, 301: 108101. PMID: 39706262, PMCID: PMC11786770, DOI: 10.1016/j.jbc.2024.108101.Peer-Reviewed Original ResearchHigh-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations
Xu X, Cao W, Swift M, Pandit N, Huehn A, Sindelar C, De La Cruz E, Hanein D, Volkmann N. High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations. Communications Chemistry 2024, 7: 164. PMID: 39079963, PMCID: PMC11289367, DOI: 10.1038/s42004-024-01243-x.Peer-Reviewed Original ResearchQuantitative correlation of ENPP1 pathogenic variants with disease phenotype
Ansh A, Stabach P, Ciccone C, Cao W, De La Cruz E, Sabbagh Y, Carpenter T, Ferreira C, Braddock D. Quantitative correlation of ENPP1 pathogenic variants with disease phenotype. Bone 2024, 186: 117136. PMID: 38806089, PMCID: PMC11227391, DOI: 10.1016/j.bone.2024.117136.Peer-Reviewed Original ResearchPublisher Correction: Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex
Chavali S, Chou S, Cao W, Pollard T, De La Cruz E, Sindelar C. Publisher Correction: Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nature Communications 2024, 15: 2354. PMID: 38491023, PMCID: PMC10943100, DOI: 10.1038/s41467-024-46804-9.Commentaries, Editorials and LettersCryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex
Chavali S, Chou S, Cao W, Pollard T, De La Cruz E, Sindelar C. Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nature Communications 2024, 15: 2059. PMID: 38448439, PMCID: PMC10918085, DOI: 10.1038/s41467-024-46179-x.Peer-Reviewed Original ResearchDistinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Sexton J, Potchernikov T, Bibeau J, Casanova-Sepúlveda G, Cao W, Lou H, Boggon T, De La Cruz E, Turk B. Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail. Nature Communications 2024, 15: 1426. PMID: 38365893, PMCID: PMC10873347, DOI: 10.1038/s41467-024-45878-9.Peer-Reviewed Original Research
2023
Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change
Sun Z, Yadav V, Amiri S, Cao W, De La Cruz E, Murrell M. Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change. European Journal Of Cell Biology 2023, 103: 151379. PMID: 38168598, PMCID: PMC12128893, DOI: 10.1016/j.ejcb.2023.151379.Peer-Reviewed Original ResearchCooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments
Cao W, Taylor E, De La Cruz E. Cooperative ligand binding to a double-stranded Ising lattice—Application to cofilin binding to actin filaments. PNAS Nexus 2023, 2: pgad331. PMID: 37885622, PMCID: PMC10599439, DOI: 10.1093/pnasnexus/pgad331.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Get In Touch
Contacts
Mailing Address
Molecular Biophysics and Biochemistry
266 Whitney Ave. , 335 Bass Building
New Haven, CT 06511
United States