Demetrios Braddock, MD, PhD
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Biography
Demetrios Braddock was born in Tennessee, educated at the University of Chicago, trained at the NIH in Anatomic Pathology and Biophysical Chemistry, and came to Yale in 2004. He practices Hematopathology and leads a laboratory that studies the ENPP enzymes – a family of extracellular enzymes that create small molecules in the extracellular environment that regulate organismal homeostasis in processes such as hemostasis, bone mineralization, and vascular development. We are especially interested in a rare disease of lethal vascular calcifications called 'Generalized Arterial Calcification of Infancy' (GACI) associated with ENPP1 deficiency, and designed and validated an enzyme therapy that was curative in a mouse model of GACI. We are now moving this therapy into patients in collaboration with a company we founded (Inozyme Pharma) and clinical trials are now underway in diseases associated with ENPP1 and ABCC6 deficiency (ClinicalTrials.gov: NCT04686175 & NCT05030831). We have also identified a form of early onset osteoporosis associated with ENPP1 deficiency, and are investigating the role of ENPP1 in low bone mass and increased tissue calcification, a medical condition called 'Paradoxical Mineralization' which occurs in the general medical population in conditions such as aging and chronic kidney disease.
Education & Training
- FellowYale University School of Medicine (2010)
- ResidentNational Cancer Institute, NIH, Laboratory of Pathology (2000)
- MDUniversity of Chicago Pritzker School of Medicine (1996)
- PhDUniversity of Chicago (1994)
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Yale 2022 Faculty Innovation Award | Yale University | 2022 |
Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Braddock Lab
- Dean's Workshops
- Discovery to Cure Internship
- Experimental Pathology Graduate Program
- Genomics, Genetics, and Epigenetics
- Hematopathology
- Hematopathology
- Molecular Medicine, Pharmacology, and Physiology
- Pathology
- Pathology Research
- Prostate & Urologic Cancers Program
- Structural Biology
- Surgical Pathology
- Vascular Biology and Therapeutics Program
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Ventures