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INFORMATION FOR

Shuta Ishibe, MD

Professor of Medicine (Nephrology); Director, Undergraduate Summer Research Program for Nephrology; Director, Research Fellowship; Director for Educational Enrichment, George M. O'Brien Center, Nephrology

Appointments

Biography

.My major area of research interest includes 1) the endocytic process in podocytes. 2) cell matrix regulation in podocytes. Our laboratory has identified the critical role of the clathrin coated endocytic processes in the development and maintenance of podocytes. In-vivo animal models with conventional or conditional ablation of genes implicated for endocytosis, such as synaptojanin, endophilin, and dynamin develop severe proteinuria and foot process effacement. By utilizing fluorescently tagged proteins, we have visualized these proteins along with genes implicated to cause human nephrotic syndrome (CD2AP, Myo1e, Nephrin) lie at the interface of endocytosis and actin cytoskeleton. One of the major goals of the laboratory is investigating and further understanding the critical factors that are being endocytosed in podocytes. We have also sought to examine the role of cell matrix interactions by providing mechanistic insight on focal adhesion proteins and integrins, which govern podocyte cell adhesion and movement during health and disease states, using mouse genetic models of disease.

Education & Training

  • Resident
    Parkland Memorial Hospital (2000)
  • Internship
    Parkland Memorial Hospital (1998)
  • MD
    University of Texas Southwestern Medical School (1997)
  • BA
    Rice University (1993)

Honors & Recognition

AwardAwarding OrganizationDate
Distinguished Researcher AwardAmerican Society of Nephrology2020
MemberAmerican Society of Clinical Investigation2020
GottschalkAmerican Society of Nephrology2007
Alpha Omega AlphaUniversity of Texas at Southwestern1997
Cum LaudeRice University1993
Outstanding Male Athlete, Bob Quin AwardRice University1993

Professional Service

OrganizationRoleDate
American Society for Clinical InvestigationMember2020 - Present
American Society of Nephrology, Kidney Week AbstractsReviewer2020
American Society of Nephrology, Kidney Week Abstracts, Podocyte BiologyChair2019
Kidney 360Associate Editor2019 - Present
Yale Scholar AwardsCommittee Member2018 - 2021
NIH / NIDDK PBKDMember2018 - 2021
Kidney Precision Medicine Project (KPMP) Pool RFAReviewer2018 - 2020
NIH / NIDDK PBKDAd-hoc reviewer2017
Kidney Precision Medicine Project (KPMP) Pool RFAReviewer2017
American Society of Nephrology, Kidney Week AbstractsReviewer2016 - 2018
Veterans Affairs Merit AwardAd-hoc reviewer2016
Veterans Affairs, Merit AwardGrant Reviewer2016
Veterans Affairs Merit AwardAd-hoc reviewer2015 - 2016
NephCure NEPTUNE Ancillary Studies AwardGrant Reviewer2015 - 2016
NIH / NIDDK PBKDAd-hoc reviewer2015
American Society of Nephrology, Kidney Week Program, GlomerularCommittee Member2015
American Society of Nephrology, Kidney Week AbstractsReviewer2011 - 2013
Nature Medicine, The Journal of Clinical Investigation, Journal of American Society of Nephrology, Kidney International, American Journal of Physiology, Molecular and Cellular Biology, Proceedings of the National Academy of Sciences, PLOS-One, FASEBReviewer2005 - Present
American Society of NephrologyMember2002

Departments & Organizations