Shuta Ishibe, MD
Cards
About
Titles
Professor of Medicine (Nephrology)
Director, Undergraduate Summer Research Program for Nephrology; Director, Research Fellowship; Director for Educational Enrichment, George M. O'Brien Center, NephrologyBiography
My major area of research interest include the endocytic process and matrix regulation in podocytes.
Our laboratory has identified the critical role of the clathrin coated endocytic processes in the development and maintenance of podocytes. In-vivo animal models with conventional or conditional ablation of genes implicated for endocytosis, such as synaptojanin, endophilin, and dynamin develop severe proteinuria and foot process effacement. By utilizing fluorescently tagged proteins, we have visualized these proteins along with genes implicated to cause human nephrotic syndrome (CD2AP, Myo1e, Nephrin) lie at the interface of endocytosis and actin cytoskeleton. One of the major goals of the laboratory is investigating and further understanding the critical factors that are being endocytosed in podocytes. We have also sought to examine the role of cell matrix interactions by providing mechanistic insight on focal adhesion proteins and integrins, which govern podocyte cell adhesion and movement during health and disease states, using mouse genetic models of disease.
Appointments
Nephrology
ProfessorPrimaryCellular & Molecular Physiology
Associate Professor on TermSecondary
Other Departments & Organizations
Education & Training
- Resident
- Parkland Memorial Hospital (2000)
- Internship
- Parkland Memorial Hospital (1998)
- MD
- University of Texas Southwestern Medical School (1997)
- BA
- Rice University (1993)
Research
Academic Achievements and Community Involvement
Links & Media
News
- February 27, 2024
Study Led by Yale Pathologists Shows Thrombotic Microangiopathy Should Be Considered Life-threatening Following Acute Diethylene Glycol Exposure
- August 07, 2023
The Role of APOL1 Gene Variants in Kidney Disease: A Q&A with Madhav Menon and Shuta Ishibe
- January 11, 2023
Discoveries & Impact (January 2023)
- December 07, 2022
New Professors in Department of Internal Medicine (December 2022)