2011
Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate
Li W, Gu Y, James M, Hines R, Simpson P, Langaee T, Stacpoole P. Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate. Drug Metabolism And Disposition 2011, 40: 232-239. PMID: 22028318, PMCID: PMC3263939, DOI: 10.1124/dmd.111.041533.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAmino Acid SubstitutionAntineoplastic AgentsChildCytoplasmDichloroacetic AcidDrugs, InvestigationalFemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGlutathione TransferaseHalogenationHumansLiverMaleMiddle AgedMitochondria, LiverPolymorphism, Single NucleotideSubstrate SpecificityYoung AdultConceptsGSTZ1 activityHuman liverProtein expressionAge 74 yearsInfluence of haplotypeAge 7 yearsAge-dependent mannerAge-related increaseRole of haplotypesWeeks' gestationHuman liver developmentNeonatal onsetAge-related differencesLactic acidosisInvestigational drugsSolid tumorsGSTZ1 protein expressionPostnatal expressionSubject ageLevel of expressionFetal liverLiverGSTZ1 expressionExpression levelsTyrosine catabolism
1994
The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression
Hines R, Cashman J, Philpot R, Williams D, Ziegler D. The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression. Toxicology And Applied Pharmacology 1994, 125: 1-6. PMID: 8128486, DOI: 10.1006/taap.1994.1042.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFlavinsGene Expression Regulation, EnzymologicHumansOxygenasesSpecies SpecificityStereoisomerismSubstrate SpecificityXenobioticsConceptsFlavin-containing monooxygenaseRegulation of expressionSpecies-specific differencesFlavin-Containing MonooxygenasesMixture of cisSubstrate specificityMammalian speciesToxicant susceptibilitySoft nucleophilesMolecular characterizationEnzyme's abilitySecondary alkylMultiple tissuesEarly stepsActive derivativesEnzyme systemUnique stereoselectivityFlavin enzymesHuman FMO3Toxic intermediatesFMO expressionThiocarbamideSpeciesChemical toxicityCytochrome P450
1981
The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenase.
Prough R, Freeman P, Hines R. The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenase. Journal Of Biological Chemistry 1981, 256: 4178-4184. PMID: 7217078, DOI: 10.1016/s0021-9258(19)69416-0.Peer-Reviewed Original Research