2019
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams A, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt M, Lakkis F. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Journal Of Clinical Investigation 2019, 130: 287-294. PMID: 31763998, PMCID: PMC6934226, DOI: 10.1172/jci125773.Peer-Reviewed Original ResearchConceptsHost DCT cell responsesDonor antigensT cellsMHC-peptide complexesActivation of host T cellsAlloantigens to T cellsEffector T cell responsesCD8+ T cellsDonor MHC moleculesHost T cellsDifferentiation to effectorKidney transplant modelSecondary lymphoid organsSelf-MHC moleculesAntigen presentation pathwayAcute rejectionAllograft rejectionDendritic cellsIndirect presentationTransplantation modelAntigen presentationLymphoid organsPresentation pathwayIntravital microscopy
2014
TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections.
Tieu R, Amancha P, Villinger F, Byrareddy S. TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections. 2014, 1 PMID: 26539564, PMCID: PMC4629856.Peer-Reviewed Original ResearchChronic viral infectionsTim-3Inhibitory receptorsChronic viral infection modelsEffector T cell responsesExpression of Tim-3Viral infectionCo-inhibitory moleculesT cell responsesCTLA-4PD-1Immune checkpointsCo-stimulatorySoluble factorsInfection modelTherapeutic targetImmunotherapyTumorReceptorsInfectionViral infection modelCancerChronicallyComplex mechanisms