2022
SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network
Li W, Yang S, Xu P, Zhang D, Tong Y, Chen L, Jia B, Li A, Lian C, Ru D, Zhang B, Liu M, Chen C, Fu W, Yuan S, Gu C, Wang L, Li W, Liang Y, Yang Z, Ren X, Wang S, Zhang X, Song Y, Xie Y, Lu H, Xu J, Wang H, Yu W. SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network. EBioMedicine 2022, 76: 103861. PMID: 35124429, PMCID: PMC8811534, DOI: 10.1016/j.ebiom.2022.103861.Peer-Reviewed Original ResearchConceptsHuman identical sequencesRNA elementsHuman genomeSARS-CoV-2 genomeHyaluronan synthase 2Chromatin immunoprecipitation assaysDistant genesSequence similarityGenomic fragmentsSequence identityTarget lociGenomic interactionsMiRNA precursorsH3K27ac enrichmentSARS-CoV-2Identical sequencesBioinformatics analysisImmunoprecipitation assaysGenomeGene expressionHEK293TQuantitative RT-PCRShort sequencesGenesHost enhancement
2019
Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks
Li J, Li Y, Li W, Luo H, Xi Y, Dong S, Gao M, Xu P, Zhang B, Liang Y, Zou Q, Hu X, Peng L, Zou D, Wang T, Yang H, Jiang C, Peng S, Wu F, Yu W. Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. Genome Research 2019, 29: 270-280. PMID: 30670627, PMCID: PMC6360814, DOI: 10.1101/gr.240606.118.Peer-Reviewed Original ResearchConceptsWhole-genome bisulfite sequencingAberrant DNA methylationDNA methylationCell identityPredictor of gene expressionGenome-wide DNA methylationWhole-genome DNA methylationAberrant DNA methylation patternsDNA methylation patternsExpression of genes associated with immunityGenes associated with immunityAltering cell identityGene bodiesGC-richGenomic variationRepetitive regionsBisulfite sequencingMethylation patternsMethylation differencesGene expressionModulate expressionImmune surveillance networkLiver cancer developmentSequenceCancer development