UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner
Xu P, Zhang L, Xiao Y, Li W, Hu Z, Zhang R, Li J, Wu F, Xi Y, Zou Q, Wang Z, Guo R, Ma H, Dong S, Xiao M, Yang Z, Ren X, Wei C, Yu W. UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner. Human Molecular Genetics 2021, 30: 2110-2122. PMID: 34196368, DOI: 10.1093/hmg/ddab178.Peer-Reviewed Original ResearchConceptsU snRNAsSplicing factorsDNA methylation maintenanceAlternative splicing eventsFunctions of UHRF1RNA splicing regulationAlternative RNA splicingDNA damage repairU2 snRNAMethylation maintenanceProtein interactomeRNA metabolismSplicing regulationRNA splicingSplicing eventsSpliceosome componentsAlternative splicingRNA interactomeUHRF1Chromatin configurationBinding preferencesCell cycleMolecular basisBiological processesMethylation status