Nicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients
Steriade C, Thomas S, Xu F, Ahituv A, Hanin A, Pleshkevich M, Hwang S, Ramirez A, Foreman B, Yoo J, Eka O, Kellogg M, Oliger A, Wainwright M, Morales M, Gaspard N, Hirsch L, Devinsky O, Saxena D. Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients. Epilepsia 2025 PMID: 40387216, DOI: 10.1111/epi.18450.Peer-Reviewed Original ResearchChronic epilepsy patientsSE patientsStatus epilepticusEpilepsy patientsChronic epilepsyPre-existing epilepsyFuture treatment strategiesDisease time pointsInflammatory cytokine levelsFecal microbiomeMicrobiome structureLongitudinal cohort studyMicrobiome featuresCytokine levelsEffective therapyCohort studyTreatment strategiesInflammatory cytokinesSE resolutionInflammatory responseCritical illnessPatientsGut dysbiosisMortality rateClinical treatmentIdentification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling
Guillemaud M, Chavez M, Kobeissy F, Vezzani A, Jimenez A, Basha M, Batra A, Demeret S, Eka O, Eschbach K, Foreman B, Gaspard N, Gerard E, Gofton T, Haider H, Hantus S, Howe C, Jongeling A, Kalkach-Aparicio M, Kandula P, Kazazian K, Kim M, Lai Y, Marois C, Mellor A, Mohamed W, Morales M, Pimentel C, Ramirez A, Steriade C, Struck A, Taraschenko O, Torcida Sedano N, Wainwright M, Yoo J, Wang K, Navarro V, Hirsch L, Hanin A. Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling. Neurology Neuroimmunology & Neuroinflammation 2025, 12: e200403. PMID: 40334176, PMCID: PMC12063244, DOI: 10.1212/nxi.0000000000200403.Peer-Reviewed Original ResearchConceptsCryptogenic new-onset refractory status epilepticusClusters of patientsCytokine profileInflammatory markersNew-onset refractory status epilepticusTarget specific inflammatory pathwaysInitiation of immunotherapyResponse to immunotherapyRefractory status epilepticusPersonalized therapeutic strategiesGroup of patientsStatistically significant elevationTime of administrationProtein pathway analysisInflammatory subgroupsMultiple immunotherapiesDifferential treatment responseRefractory SEC patientsImprove patient outcomesAutoimmune mechanismsImmune dysregulationClinical featuresCytokine levelsAutoimmune processOn‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy
Feys O, Wens V, Depondt C, Rikir E, Gaspard N, Van Paesschen W, Aeby A, Bodart O, Carrette E, Holmes N, Brookes M, Ferez M, Corvilain P, De Tiège X. On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy. Epilepsia 2025 PMID: 40317508, DOI: 10.1111/epi.18439.Peer-Reviewed Original ResearchInterictal epileptiform dischargesOptically pumped magnetometersTemporal lobe epilepsyOn-scalp magnetoencephalographyLobe epilepsyRefractory temporal lobe epilepsySignal-to-noise ratioInvestigate temporal lobe epilepsySurgical resection cavityExtratemporal lobe epilepsyOn-scalpResection cavityEpileptiform dischargesPatientsEpilepsyTemporal lobeMEG recordingsMagnetoencephalographyMagnetometerAmplitudeSingle-pulse electrical stimulations reduce the number of seizures during stereo-electroencephalography
Feys O, Rikir E, Legros B, Sculier C, Schuind S, Wens V, De Tiège X, Gaspard N. Single-pulse electrical stimulations reduce the number of seizures during stereo-electroencephalography. Brain Stimulation 2025, 18: 768-769. PMID: 40216304, DOI: 10.1016/j.brs.2025.04.005.Peer-Reviewed Original ResearchThe effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study
Devroey M, Orbegozo Cortes D, Gaspard N, Foucart J, Preiser J, Taccone F. The effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study. Journal Of Critical Care 2025, 87: 155044. PMID: 40036993, DOI: 10.1016/j.jcrc.2025.155044.Peer-Reviewed Original ResearchConceptsMusic intervention groupMusic interventionMV weaningIntervention groupVisual analog scaleCalm musicMusicCritically ill patientsAnxiety levelsIll patientsPilot studyMechanical ventilationReduce anxietyCriticismCortisol blood levelsEfficacy of hypnosisDistressing symptomsEffects of hypnosisHypnosis groupInclusion criteriaPrimary outcomeEligible patientsInterventionSpontaneous breathing trialAnalog scaleAdherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study.
Bellante F, Santos S, Gérard L, Jacquet L, Piagnerelli M, Taccone F, Thooft A, Wittebole X, Legros B, Gaspard N. Adherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study. Journal Of Clinical Neurophysiology 2025 PMID: 39810297, DOI: 10.1097/wnp.0000000000001143.Peer-Reviewed Original ResearchGroup of patientsAcute brain injuryClinical seizuresElectrographic seizuresStatus epilepticusClinical factorsEEG monitoringSociety recommendationsMulticenter prospective observational studySeizure riskAmerican Clinical Neurophysiology SocietyMental statusCritically ill adult patientsRefractory status epilepticusConvulsive status epilepticusProspective multicentre studyDetection of electrographic seizuresIll adult patientsLow-risk groupIntensive care unitTime of dischargeBrain injuryPrimary admission diagnosisPatient selectionAdult patientsAge‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias‐Moeller R, Eschbach K, Gofton T. Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry. Epilepsia 2025, 66: e35-e40. PMID: 39804054, PMCID: PMC11908657, DOI: 10.1111/epi.18260.Peer-Reviewed Original ResearchConceptsFamily RegistryFebrile infection-related epilepsy syndromeAnti-seizure medicationsSelf-reported qualityQuality of lifePediatric patientsLong-term outcomesWeb-based registryProdromal symptomsAnxiety outcomesPoor cognitionAnti-seizure medication useClinical presentationSeizure burdenAdult survivorsProdromal presentationInternational web-based registryBad moodRegistryAge groupsRefractory status epilepticusAdultsCognitive outcomesOutcomesAge-associated differences
2024
Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation
Feys O, Schuind S, Sculier C, Rikir E, Legros B, Gaspard N, Wens V, De Tiège X. Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation. Epilepsia 2024, 66: 503-517. PMID: 39641210, DOI: 10.1111/epi.18183.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneCortico-corticalRefractory focal epilepsyElectrical stimulationBrain structuresEvoked responsesEffective connectivityEpileptogenic networksFocal epilepsyIntracranial EEGCortical/subcortical structuresComplex spatiotemporal dynamicsIntracranial recordingsStimulationMEG signalsLocation of electrodesMagnetoencephalographyVariability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence
Feys O, Wens V, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Variability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence. Annals Of Clinical And Translational Neurology 2024, 11: 2645-2656. PMID: 39370736, PMCID: PMC11514933, DOI: 10.1002/acn3.52179.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneStereo-electroencephalography recordingsStereo-electroencephalographyEpileptogenic networksReceiver operating characteristic curveCortico-corticalOperating characteristics curveOccurrence of seizuresEpileptiform dischargesSeizure frequencyEpilepsy surgerySeizuresSeizure occurrenceCharacteristic curveSpearman correlationElectrical stimulationTime courseCCEPStimulationConnectivity modificationsSurgeryPatientsInfusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitation