Nicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2024
Variability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence
Feys O, Wens V, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Variability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence. Annals Of Clinical And Translational Neurology 2024, 11: 2645-2656. PMID: 39370736, PMCID: PMC11514933, DOI: 10.1002/acn3.52179.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneStereo-electroencephalography recordingsStereo-electroencephalographyEpileptogenic networksReceiver operating characteristic curveCortico-corticalOperating characteristics curveOccurrence of seizuresEpileptiform dischargesSeizure frequencyEpilepsy surgerySeizuresSeizure occurrenceCharacteristic curveSpearman correlationElectrical stimulationTime courseCCEPStimulationConnectivity modificationsSurgeryPatientsInfusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationComplications during and after ICU stay are associated with increased mortality after status epilepticus
Damien C, Yuan F, Legros B, Gaspard N. Complications during and after ICU stay are associated with increased mortality after status epilepticus. Clinical Neurology And Neurosurgery 2024, 246: 108554. PMID: 39278005, DOI: 10.1016/j.clineuro.2024.108554.Peer-Reviewed Original ResearchIntensive care unitStatus epilepticusIntensive care unit stayRisk factors of mortalityAssociated with increased mortalityMortality rateTertiary medical centerRetrospective cohort studyFactors of mortalityBurden of comorbiditiesIntensive care unit deathPost-ICU deathPrimary outcome measureIntensive care unit dischargeHigher mortality rateSE episodesICU complicationsNeurological emergencyCare unitRisk factorsOutcome measuresMedical CenterMortalityEpilepticusWardCommunication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K, Gofton T. Communication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry. Epilepsy & Behavior 2024, 160: 110023. PMID: 39241640, DOI: 10.1016/j.yebeh.2024.110023.Peer-Reviewed Original ResearchPalliative care servicesFamily RegistryCare servicesImprove overall carePrognostic conversationsAcute hospitalsOverall careEpidemiological informationConsensus definitionPhysician-patient-family relationshipRegistryNORSE/FIRESMinority of patientsPrognostic informationSatisfactionFamilySystematic effortRecovery processServicesCarePatientsHospitalPrevalenceQualityEpilepsy syndromesIn-hospital Management of Status Epilepticus: Does Uniformity Mean Quality?
Gaspard N. In-hospital Management of Status Epilepticus: Does Uniformity Mean Quality? Epilepsy Currents 2024, 24: 387-389. PMID: 39544726, PMCID: PMC11558722, DOI: 10.1177/15357597241261917.Peer-Reviewed Original ResearchEEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppressionQuantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome
van Putten M, Ruijter B, Horn J, van Rootselaar A, Tromp S, van Kranen-Mastenbroek V, Gaspard N, Hofmeijer J, Investigators F. Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome. Neurology 2024, 103: e209608. PMID: 38991197, DOI: 10.1212/wnl.0000000000209608.Peer-Reviewed Original ResearchTrends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis
Hanin A, Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Wainwright M, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L. Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis. Epilepsia 2024, 65: e148-e155. PMID: 38837761, DOI: 10.1111/epi.18014.Peer-Reviewed Original ResearchNew-onset refractory status epilepticusSecond-line immunotherapyKetogenic dietStatus epilepticusDuration of status epilepticusRefractory status epilepticusStatus epilepticus onsetManagement of patientsEvolving treatment landscapeTreatment landscapeImmunotherapyConsensus recommendationsInterim analysisPatientsPatient outcomesAnakinraEpilepticusShort durationMedianORCIDietDaysTocilizumabIncreased useTreatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs
Au Y, Kananeh M, Rahangdale R, Moore T, Panza G, Gaspard N, Hirsch L, Fernandez A, Shah S. Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs. JAMA Neurology 2024, 81: 534-548. PMID: 38466294, DOI: 10.1001/jamaneurol.2024.0108.Peer-Reviewed Original ResearchAssociated with mortalityRefractory status epilepticusTreatment of refractory status epilepticusOutcome variablesPreferred Reporting ItemsAssociated with lower mortalityRisk of biasCompare outcome measuresPeer-reviewed studiesNon-English articlesStatus epilepticusBinary logistic regressionWeb of ScienceRSE etiologyReporting ItemsOutcome measuresStudy selectionPredictors of mortalitySystematic reviewLogistic regressionManual searchIntravenous anesthetic drugsRefractory status epilepticus treatmentTreatment goalsIndependent extractionComparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis
Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L, Hanin A. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis. Epilepsia 2024, 65: e87-e96. PMID: 38625055, DOI: 10.1111/epi.17988.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeRefractory status epilepticusMacrophage inflammatory protein-1 alphaOnset refractory status epilepticusStatus epilepticusCerebrospinal fluidFIRES patientsCerebrospinal fluid interleukin-6Magnetic resonance imaging findingsComparative analysis of patientsAnalysis of patientsChemokine ligand 2Presenting symptomsFebrile infectionsClinical featuresGastrointestinal prodromeImaging findingsInflammatory biomarkersAntiseizure medicationsInterleukin-6Epilepsy syndromesInterim analysisPatientsEpilepticusFever