Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsNicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2026
Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy
Leclercq V, Gaspard N. Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy. Clinical Neurophysiology Practice 2026 DOI: 10.1016/j.cnp.2026.04.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPost-stroke epilepsyStatus epilepticusAntiseizure medicationsQuantitative EEGDetection of nonconvulsive seizuresAssociated with adverse outcomesPeriodic EEG patternsLack of standardized strategiesOutcome-related dataAlpha-delta ratioRoutine clinical practiceRisk of post-stroke epilepsyEpileptiform abnormalitiesMulticenter trialPrognostic informationNonconvulsive seizuresAcute seizuresContinuous EEGAdverse outcomesEEG patternsImpaired consciousnessAcute phaseContinuous electroencephalographyFunctional recoveryRisk scoreExploring pathways leading to drug‐resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus
Hanin A, Marois C, Guillemaud M, Chavez M, Cosme L, Hayatou Z, Besnard A, Goudard G, Masson V, Cousyn L, Cheval M, Denis J, Alkouri R, Lamari F, Bisulli F, Eschbach K, Farias‐Moeller R, Gaspard N, Gerard E, Giovannini G, Gofton T, Gopaul M, Kellogg M, Meletti S, Muccioli L, Pasini E, Taraschenko O, Torcida N, Wainwright M, Yoo J, Wong N, Bonnefont‐Rousselot D, Demeret S, Hirsch L, Navarro V. Exploring pathways leading to drug‐resistant epilepsy for patients with cryptogenic new onset refractory status epilepticus. Epilepsia 2026 PMID: 41697646, DOI: 10.1002/epi.70146.Peer-Reviewed Original ResearchCryptogenic new-onset refractory status epilepticusNew-onset refractory status epilepticusOnset refractory status epilepticusElevated NfL levelsRefractory status epilepticusStatus epilepticusBrain injury biomarkersInjury biomarkersChronic phaseNfL levelsImmune disturbancesInnate cytokinesTLE-HSFunctional outcomesCerebrospinal fluidRisk of long-term disabilityMagnetic resonance imaging abnormalitiesNeuroaxonal injury biomarkerImmune-mediated encephalitisDrug-resistant epilepsyInnate immune activationPoor outcome predictionPoor functional outcomeTemporal lobe epilepsyProlonged SEProlonged postictal deficit: Uncomplicated Todd's palsy or nonconvulsive status epilepticus?
Kermorvant H, Di Caprio K, Damien C, Sedano N, Naeije G, Ligot N, Legros B, Gaspard N. Prolonged postictal deficit: Uncomplicated Todd's palsy or nonconvulsive status epilepticus? Epilepsia 2026 PMID: 41661101, DOI: 10.1002/epi.70140.Peer-Reviewed Original ResearchNonconvulsive status epilepticusRetrospective case-control studyNonconvulsive seizuresPostictal deficitsRetrospective case control study of patientsNCSE groupNonconvulsive status epilepticus patientsTodd's palsyCase-control study of patientsFocal to bilateral tonic-clonic seizuresBilateral tonic-clonic seizuresSporadic epileptiform dischargesPeriodic dischargesIctal-interictal continuumTertiary medical centerStudy of patientsTonic-clonic seizuresPostictal durationElectrographic featuresElectrographic characteristicsStatus epilepticusDifferential diagnosisEpileptiform dischargesEEG monitoringContinuous EEGResponse of early status epilepticus to benzodiazepines in chronic benzodiazepine users: A case–control study
Damien C, Lefebvre M, Torcida N, De Maeseneire C, Legros B, Depondt C, Gaspard N. Response of early status epilepticus to benzodiazepines in chronic benzodiazepine users: A case–control study. Epilepsia 2026 PMID: 41559945, DOI: 10.1002/epi.70111.Peer-Reviewed Original ResearchFirst-line treatmentChronic BZD useSecond-line treatmentStatus epilepticusEstablished SECase-control studyBZD useChronic useSE episodesAssociated with longer in-hospital stayLonger in-hospital stayRetrospective case-control studyEarly status epilepticusChronic use of benzodiazepinesAssociated with more frequent needIndependent risk factorChronic benzodiazepine usersIn-hospital stayUse of benzodiazepinesExposure to benzodiazepinesChronic BZD usersRisk of SEPharmacological toleranceChronic benzodiazepineTertiary center
2025
Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation
Moreau A, Su F, Ferlini L, Gaspard N, Pischiutta F, Zanier E, Creteur J, Annoni F, Taccone F. Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation. Intensive Care Medicine Experimental 2025, 13: 127. PMID: 41396233, PMCID: PMC12705496, DOI: 10.1186/s40635-025-00841-w.Peer-Reviewed Original ResearchReturn of spontaneous circulationExtracorporeal cardiopulmonary resuscitationConventional cardiopulmonary resuscitationNeuron-specific enolaseGlial fibrillary acidic proteinCardiopulmonary resuscitationIntracardiac injectionIntracardiac injection of potassium chlorideTreated with extracorporeal cardiopulmonary resuscitationCirculating BiomarkersAchievement of return of spontaneous circulationExtracorporeal membrane oxygenation supportIntracranial pressureEffect of therapeutic hypothermiaHypoxic-ischemic brain injuryVeno-arterial extracorporeal membrane oxygenation supportInjection of potassium chlorideLong-term neurological disabilityMembrane oxygenation supportControlled experimental modelImpact of hypothermiaCardiac arrest modelUntreated ventricular fibrillationCause of mortalityBrain tissueDisorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable
Bodien Y, Busl K, Chang C, Claassen J, Gaspard N, Gosseries O, Helbok R, Massimini M, Naccache L, Newcombe V, Robba C, Rohaut B, Suarez J, Turgeon A, Vespa P, Wahlster S, Taccone F, Citerio G. Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable. Intensive Care Medicine 2025, 52: 42-62. PMID: 41396553, PMCID: PMC12852174, DOI: 10.1007/s00134-025-08224-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEvidence-informed guidanceCritical care environmentClinical managementClinical management of patientsTrajectory of recoverySpectrum of clinical conditionsManagement of patientsCare environmentEmergency medicineFunctional neuroimagingDisorders of consciousnessDisorder of consciousness diagnosisMinimally conscious stateExpert cliniciansLevel of consciousnessBlood-based biomarkersClinical conditionsBrain injuryIntensive careClinical translationWakefulness syndromeConfoundingPatientsDiagnosisInterventionPrognostic significance of post-anoxic myoclonus: time for a reappraisal?
De Stefano P, Leitinger M, Quintard H, Trinka E, Gaspard N. Prognostic significance of post-anoxic myoclonus: time for a reappraisal? Resuscitation 2025, 217: 110896. PMID: 41237842, DOI: 10.1016/j.resuscitation.2025.110896.Commentaries, Editorials and LettersModified 2HELPS2B Score Predicts Failure to Wean From Anesthetics in Refractory and Super-Refractory Status Epilepticus
Matteo E, Damien C, Torcida Sedano N, Legros B, Gaspard N. Modified 2HELPS2B Score Predicts Failure to Wean From Anesthetics in Refractory and Super-Refractory Status Epilepticus. Neurology Clinical Practice 2025, 15: e200550. PMID: 41221027, PMCID: PMC12598878, DOI: 10.1212/cpj.0000000000200550.Peer-Reviewed Original ResearchSingle-center retrospective case-control studyStatus epilepticusElectrographic seizuresAssociated with successful weaningSuper-refractory status epilepticusAssociated with status epilepticusRefractory status epilepticusCritically ill patientsWeaning attemptsRefractory SESuccessful weaningIll patientsEEG variablesEpilepticusSuper-refractoryIntravenous anesthetic drugsPatientsSeizuresAnesthetic drugsScoresWeaningFailureRecurrenceTherapyAnestheticsFeatures, Outcome, and Treatment of Postanoxic Status Epilepticus
De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, Tromp S, Kornips B, Hilkman D, van Mook W, Hoedemaekers C, Annoni F, Legros B, Seeck M, Van Putten M, Gaspard N, investigators F. Features, Outcome, and Treatment of Postanoxic Status Epilepticus. Neurology 2025, 105: e214282. PMID: 40982774, PMCID: PMC12767611, DOI: 10.1212/wnl.0000000000214282.Commentaries, Editorials and LettersQuality of life over time after new onset refractory status epilepticus
Gruen M, Gopaul M, Jimenez A, Batra A, Blank L, Damien C, Day G, Eschbach K, Gerard E, Gofton T, Hantus S, Jette N, Jongeling A, Kang P, Kazazian K, Kellogg M, Kim M, Madani B, Morales M, Punia V, Steriade C, Struck A, Taraschenko O, Torcida N, Wainwright M, Yoo J, Gaspard N, Wong N, Hirsch L, Hanin A. Quality of life over time after new onset refractory status epilepticus. Epilepsia 2025, 67: 328-340. PMID: 40944696, PMCID: PMC12893261, DOI: 10.1111/epi.18635.Peer-Reviewed Original ResearchQuality of lifeAssociations with poor quality of lifePoor quality of lifeMeasures of fatigueQoL-ISocial support strategiesReference populationAssociated with more depressionQuality of life improvementMultidisciplinary support systemQuality of life impairmentNeuro-QoLPerceived stigmaMulticenter prospective studySocial healthSocial rolesSupport strategiesPediatric participantsIntensive care unit stayCognitive difficultiesCognitive impairmentGreater improvementAcute episodeT-scoreAdults