2024
Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation
Feys O, Schuind S, Sculier C, Rikir E, Legros B, Gaspard N, Wens V, De Tiège X. Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation. Epilepsia 2024 PMID: 39641210, DOI: 10.1111/epi.18183.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneCortico-corticalRefractory focal epilepsyElectrical stimulationBrain structuresEvoked responsesEffective connectivityEpileptogenic networksFocal epilepsyIntracranial EEGCortical/subcortical structuresComplex spatiotemporal dynamicsIntracranial recordingsStimulationMEG signalsLocation of electrodesMagnetoencephalographyVariability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence
Feys O, Wens V, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Variability of cortico‐cortical evoked potentials in the epileptogenic zone is related to seizure occurrence. Annals Of Clinical And Translational Neurology 2024, 11: 2645-2656. PMID: 39370736, PMCID: PMC11514933, DOI: 10.1002/acn3.52179.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneStereo-electroencephalography recordingsStereo-electroencephalographyEpileptogenic networksReceiver operating characteristic curveCortico-corticalOperating characteristics curveOccurrence of seizuresEpileptiform dischargesSeizure frequencyEpilepsy surgerySeizuresSeizure occurrenceCharacteristic curveSpearman correlationElectrical stimulationTime courseCCEPStimulationConnectivity modificationsSurgeryPatientsInfusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationComplications during and after ICU stay are associated with increased mortality after status epilepticus
Damien C, Yuan F, Legros B, Gaspard N. Complications during and after ICU stay are associated with increased mortality after status epilepticus. Clinical Neurology And Neurosurgery 2024, 246: 108554. PMID: 39278005, DOI: 10.1016/j.clineuro.2024.108554.Peer-Reviewed Original ResearchIntensive care unitStatus epilepticusIntensive care unit stayRisk factors of mortalityAssociated with increased mortalityMortality rateTertiary medical centerRetrospective cohort studyFactors of mortalityBurden of comorbiditiesIntensive care unit deathPost-ICU deathPrimary outcome measureIntensive care unit dischargeHigher mortality rateSE episodesICU complicationsNeurological emergencyCare unitRisk factorsOutcome measuresMedical CenterMortalityEpilepticusWardCommunication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K, Gofton T. Communication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry. Epilepsy & Behavior 2024, 160: 110023. PMID: 39241640, DOI: 10.1016/j.yebeh.2024.110023.Peer-Reviewed Original ResearchPalliative care servicesFamily RegistryCare servicesImprove overall carePrognostic conversationsAcute hospitalsOverall careEpidemiological informationConsensus definitionPhysician-patient-family relationshipRegistryNORSE/FIRESMinority of patientsPrognostic informationSatisfactionFamilySystematic effortRecovery processServicesCarePatientsHospitalPrevalenceQualityEpilepsy syndromesIn-hospital Management of Status Epilepticus: Does Uniformity Mean Quality?
Gaspard N. In-hospital Management of Status Epilepticus: Does Uniformity Mean Quality? Epilepsy Currents 2024, 24: 387-389. PMID: 39544726, PMCID: PMC11558722, DOI: 10.1177/15357597241261917.Peer-Reviewed Original ResearchEEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppressionQuantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome
van Putten M, Ruijter B, Horn J, van Rootselaar A, Tromp S, van Kranen-Mastenbroek V, Gaspard N, Hofmeijer J, Investigators F. Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome. Neurology 2024, 103: e209608. PMID: 38991197, DOI: 10.1212/wnl.0000000000209608.Peer-Reviewed Original ResearchTrends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis
Hanin A, Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Wainwright M, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L. Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis. Epilepsia 2024, 65: e148-e155. PMID: 38837761, DOI: 10.1111/epi.18014.Peer-Reviewed Original ResearchNew-onset refractory status epilepticusSecond-line immunotherapyKetogenic dietStatus epilepticusDuration of status epilepticusRefractory status epilepticusStatus epilepticus onsetManagement of patientsEvolving treatment landscapeTreatment landscapeImmunotherapyConsensus recommendationsInterim analysisPatientsPatient outcomesAnakinraEpilepticusShort durationMedianORCIDietDaysTocilizumabIncreased useTreatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs
Au Y, Kananeh M, Rahangdale R, Moore T, Panza G, Gaspard N, Hirsch L, Fernandez A, Shah S. Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs. JAMA Neurology 2024, 81: 534-548. PMID: 38466294, DOI: 10.1001/jamaneurol.2024.0108.Peer-Reviewed Original ResearchAssociated with mortalityRefractory status epilepticusTreatment of refractory status epilepticusOutcome variablesPreferred Reporting ItemsAssociated with lower mortalityRisk of biasCompare outcome measuresPeer-reviewed studiesNon-English articlesStatus epilepticusBinary logistic regressionWeb of ScienceRSE etiologyReporting ItemsOutcome measuresStudy selectionPredictors of mortalitySystematic reviewLogistic regressionManual searchIntravenous anesthetic drugsRefractory status epilepticus treatmentTreatment goalsIndependent extractionComparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis
Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L, Hanin A. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis. Epilepsia 2024, 65: e87-e96. PMID: 38625055, DOI: 10.1111/epi.17988.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeRefractory status epilepticusMacrophage inflammatory protein-1 alphaOnset refractory status epilepticusStatus epilepticusCerebrospinal fluidFIRES patientsCerebrospinal fluid interleukin-6Magnetic resonance imaging findingsComparative analysis of patientsAnalysis of patientsChemokine ligand 2Presenting symptomsFebrile infectionsClinical featuresGastrointestinal prodromeImaging findingsInflammatory biomarkersAntiseizure medicationsInterleukin-6Epilepsy syndromesInterim analysisPatientsEpilepticusFeverMachine Learning-informed Subtyping of Generalized Periodic Discharges in Cardiac Arrest (S23.006)
Karukonda V, Aghaeeaval M, Kandhare P, Zheng W, Jing J, Ghassemi M, Lee J, Herman S, Sivaraju A, Gaspard N, Hofmeijer J, van Putten M, Westover M, Amorim E. Machine Learning-informed Subtyping of Generalized Periodic Discharges in Cardiac Arrest (S23.006). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204918.Peer-Reviewed Original ResearchClinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE)
Costello D, Matthews E, Aurangzeb S, Doran E, Stack J, Wesselingh R, Dugan P, Choi H, Depondt C, Devinsky O, Doherty C, Kwan P, Monif M, O'Brien T, Sen A, Gaspard N. Clinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE). Epilepsia 2024, 65: 1581-1588. PMID: 38498313, DOI: 10.1111/epi.17950.Peer-Reviewed Original ResearchActive epilepsyClinical outcomesMental health outcomesMonths post-dischargeMonths of dischargeTreatment strategiesAcute phaseHealth outcomesLonger-term outcomesGlobal disabilityPost-dischargeMinority of patientsTertiary care centerTailored treatment strategiesNature of treatmentSevere clinical syndromeCare centerDeterminants of outcomePsychiatric comorbiditiesWell-characterized casesFunctional outcomesSurvivorsInvestigated patientsFollow-upSpecialist centersDouble, Double Toil and Trouble: Recurrent Episodes of Status Epilepticus Are Associated With Increasingly Worse Outcomes
Gaspard N. Double, Double Toil and Trouble: Recurrent Episodes of Status Epilepticus Are Associated With Increasingly Worse Outcomes. Epilepsy Currents 2024, 24: 316-317. PMID: 39508023, PMCID: PMC11536410, DOI: 10.1177/15357597231223587.Peer-Reviewed Original ResearchCombined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value
Yuan F, Damien C, Schuind S, Salvagno M, Taccone F, Legros B, Gaspard N. Combined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value. European Journal Of Neurology 2024, 31: e16208. PMID: 38270448, PMCID: PMC11235592, DOI: 10.1111/ene.16208.Peer-Reviewed Original ResearchIctal-interictal continuumAcute brain injuryAcute brain injury patientsIctal-interictal continuum patternsDepth electroencephalographyRate of poor outcomeSporadic epileptiform dischargesElectrophysiological activityIctal rhythmic dischargesSpike-and-waveBrain injuryAbnormal electrophysiological activityElectrographic seizuresEpileptiform dischargesPoor outcomeRhythmic dischargesPatientsElectroencephalographic monitoringConcomitant seizuresScalp EEGPeriodic dischargesSeizuresNeuromonitoringABI patientsInjurySustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE)
Damien C, Leitinger M, Kellinghaus C, Strzelczyk A, De Stefano P, Beier C, Sutter R, Kämppi L, Strbian D, Taubøll E, Rosenow F, Helbok R, Rüegg S, Damian M, Trinka E, Gaspard N. Sustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE). BMC Neurology 2024, 24: 19. PMID: 38178048, PMCID: PMC10765797, DOI: 10.1186/s12883-023-03505-y.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusRefractory status epilepticusStatus epilepticusEuropean AcademyCommon neurological emergencyMulticenter prospective registryLarge randomized trialsProspective multicenter observational registryMulticenter observational registryDeep general anesthesiaDifferent patient groupsDistinct EEG patternsConvulsive SEMulticenter registryObservational registryProspective registryConsecutive adultsNeurological emergencyRandomized trialsRefractory SEGeneral anesthesiaPatient groupTreatment modalitiesClinical trialsFunctional decline
2023
Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG
Feys O, Wens V, Rovai A, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG. Clinical Neurophysiology 2023, 158: 59-68. PMID: 38183887, DOI: 10.1016/j.clinph.2023.12.013.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneRefractory focal epilepsyEffective connectivityEffective connectivity changesResection limitsEpileptogenic networksFocal epilepsyAbnormal responseCortico-subcorticoCortical levelElectrical stimulationStereo-EEGPatientsDepth electrodesConnectivity changesStereoelectroencephalographyAnalysis of varianceCharacteristic curveOccurrence of spikesCCEPsStimulationHigh-frequency oscillationsAssociationResponseStatus epilepticus in the ICU
Rossetti A, Claassen J, Gaspard N. Status epilepticus in the ICU. Intensive Care Medicine 2023, 50: 1-16. PMID: 38117319, DOI: 10.1007/s00134-023-07263-w.Peer-Reviewed Original ResearchSuper-refractory status epilepticusIntensive care unitStatus epilepticusAntiseizure medicationsUnderlying causeContinuous video electroencephalographyAcute brain injuryConvulsive status epilepticusNon-pharmacologic approachesNonconvulsive status epilepticusShort-term mortalityCommon medical emergencyAutoimmune encephalitisMedical comorbiditiesInitial managementSignificant morbidityCare unitCardiac arrestResponsive casesVideo electroencephalographyContinuous infusionBrain injuryRapid administrationSevere casesMedical emergencyOn‐Scalp Magnetoencephalography Based On Optically Pumped Magnetometers Can Detect Mesial Temporal Lobe Epileptiform Discharges
Feys O, Ferez M, Corvilain P, Schuind S, Rikir E, Legros B, Gaspard N, Holmes N, Brookes M, Wens V, De Tiège X. On‐Scalp Magnetoencephalography Based On Optically Pumped Magnetometers Can Detect Mesial Temporal Lobe Epileptiform Discharges. Annals Of Neurology 2023, 95: 620-622. PMID: 38050959, DOI: 10.1002/ana.26844.Peer-Reviewed Original ResearchPredicting Neurological Recovery from Coma After Cardiac Arrest: The George B. Moody PhysioNet Challenge 2023
Reyna M, Amorim E, Sameni R, Weigle J, Elola A, Rad A, Seyedi S, Kwon H, Zheng W, Ghassemi M, van Putten M, Hofmeijer J, Gaspard N, Sivaraju A, Herman S, Lee J, Westover M, Clifford G. Predicting Neurological Recovery from Coma After Cardiac Arrest: The George B. Moody PhysioNet Challenge 2023. 2016 Computing In Cardiology Conference (CinC) 2023, 50: 1-4. DOI: 10.22489/cinc.2023.019.Peer-Reviewed Original Research