Manju Prasad, MBBS, MD
Professor Emeritus of PathologyCards
Additional Titles
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology
Director, Endocrine, Head and Neck Pathology, Pathology
Contact Info
About
Titles
Professor Emeritus of Pathology
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology; Director, Endocrine, Head and Neck Pathology, Pathology
Biography
Dr. Manju Prasad, Professor of Pathology at Yale School of Medicine, is an oncologic surgical pathologist with a lifelong interest in cancers of the head and neck, and endocrine organs including thyroid, parathyroid and adrenal glands. After obtaining MBBS and MD in Pathology from the Institute of Medical Sciences, Banaras Hindu University, she became a Senior Demonstrator in the department of pathology at the All India Institute of Medical Sciences, and later Assistant Professor at the Lady Harding Medical College in New Delhi, India. Dr. Prasad came to the USA in 1994 and underwent further training at the New York-Presbyterian Hospital of Cornell University and at Memorial Sloan Kettering Cancer Center in New York City. Dr. Prasad’s research includes head and neck melanomas arising in UV-light-protected sites, e.g., oral and nasal mucosa, HPV-associated cancers of the head and neck, and genotype-phenotype correlation in thyroid, parathyroid, and adrenal tumors. She serves on the editorial board of leading pathology journals, and since 2005 has contributed several chapters to the third, fourth and fifth editions of the World Health Organization’s Blue Book series on Classification of Tumors. Dr. Prasad served as treasurer, secretary, vice-president and President of the North American Society of Head and Neck Pathologists and continues to be a member of the executive board of the society. She is a member of the European Society of Pathology and its working group on Head and Neck Pathology. She has been an invited speaker, moderator and chair of scientific sessions and a judge of presentations in her field of expertise at many national and international meetings. Dr. Prasad is deeply committed to patient care through teaching young physicians-in-training and extending her expertise to oncologists to help with treatment plans individualized to each patient. She was recruited to Yale to start a new Endocrine, Head & Neck subspecialty pathology program and a fellowship. Dr. Prasad has received multiple awards throughout her career including Best Teacher award, Hubert Wolfe award for most outstanding paper in endocrine pathology by her trainee, and the Yale Cancer Center award for Clinical Excellence.
Appointments
Pathology
EmeritusPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Memorial Sloan Kettering Cancer Center (2000)
- Fellow`
- Memorial Sloan Kettering Cancer Center (1999)
- Resident
- New York Presbyterian Hospital (1998)
- MD
- Institute of Medical Sciences Varanasi (1984)
- MBBS
- Institute of Medical Sciences Varanasi (1981)
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1998
Research
Overview
Medical Research Interests
ORCID
0000-0002-4507-2601
Research at a Glance
Yale Co-Authors
Publications Timeline
Andrea Barbieri, MD
Benjamin L. Judson, MD, MBA
Catherine Anne Dinauer, MD
Adebowale Adeniran, MD
Guoping Cai, MD, MS
Barbara Burtness, MD
Publications
2025
FDG-PET intensity normalization improves radiomics- based survival prediction in oropharyngeal cancer patients: a comparison of the SUV with alternative normalization techniques.
Payabvash S, Sharaf K, Zeevi T, Gross M, Mahajan A, Kann B, Judson B, Schreier A, Krenn J, Prasad M, Burtness B, Aboian M, Canis M, Baumeister P, Reichel C, Haider S. FDG-PET intensity normalization improves radiomics- based survival prediction in oropharyngeal cancer patients: a comparison of the SUV with alternative normalization techniques. American Journal Of Neuroradiology 2025, ajnr.a8836. PMID: 40379456, DOI: 10.3174/ajnr.a8836.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaStandardized uptake valueSquamous cell carcinomaFDG-PETRadiomic featuresPET featuresOncological outcomesLentiform nucleusCell carcinomaUptake valuePrognostic value of radiomics featuresC-indexOropharyngeal squamous cell carcinoma patientsValue of radiomic featuresProgression-free survivalOropharyngeal cancer patientsUnivariate Cox regression modelPredicting oncological outcomesRandom survival forestArea under the curveHarrell's concordance indexIndividual radiomics featuresStandardized uptake ratioHarrell's C-indexCox regression models315 Clinicopathologic Characteristics of Thyroid Nodules with THADA-IGF2BP3 Fusion Identified on Fine Needle Aspiration
Bernhisel A, Sun T, Prasad M, Ladenheim A, Cai G, Adeniran A. 315 Clinicopathologic Characteristics of Thyroid Nodules with THADA-IGF2BP3 Fusion Identified on Fine Needle Aspiration. Laboratory Investigation 2025, 105: 102542. DOI: 10.1016/j.labinv.2024.102542.Peer-Reviewed Original Research411 Correlation of ACR-TI-RADS, Cytology, Histology, and Molecular studies
Yu S, Wang M, Langdon J, Sinard J, Cai G, Prasad M, Adeniran A. 411 Correlation of ACR-TI-RADS, Cytology, Histology, and Molecular studies. Laboratory Investigation 2025, 105: 102638. DOI: 10.1016/j.labinv.2024.102638.Peer-Reviewed Original Research542 Clinicopathologic Features of Thyroid Nodules with BRAF non-V600E Mutations
Verma A, Cedeño E, Abi-Raad R, Ladenheim A, Prasad M. 542 Clinicopathologic Features of Thyroid Nodules with BRAF non-V600E Mutations. Laboratory Investigation 2025, 105: 102772. DOI: 10.1016/j.labinv.2024.102772.Peer-Reviewed Original Research
2024
EIF1AX mutation in thyroid nodules: a histopathologic analysis of 56 cases in the context of institutional practices
Abi-Raad R, Xu B, Gilani S, Ghossein R, Prasad M. EIF1AX mutation in thyroid nodules: a histopathologic analysis of 56 cases in the context of institutional practices. Virchows Archiv 2024, 485: 859-867. PMID: 39225726, PMCID: PMC11912518, DOI: 10.1007/s00428-024-03914-5.Peer-Reviewed Original ResearchConceptsFollicular nodular diseaseAnaplastic thyroid carcinomaPapillary thyroid carcinomaEIF1AX mutationsBenign thyroid nodulesThyroid carcinomaThyroid nodulesOncocytic adenomasMolecular alterationsGenetic abnormalitiesNon-invasive follicular thyroid neoplasmPapillary-like nuclear featuresAssociated with malignant tumorsWHO 5th EditionCancer referral centerFollicular thyroid neoplasmTertiary care hospitalOncocytic carcinomaThyroid neoplasmsReferral centerNodular diseasePathological diagnosisCancer Genome AtlasMalignant tumorsEIF1AXSeven years of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Rate of Acceptance and Variation of Diagnostic Approaches Across Different Continents
Williams M, Liu Z, Rossi E, Agarwal S, Ryška A, Al Ghuzlan A, Bychkov A, Baloch Z, Chernock R, Chiosea S, Cipriani N, Erkilic S, Fridman M, Hang J, Harahap A, Jung C, Kakudo K, Khalil M, Khanafshar E, Kumarasinghe P, Lloyd R, Nguyen T, Ocal I, Prasad M, Pusztaszeri M, Rana C, Sadow P, Sajed D, Seethala R, Tallini G, Vuong H, Yegen G, LiVolsi V, Nikiforov Y. Seven years of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Rate of Acceptance and Variation of Diagnostic Approaches Across Different Continents. The Journal Of Clinical Endocrinology & Metabolism 2024, 110: 166-175. PMID: 38874075, DOI: 10.1210/clinem/dgae354.Peer-Reviewed Original ResearchCitationsConceptsPapillary-like nuclear featuresFollicular thyroid neoplasmPapillary thyroid carcinomaNuclear scoreThyroid neoplasmsWhole slide imagesEncapsulated follicular variant of papillary thyroid carcinomaFollicular variant of papillary thyroid carcinomaNoninvasive encapsulated follicular variant of papillary thyroid carcinomaVariant of papillary thyroid carcinomaNuclear featuresNoninvasive follicular thyroid neoplasmNon-invasive follicular thyroid neoplasmIncidence of NIFTPAdoption rateSlide imagesDiagnosing NIFTPNIFTP diagnosisThyroid carcinomaEndocrine pathologistsNIFTPDiagnosing lesionsNorth AmericaDiagnostic approachPractice patternsSingle-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue
Venkat A, Carlino M, Lawton B, Prasad M, Amodio M, Gibson C, Zeiss C, Youlten S, Krishnaswamy S, Krause D. Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue. Genome Research 2024, 34: 837-850. PMID: 38977309, PMCID: PMC11293540, DOI: 10.1101/gr.278215.123.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell statesMitochondrial transcript abundanceParathyroid glandsHuman parathyroidCell-cell communication analysisRNA expression analysisSingle-cell analysisTranscriptional dynamicsTranscript abundanceExpression dynamicsRNA transcriptomeEpithelial cell statesCell abundanceExpression analysisPseudotime analysisImpact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers
Haider S, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann B, Judson B, Prasad M, Burtness B, Aboian M, Canis M, Reichel C, Baumeister P, Payabvash S. Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266637. PMID: 38514087, PMCID: PMC11927063, DOI: 10.2967/jnumed.123.266637.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOropharyngeal squamous cell carcinomaSquamous cell carcinomaHuman papillomavirusRadiomic featuresIntraclass correlation coefficientCell carcinomaLentiform nucleusHuman papillomavirus statusReceiver-operating-characteristic analysisReceiver-operating-characteristic curvePET radiomic featuresUnivariate logistic regressionF-FDGPrimary tumorTraining cohortValidation cohortRadiomic biomarkersUnivariate analysisInterindividual comparabilityPredictive valueDegree of reproducibilityMedian areaRadiomic markersLogistic regressionAUCMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchCitationsConceptsFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluation
2023
Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry
Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G, Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. Cytopathology 2023, 34: 219-224. PMID: 36825365, DOI: 10.1111/cyt.13222.Peer-Reviewed Original ResearchCitationsAltmetric
News & Links
Media
- Nodules of tumor cells infiltrating thyroid tissue and blood vessels
- The patient was an 80-year-old man who was coughing blood. The thyroid tumor was massive and had eroded through his trachea leading to coughing and bleeding. The tumor is a tall cell variant of papillary thyroid carcinoma.
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Brady Memorial Laboratory
310 Cedar Street, Wing Lauder Hall, Fl 2nd, Ste LH-222
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203.785.2788