Lorenzo Sewanan
Research
Publications
Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regressionEvolving Strategies for Management of Obstructive Hypertrophic Cardiomyopathy
Liang L, Lumish H, Sewanan L, Shimada Y, Maurer M, Weiner S, Clerkin K. Evolving Strategies for Management of Obstructive Hypertrophic Cardiomyopathy. Journal Of Cardiac Failure 2024 PMID: 38777216, DOI: 10.1016/j.cardfail.2024.04.024.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyObstructive HCMLeft ventricular outflow tract obstructionVentricular outflow tract obstructionImproved cardiac energeticsSeptal reduction therapyOutflow tract obstructionTreatment of hypertrophic cardiomyopathyRandomized clinical trialsReal-world populationSpecific therapiesPatient selectionHeterogeneous diseaseReduction therapyClinical trialsCardiac energeticsMavacamtenExercise capacityActin-myosin interactionPatientsMyosin modulatorsCardiomyopathyLong-term dataTherapy
Links & Media
News
- July 27, 2022
Uncovering New Approaches to a Common Inherited Heart Disorder
- May 24, 2021
CONGRATULATIONS to the 2021 MD-PhD Program Graduates and Graduation Prize Recipients
- February 04, 2020
Yale researchers find that ubiquitous protein plays lead role in cell survival
- October 20, 2019
$2M Federal Funding for Stem Cell-Based Therapy