Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury
Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, Blesch A. Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia 2017, 60: 167-180. PMID: 28735026, DOI: 10.1016/j.actbio.2017.07.024.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHost spinal cordSpinal cord injurySpinal cordLesion siteSchwann cellsBDNF expressionCord injuryNeurotrophic factorAxonal regenerationBDNF deliveryExpression of BDNFGraft/host interfaceSpinal cord lesion siteAdult mammalian central nervous systemHost/graft interfaceSpinal cord transectionMammalian central nervous systemRat spinal cordCentral nervous systemCaudal spinal cordCaudal injectionHemisection lesionCord transectionCell transplantation