Joseph Paul Antonios, MD, PhD
Hospital ResidentCards
About
Research
Publications
2026
Safety of endovascular shunting for normal pressure hydrocephalus from a prospective, multicenter, single-arm study
Lylyk P, Matouk C, Hanel R, Reavey-Cantwell J, Riina H, Altschul D, Siddiqui A, Fraser J, Ebersole K, Bhalla T, Bender M, Ogilvy C, Taussky P, Baker A, Jayaraman M, Lylyk I, Perez N, Bleise C, Scrivano E, Lylyk P, Nowicki K, Koo A, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. Safety of endovascular shunting for normal pressure hydrocephalus from a prospective, multicenter, single-arm study. Journal Of NeuroInterventional Surgery 2026, jnis-2025-024702. PMID: 41734937, DOI: 10.1136/jnis-2025-024702.Peer-Reviewed Original ResearchSerious adverse eventsProcedure-related serious adverse eventsNormal pressure hydrocephalusEndovascular shuntRate of serious adverse eventsDevice-related serious adverse eventsCerebrospinal fluidPressure hydrocephalusTreatment of normal pressure hydrocephalusSigmoid sinus thrombosisInternal jugular veinSingle-arm studyNormal pressure hydrocephalus symptomsMatched-pair analysisFemoral artery pseudoaneurysmSingle-arm trialStandard of careImplant placementRandomized Controlled TrialsShunt placementUrinary symptomsClinical responseShunt surgerySinus thrombosisPrimary endpoint
2025
Immune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping
Antonios J, Gultekin B, Theriault B, Yalcin K, Miyagishima D, Adenu-Mensah N, Sujijantarat N, Koo A, Haynes J, Cedeno P, Johnson M, Hebert R, Matouk C, Barak T, Gunel M. Immune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping. Neurology 2025, 105: e214185. PMID: 40997288, DOI: 10.1212/wnl.0000000000214185.Peer-Reviewed Original ResearchConceptsIntracranial aneurysmsEndoluminal biopsyImmune landscapeImmune characterizationSubarachnoid hemorrhageGroup 1Characterization of intracranial aneurysmsDilation of cerebral arteriesPathological dilatationProspective observational cohort studyUpregulation of CD38Neutrophil-dominated inflammationImmune regulatory mechanismsAssociated with aneurysm growthYale-New Haven HospitalPathological dilatations of cerebral arteriesFisher's exact testObservational cohort studyImmune-based biomarkersUnruptured intracranial aneurysmsNo significant associationImmune signaturesImmunomodulatory therapyHLA-DRNeutrophil predominanceClot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review
Kosyakovsky J, Rossitto C, Antonios J, Renedo D, Stapleton C, Sansing L, Navaratnam D, Giles J, Patel A, Matouk C, Sujijantarat N. Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review. Journal Of Clinical Medicine 2025, 14: 6203. PMID: 40943965, PMCID: PMC12429028, DOI: 10.3390/jcm14176203.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLarge-artery atherosclerosisAcute ischemic strokeStroke etiologyMechanical thrombectomySecondary stroke preventionStandard of careCryptogenic subtypesClot pathologyClinical levelStroke preventionMultiple comorbiditiesHistological featuresStrokeMolecular analysisIschemic strokeClinical objectivesMultiomics sequencingClinical diagnosisEtiologyClearer understandingCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokeLumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series: Corrigendum
Sujijantarat N, Koo A, Elsamadicy A, Antonios J, Renedo D, Haynes J, Fathima B, Theriault B, Chavez M, Amllay A, Nowicki K, Kanzler M, Jiang J, Hebert R, DiLuna M, Matouk C. Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series: Corrigendum. Neurosurgery Practice 2025, 6: e000147. PMID: 41163661, PMCID: PMC12560692, DOI: 10.1227/neuprac.0000000000000147.Commentaries, Editorials and LetterseShunt system: a technical video.
Koo A, Lylyk I, Antonios J, Lylyk P, Perez N, Bleise C, Hebert R, Lylyk P, Matouk C. eShunt system: a technical video. Journal Of NeuroInterventional Surgery 2025, 17: 792. PMID: 40379475, DOI: 10.1136/jnis-2025-023365.Peer-Reviewed Original ResearchVariations in Academic Neurosurgery Physician Compensation in the United States
Koo A, Futela D, Stogniy S, Renedo D, Sujijantarat N, Elsamadicy A, Amllay A, Kanzler M, Antonios J, Hebert R, Malhotra A, Matouk C. Variations in Academic Neurosurgery Physician Compensation in the United States. World Neurosurgery 2025, 198: 124007. PMID: 40288524, DOI: 10.1016/j.wneu.2025.124007.Peer-Reviewed Original ResearchConceptsPhysician compensationU.S. medical schoolsFull-time academic facultyInvestigate recent trendsSalary survey dataSecondary analysisMedical schoolsNeurosurgery facultyUnited StatesFaculty membersSalary compensationRace/ethnicityAcademic facultyAnnual compensationCompensation dataStudy periodNeurosurgery DepartmentFemale counterpartsRecent trendsSalary inequitiesMedian compensationSurvey dataGeographic regionsAssociationThe Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients
Antonios J, Adenu-Mensah N, Theriault B, Millares-Chavez M, Huttner A, Aboian M, Chiang V. The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients. Clinical And Translational Neuroscience 2025, 9: 10. DOI: 10.3390/ctn9010010.Peer-Reviewed Original ResearchCentral vein signRadiation necrosisTumor progressionDiagnosis of radiation necrosisDifferentiate RNCerebral radiation necrosisIntracranial metastatic diseaseCancer therapy responseMetastatic cancer patientsNon-invasive markerMetastatic diseaseSurgical biopsyTherapy responsePredictive markerPatient cohortPrimary treatmentRadiological toolsCancer patientsRadiological imagingTreatment decisionsPerivascular spacesPatientsTreatmentNecrosisMarkersChronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex
Hauptman J, Antonios J, Mathern G, Levine M, Cepeda C. Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex. Cells 2025, 14: 79. PMID: 39851507, PMCID: PMC11764219, DOI: 10.3390/cells14020079.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsMice treated with rapamycinGABA releasePTEN deletionWhole-cell patch-clamp recordingsMiniature inhibitory postsynaptic currentsEx vivo slicesNeuronal somatic sizeReduced neuronal firingInhibitory postsynaptic currentsChronic rapamycin treatmentPatch-clamp recordingsIncreased input resistanceInhibitory synaptic inputsDevelopmental brain disordersRapamycin treatmentIncreased membrane capacitanceConditional mouse modelChronic treatmentPostsynaptic currentsClamp recordingsNaive miceSynaptic excitationBrain disordersControl mice
2024
Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series
Sujijantarat N, Koo A, Elsamadicy A, Antonios J, Renedo D, Haynes J, Fathima B, Theriault B, Chavez M, Amllay A, Nowicki K, Kanzler M, Jiang J, Shekar A, Hebert R, DiLuna M, Matouk C. Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series. Neurosurgery Practice 2024, 5: e00113. PMID: 39959535, PMCID: PMC11810006, DOI: 10.1227/neuprac.0000000000000113.Peer-Reviewed Original ResearchIdiopathic intracranial hypertensionIntracranial hypertensionTreatment of idiopathic intracranial hypertensionManagement of idiopathic intracranial hypertensionMedical records of patientsAssessment of long-term outcomesHigh-pressure headachesMedian operative timeDifficult-to-manage patientsLow-pressure headacheCerebrospinal fluid shuntsElectronic medical records of patientsRecords of patientsFollow-up visitLong-term outcomesLumbar shuntDifficult-to-manage casesIntraoperative complicationsShunt revisionImprove headacheCase seriesEarly outcomesSurgical techniqueNeurosurgical managementOperative time
News
News
- September 29, 2025Source: Neurology
Immune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping
- February 07, 2023
Daniela Renedo, MD Wins American Heart Association Stroke Basic Science Award
- May 28, 2021
Recent Research Sheds Light on Link Between Meningiomas and Seizures