Grass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapy
Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW. Grass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapy. Clinical & Experimental Allergy 2014, 44: 986-998. PMID: 24708411, PMCID: PMC4069242, DOI: 10.1111/cea.12324.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAllergensAmino Acid SequenceAntigens, PlantBasophilsCD4-Positive T-LymphocytesCross ReactionsCytokinesDesensitization, ImmunologicEpitopes, T-LymphocyteHLA AntigensHumansImmunoglobulin ELymphocyte ActivationPeptidesPoaceaePollenT-Cell Antigen Receptor SpecificityT-Lymphocyte SubsetsConceptsT cell epitopesReactive T cellsCross-reactive T-cell epitopesT cell levelsT cellsAllergic subjectsIntracellular cytokine staining assaysCross-reactive profilesEx vivo stainingAllergen-specific immunotherapySpecific T cellsGrass pollen allergensPhl p 1Staining assaysPhl pTetramer stainingImmunotherapy strategiesAllergic responsesComparison of frequencyAntigenic epitopesComparable frequencyVivo stainingEpitopesImmunotherapyAllergens