2022
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Perry J, Shallberg L, Clark J, Gullicksrud J, DeLong J, Douglas B, Hart A, Lanzar Z, O’Dea K, Konradt C, Park J, Kuchroo J, Grubaugh D, Zaretsky A, Brodsky I, Malefyt R, Christian D, Sharpe A, Hunter C. PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 2022, 23: 743-756. PMID: 35437326, PMCID: PMC9106844, DOI: 10.1038/s41590-022-01170-w.Peer-Reviewed Original ResearchConceptsPD-1ETreg cellsPD-L1Interleukin-10T cellsCell expressionInhibitory receptor PD-1Regulatory T cell populationDevelopment of immunopathologyTreg cell populationRegulatory T cellsEffector T cellsPD-1 interactionReceptor PD-1T cell populationsCell populationsMyeloid cell expressionT cell receptor activationLineage-specific deletionTreg cellsEffector phenotypeInfected miceCell receptor activationInflammatory processEarly interferon
2016
Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells
Yang Y, DeLong J, Zhang K. Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells. Single Cell Biology 2016, 5: 1-2. DOI: 10.4172/2168-9431.1000146.Peer-Reviewed Original ResearchPD-L1Immune cellsAnti-PD-1 antibodyTumor microenvironmentTumor cellsPD-L1 expressionT effector cellsProliferation of CD8Receptor PD-1Immune checkpoint proteinsB7-H1PD-1Effector cellsCancer immunotherapyImmune responseSmall molecule inhibitorsInhibitory signalsClinical drugsMolecule inhibitorsCellsMicroenvironmentCD8ImmunotherapyCheckpoint proteinsCD274