Jeans Miguel Santana, MD
he/him/his
Assistant Professor of AnesthesiologyCards
About
Research
Publications
2022
Mechanical Circulatory Support Options in Patients With Aortic Valve Pathology
Santana J, Dalia A, Newton M, Pisano D, Eapen S, Kawabori M, Ortoleva J. Mechanical Circulatory Support Options in Patients With Aortic Valve Pathology. Journal Of Cardiothoracic And Vascular Anesthesia 2022, 36: 3318-3326. PMID: 35545462, DOI: 10.1053/j.jvca.2022.04.010.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportMechanical circulatory support optionsMCS typeVenoarterial extracorporeal membrane oxygenationIntra-aortic balloon pumpSymptomatic coronary artery diseaseVentricular arrhythmia burdenAortic valve pathologyExtracorporeal membrane oxygenationHigh-risk patientsMCS optionsCoronary artery diseaseIncreased blood pressurePeriprocedural hemodynamic stabilityPercutaneous left ventricular assist deviceInotropic supportAortic insufficiencyArrhythmia burdenAortic stenosisValve pathologyMembrane oxygenationLeft ventricular assist deviceValvular pathologyAV pathologyBalloon pumpIntraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion
Santana J, Rosell F, Dave B, Manafi A. Intraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion. Annals Of Cardiac Anaesthesia 2022, 25: 77-80. PMID: 35075025, PMCID: PMC8865348, DOI: 10.4103/aca.aca_192_20.Peer-Reviewed Original Research
2021
Prothrombin complex concentrates in cardiac surgery: where are we?
Santana J, Brovman E. Prothrombin complex concentrates in cardiac surgery: where are we? Current Opinion In Anaesthesiology 2021, 35: 36-41. PMID: 34669612, DOI: 10.1097/aco.0000000000001074.Peer-Reviewed Original ResearchConceptsProthrombin complex concentrateFresh frozen plasmaCardiac surgeryRBC transfusionRed blood cellsRate of RBC transfusionProthrombin complex concentrate administrationReducing RBC transfusionsConcentrations of coagulation factorsOff-label useAssociated with reduced ratesFrozen plasmaSafety profileProthrombin complexSurgeryCoagulation factorsHemostatic agentsTransfusionComplex concentrateBlood cellsMeta-analysisCochrane reviewAdministration timeProthrombinShort acquisition
2019
Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency
Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A. Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 754-764. PMID: 30786746, PMCID: PMC6436985, DOI: 10.1161/atvbaha.119.312417.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalArteriovenous Shunt, SurgicalCaveolaeCaveolin 1Cells, CulturedDrug Evaluation, PreclinicalHemorheologyHumansLungMaleMiceMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIPeptide FragmentsReceptor, EphB4Signal TransductionVascular RemodelingVena Cava, InferiorConceptsCav-1 KO miceAVF maturationWT miceAVF patencyEph-B4KO miceCav-1 functionCav-1Mouse aortocaval fistula modelEphrin-B2/FcArteriovenous fistula patencyAortocaval fistula modelCaveolin-1 SignalingFistula environmentCav-1 mRNAFistula patencyHET miceVenous adaptationEndothelial cell membraneENOS activityFistula modelRC miceControl veinsWall thickeningMice
2018
CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues
Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. Journal Of Biological Chemistry 2018, 293: 9126-9136. PMID: 29588368, PMCID: PMC5995495, DOI: 10.1074/jbc.ra117.000773.Peer-Reviewed Original ResearchConceptsCircadian locomotor output cycles kaputCLOCK phosphorylationCircadian gene expressionPhosphorylation sitesGene expressionNovel phosphorylation sitesClock-controlled genesCRISPR/Cas9 technologyNovel Akt substrateE-box elementsCore circadian genesAkt substrateTranscription factorsE-boxCentral circadian rhythmNuclear localizationNegative regulatorCas9 technologyNuclear accumulationCircadian genesInsulin-sensitive tissuesNuclear translocationPhosphorylationExpression levelsSer-845High-density lipoprotein carbamylation and dysfunction in vascular disease.
Santana J, Brown C. High-density lipoprotein carbamylation and dysfunction in vascular disease. Frontiers In Bioscience-Landmark 2018, 23: 2227-2234. PMID: 29772557, DOI: 10.2741/4701.Peer-Reviewed Original ResearchConceptsIrreversible post-translational modification of proteinsPost-translational modification of proteinsIrreversible post-translational modificationModification of proteinsChronic kidney diseaseAtherosclerotic cardiovascular diseaseComplex macromoleculesSusceptible to modificationCarbamylationNon-enzymaticAnti-atherogenic propertiesHDL functionCardiovascular diseaseAnti-atherogenicProgression of atherosclerotic cardiovascular diseaseHigh-density lipoprotein (HDLLife spanLipoprotein (HDLProteomicsAnti-thrombotic effects
2017
Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency
Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Scientific Reports 2017, 7: 15386. PMID: 29133876, PMCID: PMC5684317, DOI: 10.1038/s41598-017-13071-2.Peer-Reviewed Original ResearchConceptsEphrin-B2/FcVenous remodelingAVF maturationFistula patencyEph-B4Knockout miceMouse aortocaval fistula modelAkt1 knockout miceArteriovenous fistula patencyAortocaval fistula modelArteriovenous fistula maturationFistula environmentFistula useFistula veinAVF patencyFistula diameterFistula maturationVenous adaptationFistula modelWall thicknessPatencyProtein expressionAKT1 expressionEphrin-B2Lower ratesAkt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression
Luciano AK, Santana JM, Velazquez H, Sessa WC. Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. Journal Of Biological Rhythms 2017, 32: 212-221. PMID: 28452287, PMCID: PMC5703205, DOI: 10.1177/0748730417704534.Peer-Reviewed Original ResearchConceptsCircadian gene expressionCircadian regulatorsAmplitude of expressionGene expressionAkt isoformsIsoforms of AktCircadian transcriptionOrganismal levelPositive regulatorNormal behavioral rhythmsCircadian rhythmPeripheral clocksBehavioral rhythmsAKT1RegulatorAktIsoformsMammalsAmplitude rhythmsDaily rhythmsDifferent functionsLow-amplitude rhythmExpressionEndothelial cellsMice exhibitImproving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasiaPatch Angioplasty in the Rat Aorta or Inferior Vena Cava.
Bai H, Li X, Hashimoto T, Hu H, Foster TR, Hanisch JJ, Santana JM, Dardik A. Patch Angioplasty in the Rat Aorta or Inferior Vena Cava. Journal Of Visualized Experiments 2017 PMID: 28287579, PMCID: PMC5409337, DOI: 10.3791/55253.Peer-Reviewed Original ResearchConceptsInferior vena cavaPatch angioplastyPericardial patchVena cavaNeointimal hyperplasiaInfrarenal inferior vena cavaInfra-renal IVCPericardial patch angioplastyPostoperative day 7Bovine pericardial patchWeek-old Wistar ratsPatch arterioplastyVenous patchArterial patchPatch venoplastyVascular surgeryRat aortaRat modelWistar ratsNeointimal thicknessDay 7Nylon suturesAngioplastyAortaVenous environment
Academic Achievements & Community Involvement
Clinical Care
Overview
Jeans Santana, MD, is an anesthesiologist who specializes in managing patients who are undergoing cardiac procedures, including open heart surgery and electrophysiology studies.
Additionally, Dr. Santana works with patients who need anesthesia for procedures such as abdominal surgery, gallbladder removal, and appendectomy. Most of Dr. Santana’s patients have multiple medical issues such as heart disease, diabetes, or kidney disease.
“I like the challenge of my work and how it makes me slow down every single day,” he says. “Every patient has their own story, their own sensitivities, and their own history. I think cautiously about which anesthetics I'm going to use to make my patients go to sleep comfortably and safely.”
Dr. Santana values the importance of putting patients at ease before giving them anesthesia. “I know how it can be difficult for patients to meet someone on the morning or the afternoon of their surgery. They feel vulnerable, and I get that,” he says. “I try to get my patients to understand that they are in good hands, and they have someone in front of them who has been providing anesthesia services for a number of years, who is certified, and has gone through rigorous training.”
His goal, he says, is to build trust and reduce anxiety.
Clinical Specialties
Anesthesiology; Cardiac Anesthesiology
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2023
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Locations
Department of Anesthesiology
Academic Office
Bridgeport Hospital
267 Grant Street
Bridgeport, CT 06610