2024
Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J. Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling. Journal Of Biomechanics 2024, 169: 112152. PMID: 38763809, PMCID: PMC11141772, DOI: 10.1016/j.jbiomech.2024.112152.Peer-Reviewed Original ResearchAdult aortaTGFB signalingSmooth muscle cellsAortic remodelingCardiac-inducedMouse modelNormal mechanical loadingMuscle cellsPostnatal developmentHemodynamic loadNormal loadAortaMechanical homeostasisMechanical loadingMultiscale computational modelIncreasing loadLoadCell signalingGene productsStructural integrity
2019
Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension
Latorre M, Bersi MR, Humphrey JD. Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension. International Journal Of Engineering Science 2019, 141: 35-46. PMID: 32831391, PMCID: PMC7437922, DOI: 10.1016/j.ijengsci.2019.05.014.Peer-Reviewed Original ResearchAortic remodelingBlood pressure elevationCentral artery stiffnessMajor risk factorCommon mouse modelsBasic science studiesUncontrolled hypertensionIndicators of diseaseAortic stiffeningPressure elevationAdventitial fibrosisArtery stiffnessAortic growthRisk factorsAbdominal aortaCardiovascular diseaseMouse modelTherapeutic strategiesHypertensionAortic wallCompensatory increaseInflammationFibrosisDiseaseMarked increase