2024
High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas
Sandooja R, Saini J, Kittithaworn A, Gregg-Garcia R, Dogra P, Atkinson E, Yu K, Fell V, Simha V, Connelly M, Dullaart R, Bancos I. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae392. PMID: 38870260, DOI: 10.1210/clinem/dgae392.Peer-Reviewed Original ResearchTriglyceride-rich lipoprotein particlesNonfunctioning adenomasCushing's syndromePatient categoriesLow density lipoprotein particlesSex-adjusted analysesHigh density lipoprotein particlesApoB concentrationsLipid lowering drug therapyCross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAdrenal cortical adenomaAutonomous cortisol secretionLipid lowering therapyLipoprotein particlesMultivariate logistic analysisIncreased cardiovascular riskLow density lipoprotein particle concentrationAge- and sex-adjusted analysesStudy of patientsCross sectional studyCortical adenomaCortisol excessLowering therapyEnhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Kittithaworn A, Dogra P, Saini J, Gruppen E, Atkinson E, Achenbach S, Yu K, Thangamuthu K, Connelly M, Dullaart R, Bancos I. Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae204. PMID: 38546526, DOI: 10.1210/clinem/dgae204.Peer-Reviewed Original ResearchMild autonomous cortisol secretionBranched-chain amino acidsMalignant adrenal massesNonfunctioning adenomasCushing's syndromeAdrenocortical carcinomaAdrenal massPrimary aldosteronismAdrenal disordersIncreasing TMAONon-functioning adrenal massesIncreased branched-chain amino acidsIncreased BCAACross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAutonomous cortisol secretionTrimethylamine N-oxideKetone bodiesAdrenal hormone excessSimilar to patientsMultivariate logistic analysisIncreased cardiovascular riskMetabolite trimethylamine N-oxideStudy of patients
2023
Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study
Li D, Zhang C, Saini J, Singh S, Nathani R, Thangamuthu K, Suresh M, Atkinson E, Achenbach S, Van Gompel J, Young W, Bancos I. Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study. European Journal Of Endocrinology 2023, 189: 40-49. PMID: 37327378, PMCID: PMC10376436, DOI: 10.1093/ejendo/lvad069.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionQuality of lifeReduced muscle strengthCushing's syndromeMuscle strengthEndogenous hypercortisolismComponent scoresPhysical component of SF36Sit-to-stand test performanceHealth-related quality of lifeSF36 mental component scoreMuscle functionSeverity scoreReference subjectsMental component scorePhysical component scoreHealth-related qualityAutonomous cortisol secretionClinical severity scoreMuscle strength impairmentCross-sectional studyDeterminants of muscle functionStrength impairmentsAdrenal CSEctopic CS