Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia
Chung K, Ullah I, Yi Y, Kang E, Yun G, Heo S, Kim M, Chung S, Park S, Lim J, Lee M, Rhim T, Lee S. Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia. Pharmaceutics 2024, 16: 290. PMID: 38399343, PMCID: PMC10892455, DOI: 10.3390/pharmaceutics16020290.Peer-Reviewed Original ResearchExtrinsic apoptosis pathwayIntrinsic apoptosis pathwayApoptosis pathwayNeuronal cell deathRelease of cytochrome c.Cell deathInhibit Fas signalingNona-arginine peptideFas-signalingFas signalingConfocal microscopy analysisMitochondria disruptionMiddle cerebral artery occlusionFas receptorIntrinsic pathwayTargeting BaxCytochrome c.Molecular mechanismsCellular apoptosisLigand signalingBaxBrain ischemiaPathwayTreatment of brain ischemiaSiRNA complexesSystemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia
Chung S, Yi Y, Ullah I, Chung K, Park S, Lim J, Kim C, Pyun S, Kim M, Kim D, Lee M, Rhim T, Lee S. Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia. International Journal Of Molecular Sciences 2024, 25: 661. PMID: 38203830, PMCID: PMC10780202, DOI: 10.3390/ijms25010661.Peer-Reviewed Original ResearchConceptsBlood-brain barrierNeuronal cell deathCentral nervous systemBrain ischemiaIschemic strokeSystemic administrationLeptin receptor-deficient db/db miceDb/db miceLeptin peptideCerebral ischemic strokeCell deathInfarct volumeNeuronal injurySystemic treatmentDb miceBBB penetrationIschemic regionNervous systemNeurological disordersTherapeutic potentialSystemic deliveryIschemiaTherapeutic drugsInfarction regionAdministration