2018
Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B. Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism. Stroke 2018, 49: 2173-2181. PMID: 30354983, DOI: 10.1161/strokeaha.118.020586.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetoacetatesAnimalsAstrocytesBlood GlucoseBrainBrain IschemiaCell DeathCerebrovascular CirculationDisease Models, AnimalElectrophysiological PhenomenaEndothelin-1HemodynamicsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicroinjectionsNeuronsRatsReactive Oxygen SpeciesSensorimotor CortexConceptsBody β-hydroxybutyrateFunctional recoveryMagnetic resonance imagingIschemic insultNeuronal deathResonance imagingFocal cortical strokeVehicle-administered animalsNeurological deficit scoresKetone body β-hydroxybutyrateNeuronal glucose uptakeContinuous arterial spinReduced oxidative stressPurpose Recent evidenceReactive oxygen species productionCortical microinjectionsCortical strokePostischemic hyperglycemiaDeficit scoresNeurovascular functionAcute phaseCerebrovascular reactivitySensorimotor cortexCerebral hemodynamicsEndothelin-1
2014
A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles
Oakden W, Kwiecien JM, O’Reilly M, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal Of Neuroscience Methods 2014, 235: 92-100. PMID: 24970578, DOI: 10.1016/j.jneumeth.2014.06.018.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryMagnetic resonance imagingNon-surgical modelCord injurySpinal cordModel of SCIHuman spinal cord injuryT2-weighted magnetic resonance imagingFocused ultrasoundSpinal cord contusionCervical spinal cord damageSurgical incision siteSpinal cord damagePost-operative imagingCervical spinal cordDorsal spinal cordPost-operative careExtent of injuryDegree of injuryCord contusionAcute phaseCord damageVertebral systemSignal abnormalities