Evelyn Lake, PhD
Associate Professor of Radiology and Biomedical ImagingCards
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Research
Publications
2026
Optimizing functional connectivity scanning conditions for predicting autistic traits
Horien C, Mandino F, Greene A, Shen X, Powell K, Vernetti A, O’Connor D, Adkinson B, Tejavibulya L, McPartland J, Volkmar F, Chun M, Chawarska K, Lake E, Rosenberg M, Satterthwaite T, Scheinost D, Finn E, Constable R. Optimizing functional connectivity scanning conditions for predicting autistic traits. Nature Mental Health 2026, 4: 792-805. PMID: 42137910, PMCID: PMC13167459, DOI: 10.1038/s44220-026-00623-7.Peer-Reviewed Original Research
2025
Transdiagnostic similarities and distinctions in brain networks associated with autistic social impairments: a prospective cohort study
Bruno J, Plank J, Leder S, Lake E, Finn E, Green T. Transdiagnostic similarities and distinctions in brain networks associated with autistic social impairments: a prospective cohort study. Molecular Autism 2025, 16: 56. PMID: 41257798, PMCID: PMC12628569, DOI: 10.1186/s13229-025-00686-w.Peer-Reviewed Original ResearchCharting the path in rodent functional neuroimaging
Gozzi A, Stuefer A, Alvino F, Bedin V, Cover C, Kang C, Galbusera A, Gil R, Gini S, de Guzman E, Desrosiers-Grégoire G, Gutierrez-Barragan D, Mandino F, Mariani J, Micotti E, Reimann H, Pagani M, Pepe C, Sastre-Yagüe D, Urosevic M, Valente M, Vertullo R, Canese R, Devor A, Grandjean J, Kahn I, Keiholz S, Lake E, Li N, Shemesh N, Shih Y, Zerbi V, Zhang N. Charting the path in rodent functional neuroimaging. Imaging Neuroscience 2025, 3: imag.a.12. PMID: 40800991, PMCID: PMC12319733, DOI: 10.1162/imag.a.12.Peer-Reviewed Original ResearchSimultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease
Mandino F, Shen X, Fredericks C, Strittmatter S, Lake E. Simultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0828.Peer-Reviewed Original ResearchNeural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI.
Mandino F, Horien C, Shen X, Papademetris X, Keilholz S, Xu N, Lake E. Neural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1012.Peer-Reviewed Original ResearchMultimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino F, Horien C, Shen X, Desrosiers-Grégoire G, Luo W, Markicevic M, Constable R, Papademetris X, Chakravarty M, Betzel R, Lake E. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Communications Biology 2025, 8: 665. PMID: 40287579, PMCID: PMC12033268, DOI: 10.1038/s42003-025-08037-4.Peer-Reviewed Original ResearchPTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, PMCID: PMC12038823, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original Research
2024
Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024, 41: 2528-2544. PMID: 39096127, PMCID: PMC11698675, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchAging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Mandino F, Shen X, Desrosiers-Grégoire G, O’Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator. Molecular Psychiatry 2024, 30: 1730-1745. PMID: 39424929, PMCID: PMC12015114, DOI: 10.1038/s41380-024-02779-z.Peer-Reviewed Original ResearchVentricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus
Herman J, Rittenhouse N, Mandino F, Majid M, Wang Y, Mezger A, Kump A, Kadian S, Lake E, Verardi P, Conover J. Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus. Frontiers In Neuroscience 2024, 18: 1429829. PMID: 39145299, PMCID: PMC11322059, DOI: 10.3389/fnins.2024.1429829.Peer-Reviewed Original Research
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