Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma
Gaglia G, Burger M, Ritch C, Rammos D, Dai Y, Crossland G, Tavana S, Warchol S, Jaeger A, Naranjo S, Coy S, Nirmal A, Krueger R, Lin J, Pfister H, Sorger P, Jacks T, Santagata S. Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Cancer Cell 2023, 41: 871-886.e10. PMID: 37059105, PMCID: PMC10193529, DOI: 10.1016/j.ccell.2023.03.015.Peer-Reviewed Original ResearchConceptsAnti-cancer immune responseImmune checkpoint blockade therapyAnti-tumor responseCheckpoint blockade therapyTreatment of miceAnti-cancer functionCell antigen expressionBlockade therapyCytotoxic CD8PD-1Immune surveillanceLung tumorsAntigen expressionImmune responseIntratumoral localizationLung adenocarcinomaMouse modelB cellsCD8Cell populationsLymphocytesTumorsCell clustersProgenitor differentiationCXCR3