2020
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
O'Mara A, Johnson J, Linderman J, Brychta R, McGehee S, Fletcher L, Fink Y, Kapuria D, Cassimatis T, Kelsey N, Cero C, Sater Z, Piccinini F, Baskin A, Leitner B, Cai H, Millo C, Dieckmann W, Walter M, Javitt N, Rotman Y, Walter P, Ader M, Bergman R, Herscovitch P, Chen K, Cypess A. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. Journal Of Clinical Investigation 2020, 130: 2209-2219. PMID: 31961826, PMCID: PMC7190915, DOI: 10.1172/jci131126.Peer-Reviewed Original ResearchConceptsBAT metabolic activityIntravenous glucose tolerance testGlucose tolerance testΒ3-AR agonistInsulin sensitivityTolerance testMetabolic diseasesObesity-related metabolic diseasesWhite adipose tissue lipolysisBrown adipose tissue thermogenesisOpen-label studyTotal bile acidsHuman brown fatHigher insulin sensitivityAdipose tissue lipolysisAdipose tissue thermogenesisPET/CTΒ3-adrenergic receptor agonistIntramural Research ProgramChronic pharmacological stimulationMetabolic activityMirabegron therapyMirabegron treatmentPrimary endpointSecondary endpoints
2018
Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron
O'MARA A, CYPESS A, CERO C, JOHNSON J, LINDERMAN J, LEITNER B, FLETCHER L, BRYCHTA R, KAPURIA D, MCGEHEE S, ROTMAN Y. Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron. Diabetes 2018, 67 DOI: 10.2337/db18-1146-p.Peer-Reviewed Original ResearchRate-pressure productNon-esterified fatty acidsBrown adipose tissueSerum non-esterified fatty acidsCold exposureWeeks of treatmentBAT metabolic activityHealthy female volunteersAdrenergic receptor agonistPET/CTΒ3-adrenergic receptor agonistDaily mirabegronCardiovascular stimulationPrimary endpointSecondary endpointsChronic treatmentBAT volumeLiver steatosisMetabolic healthPressure productTreatment optionsInsulin sensitivityPharmacotherapeutic approachesReceptor agonistAcute effects