2020
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
O'Mara A, Johnson J, Linderman J, Brychta R, McGehee S, Fletcher L, Fink Y, Kapuria D, Cassimatis T, Kelsey N, Cero C, Sater Z, Piccinini F, Baskin A, Leitner B, Cai H, Millo C, Dieckmann W, Walter M, Javitt N, Rotman Y, Walter P, Ader M, Bergman R, Herscovitch P, Chen K, Cypess A. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. Journal Of Clinical Investigation 2020, 130: 2209-2219. PMID: 31961826, PMCID: PMC7190915, DOI: 10.1172/jci131126.Peer-Reviewed Original ResearchConceptsBAT metabolic activityIntravenous glucose tolerance testGlucose tolerance testΒ3-AR agonistInsulin sensitivityTolerance testMetabolic diseasesObesity-related metabolic diseasesWhite adipose tissue lipolysisBrown adipose tissue thermogenesisOpen-label studyTotal bile acidsHuman brown fatHigher insulin sensitivityAdipose tissue lipolysisAdipose tissue thermogenesisPET/CTΒ3-adrenergic receptor agonistIntramural Research ProgramChronic pharmacological stimulationMetabolic activityMirabegron therapyMirabegron treatmentPrimary endpointSecondary endpoints
2018
The Existence of Superficial Dorsocervical Brown Adipose Tissue in Women
FLETCHER L, LEITNER B, KIM K, MCGEHEE S, BRYCHTA R, CYPESS A, CHEN K. The Existence of Superficial Dorsocervical Brown Adipose Tissue in Women. Diabetes 2018, 67 DOI: 10.2337/db18-2052-p.Peer-Reviewed Original ResearchBrown adipose tissueBAT depotsAdipose tissueFascial layersInterscapular brown adipose tissueHuman brown adipose tissueBAT metabolic activityCervical brown adipose tissueLean body massDeep fascial layerPET/CTDorsocervical regionBAT activationLean massYoung subjectsHuman newbornsMetabolic diseasesMetabolic activityCold stimulationGlucose uptakeLean tissueCold exposureWomenIntermuscular regionSpecific depots