2021
1-13C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA)
Manoli I, Pass A, Harrington E, Sloan J, Gagné J, McCoy S, Bell S, Hattenbach J, Leitner B, Duckworth C, Fletcher L, Cassimatis T, Galarreta C, Thurm A, Snow J, Van Ryzin C, Ferry S, Mew N, Shchelochkov O, Chen K, Venditti C. 1-13C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA). Genetics In Medicine 2021, 23: 1522-1533. PMID: 33820958, PMCID: PMC8354855, DOI: 10.1038/s41436-021-01143-8.Peer-Reviewed Original ResearchConceptsMethylmalonic acidemiaTransplant recipientsBreath testingSerum methylmalonic acid concentrationsLiver transplant recipientsLiver-directed therapiesBone mineral densityNatural history protocolMethylmalonic acid concentrationsOxidative capacityEnteral bolusRenal functionClinical outcomesCognitive test resultsSerum biomarkersMineral densityClinical studiesTherapeutic effectBreath testHealthy volunteersSurrogate endpointsDisease severityRelated disordersGenomic therapyPatients
2018
Exercise modulates the interaction between cognition and anxiety in humans
Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Balderston NL, Chen KY, Grillon C, Ernst M. Exercise modulates the interaction between cognition and anxiety in humans. Cognition & Emotion 2018, 33: 863-870. PMID: 30032703, PMCID: PMC6344312, DOI: 10.1080/02699931.2018.1500445.Peer-Reviewed Original ResearchConceptsAnxiety-potentiated startleAttention controlTask-relevant stimulus processingInterplay of cognitionThreat of shockThreat interferenceThreat processingWM loadWM taskMemory loadWM performanceStimulus processingCognitive abilitiesAnxiolytic effectsAnxiety disordersCognitionAnxietyType of activityProcessingFuture studiesStartleTaskHealthy volunteersParticipantsImpairmentDifferences in Energy Expenditure between Respiratory Chamber and Metabolic Ward in Inpatient Men and Women
ZHOU M, HOWARD R, RABEL A, SEDMAK C, CAI H, WALTER P, BRYCHTA R, FLETCHER L, LEITNER B, GUO J, SIKDER S, COURVILLE A, BERNSTEIN S, GREWAL S, MUNIYAPPA R, CHEN K, HALL K. Differences in Energy Expenditure between Respiratory Chamber and Metabolic Ward in Inpatient Men and Women. Diabetes 2018, 67 DOI: 10.2337/db18-297-lb.Peer-Reviewed Original ResearchKcal/dayMetabolic wardEnergy expenditureRespiratory chamberClass I obesityNIH Clinical CenterLack of exerciseEnergy expenditure differencesInpatient stayClinical centersHealthy volunteersInpatient menCycle ergometryAverage energy expenditureDaily energy expenditureStudy participantsWardsInpatient roomFurther studiesExpenditure differencesMenDaysWeeksWomenCurrent studyExercise decreases defensive responses to unpredictable, but not predictable, threat
Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Chen KY, Ernst M, Grillon C. Exercise decreases defensive responses to unpredictable, but not predictable, threat. Depression And Anxiety 2018, 35: 868-875. PMID: 29637654, PMCID: PMC6314494, DOI: 10.1002/da.22748.Peer-Reviewed Original ResearchConceptsSessions of exerciseInfluence of exercisePredictable threatSustained responseClinical indicationsHealthy controlsAnxiolytic effectsHealthy volunteersPhasic responseThreat testBehavioral interventionsAnxiety disordersControl activitiesDefensive responsesUnpredictable threatStartle potentiationExercisePotentiationNeurobehavioral mechanismsEyeblink startleResponseUnpredictable shocksProvide cluesDefensive stateThreat responses