2020
MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate
Israni N, Cassimatis T, Fletcher L, Leitner B, Duckworth C, Hattenbach J, Bell S, McGehee S, Brychta R, Courville A, Bernstein S, Muniyappa R, Reitman M, Cypess A, Chen K. MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate. Journal Of The Endocrine Society 2020, 4: mon-593. PMCID: PMC7209218, DOI: 10.1210/jendso/bvaa046.366.Peer-Reviewed Original ResearchAnti-obesity drugsHeart rateBasal metabolic rateEnergy expenditureRespiratory quotientSympathetic nervous system activityRandomized cross-over studyPrespecified primary outcomeSingle-dose effectsDrug-naïve subjectsCross-over studyClinical research unitNervous system activityWhole-room indirect calorimeterLong-term interventionsSelf-reported hungerSecondary outcomesArterial pressureHunger scoresPrimary outcomeWashout periodAppetite suppressionChronic useSingle doseAcute effects
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rate