Attila Feher, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2025
AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study
Yi J, Marcinkiewicz A, Shanbhag A, Miller R, Geers J, Zhang W, Killekar A, Manral N, Lemley M, Buchwald M, Kwiecinski J, Zhou J, Kavanagh P, Liang J, Builoff V, Ruddy T, Einstein A, Feher A, Miller E, Sinusas A, Berman D, Dey D, Slomka P. AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study. The Lancet Digital Health 2025, 7: 100862. PMID: 40382274, PMCID: PMC12126277, DOI: 10.1016/j.landig.2025.02.002.Peer-Reviewed Original ResearchConceptsCT attenuation correctionEpicardial adipose tissueVisceral adipose tissuePrognostic valueAdipose tissuePerfusion imagingMedian follow-up timeHigher visceral adipose tissueIncreased all-cause mortality riskMuscle volume indexAttenuation correctionPredicting all-cause mortalityCardiac perfusion imagingKaplan-Meier curvesAll-cause mortality riskBody composition measurementsCox regression modelsAll-cause mortalityReduced riskVolumetric measurementsIntramuscular adipose tissueMortality risk stratificationAI-based segmentationSubcutaneous adipose tissueIndex volumeRacial and Ethnic Differences Among Patients Referred for Noninvasive Coronary Artery Disease Evaluation.
Wright CX, Spatz ES, Miller EJ, Feher A. Racial and Ethnic Differences Among Patients Referred for Noninvasive Coronary Artery Disease Evaluation. JACC Cardiovasc Imaging 2025, 18: 618-620. PMID: 40183731, DOI: 10.1016/j.jcmg.2025.01.017.Peer-Reviewed Original ResearchDeep learning-enabled, computed-tomography-based race- and sex-specific epicardial adipose tissue thresholds for cardiovascular risk stratification
Buchwald M, Shanbhag A, Miller R, Zhang W, Michalowska A, Killekar A, Lemley M, Kavanagh P, Fujito H, Liang J, Builoff V, Knight S, Einstein A, Miller E, Feher A, Sinusas A, Chareonthaitawee P, Bullock-Palmer R, Di Carli M, Berman D, Dey D, Slomka P. Deep learning-enabled, computed-tomography-based race- and sex-specific epicardial adipose tissue thresholds for cardiovascular risk stratification. Progress In Biomedical Optics And Imaging 2025, 13410: 1341011-1341011-7. DOI: 10.1117/12.3047613.Peer-Reviewed Original ResearchEpicardial adipose tissueAmount of epicardial adipose tissueComputed tomography attenuation correctionVolume of epicardial adipose tissueSex-specific thresholdsMyocardial infarctionCardiac sizeFollow-upEAT valuesEpicardial adipose tissue densityFamily history of coronary artery diseaseHistory of coronary artery diseaseHeart sizeLeft ventricle sizeBody surface areaNonfatal myocardial infarctionBody mass indexCoronary artery diseaseRisk of deathCardiovascular risk stratificationCigarette smoking statusPrognostic valueRetrospective studyRisk stratificationVentricle sizeAutomated computation of the HEART score with the GPT-4 large language model
Wright D, Socrates V, Huang T, Safranek C, Sangal R, Dilip M, Boivin Z, Srica N, Wright C, Feher A, Miller E, Chartash D, Taylor R. Automated computation of the HEART score with the GPT-4 large language model. The American Journal Of Emergency Medicine 2025, 93: 120-125. PMID: 40184662, PMCID: PMC12202168, DOI: 10.1016/j.ajem.2025.03.065.Peer-Reviewed Original ResearchConceptsClinical decision supportHEART scoreChest pain observation unitAverage heart scoreCohen's weighted kappaDecision supportNurse practitionersPhysician assistantsRetrospective cohort studyRoutine careCases of disagreementProspective InvestigationAPP scoresCohort studySafety interventionsPhysician judgmentObservation unitAdverse cardiac eventsInstitutional registryScoresPhysiciansInterventionParticipantsNo significant differenceAppsTHE UTILITY OF SPECT MYOCARDIAL PERFUSION IMAGING TO GUIDE PROGNOSIS AND MANAGEMENT IN ELDERLY: IS THERE AN AGE LIMIT?
Patel K, Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Acampa W, Bateman T, Di Carli M, Dorbala S, Einstein A, Fish M, Kaufmann P, Feher A, Miller E, Ruddy T, Sharir T, Halcox J, Martins M, Hauser M, Dey D, Berman D, Slomka P. THE UTILITY OF SPECT MYOCARDIAL PERFUSION IMAGING TO GUIDE PROGNOSIS AND MANAGEMENT IN ELDERLY: IS THERE AN AGE LIMIT? Journal Of The American College Of Cardiology 2025, 85: 2117. DOI: 10.1016/s0735-1097(25)02601-4.Peer-Reviewed Original ResearchAI-BASED LIVER QUANTIFICATION FROM CARDIAC SPECT/CT ATTENUATION MAPS AND ASSOCIATION OF HEPATIC STEATOSIS WITH MORTALITY
Yi J, Patel K, Marcinkiewicz A, Shanbhag A, Miller R, Killekar A, Lemley M, Zhou J, Liang J, Ramirez G, Builoff V, Ruddy T, Einstein A, Feher A, Miller E, Berman D, Dey D, Slomka P. AI-BASED LIVER QUANTIFICATION FROM CARDIAC SPECT/CT ATTENUATION MAPS AND ASSOCIATION OF HEPATIC STEATOSIS WITH MORTALITY. Journal Of The American College Of Cardiology 2025, 85: 2022. DOI: 10.1016/s0735-1097(25)02506-9.Peer-Reviewed Original ResearchTemporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes
Nikolakopoulos I, Csecs I, Liu Y, Sinusas A, Miller E, Feher A. Temporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes. Journal Of Nuclear Cardiology 2025, 48: 102194. PMID: 40139484, DOI: 10.1016/j.nuclcard.2025.102194.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingEvaluation of coronary artery diseasePositron emission tomographyClinical risk factorsMyocardial flow reserveCoronary artery diseasePositron emission tomography myocardial perfusion imagingRates of major-adverse cardiovascular eventsCardiovascular outcomesArtery diseaseFlow reserveMedian follow-up timeRisk factorsLong-term major adverse cardiovascular eventsHistory of heart transplantationC-statisticMedian interval timeKaplan-Meier methodFollow-up timeAdverse cardiovascular eventsChest painTransplant vasculopathyMyocardial blood flowHeart transplantationHolistic AI analysis of hybrid cardiac perfusion images for mortality prediction
Marcinkiewicz A, Zhang W, Shanbhag A, Miller R, Lemley M, Ramirez G, Buchwald M, Killekar A, Kavanagh P, Feher A, Miller E, Einstein A, Ruddy T, Liang J, Builoff V, Ouyang D, Berman D, Dey D, Slomka P. Holistic AI analysis of hybrid cardiac perfusion images for mortality prediction. Npj Digital Medicine 2025, 8: 158. PMID: 40082599, PMCID: PMC11906890, DOI: 10.1038/s41746-025-01526-0.Peer-Reviewed Original ResearchMyocardial perfusion imagingComputed tomography attenuation correctionCoronary calciumPerfusion imagingMortality predictionReceiver-operating characteristic curveAttenuation correctionCoronary calcium scoreEpicardial fat measurementComprehensive multimodal approachCalcium scoreClinical featuresRadiomic featuresClinical assessmentCardiac perfusion imagingCharacteristic curveMultimodal approachPathological informationFat measurementsMortalityPatientsArtificial intelligenceStress testCalciumAI analysisSignificance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesIs it solid enough? Diagnostic performance of solid-state detector technology without attenuation CT against invasive angiography
Feher A, Al-Mallah M. Is it solid enough? Diagnostic performance of solid-state detector technology without attenuation CT against invasive angiography. Journal Of Nuclear Cardiology 2025, 45: 102163. PMID: 39922531, DOI: 10.1016/j.nuclcard.2025.102163.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Attila Feher, MD, PhD, is a cardiologist who specializes in multimodality cardiovascular imaging, which involves analyzing pictures of the heart taken with the help of such technologies as CT scan, MRI, and nuclear imaging. He also has a special interest in preventing and managing heart disease in patients who have underlying autoimmune and rheumatologic disorders through Yale Medicine’s Cardio-Rheumatology Program.
Dr. Feher says a curiosity of human biology inspired him to study medicine, but it was during his training, when he began to interact with patients, that he knew he’d chosen the right path.
“Understanding patients’ inner feelings and helping them emotionally has always been as important to me as understanding the nature of their medical conditions,” Dr. Feher says. “I truly believe in and try to practice the instruction left by Sir William Osler, MD, one of the greatest internists of the 20th century, about keeping the patient in the center: ‘Care more particularly for the individual patient than for the special features of the disease.’”
Dr. Feher says caring for cardiology patients provides him with many opportunities to build long-lasting relationships, which are especially important in cardio-rheumatology, since autoimmune disease requires continuous monitoring. “I think meaningful interactions and paying attention to the details while keeping the patient's needs in the center are key to successfully prevent, treat, and potentially cure cardiovascular disease,” he says.
Dr. Feher’s research interests include studying the impact of autoimmune conditions on cardiovascular health, and the best ways to apply cardiovascular imaging techniques to the evaluation of coronary microvascular disease. “My clinic actively shapes my research,” he says. “I believe the bedside is the perfect place to find research topics that are relevant not only to scientists, but to patients as well.”
Clinical Specialties
Cardiovascular Medicine
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2021
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
News
News
- September 10, 2024
Microvasculature Imaging Shows Promise for Peripheral Artery Disease Management
- July 03, 2024
Gallegos and Feher Join the Journal of Nuclear Cardiology’s Early Career Editorial Board
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 05, 2024
Yale Team Wins American Society of Nuclear Cardiology Award for Cardiology Decision Support Tool
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