Zonation, ligand and dose dependence of S1PR1 signalling in blood and lymphatic vasculature
Del Gaudio I, Nitzsche A, Boyé K, Bonnin P, Poulet M, Nguyen T, Couty L, Ha H, Nguyen D, Cazenave-Gassiot A, Alaya K, Thérond P, Chun J, Wenk M, Proia R, Henrion D, Nguyen L, Eichmann A, Camerer E. Zonation, ligand and dose dependence of S1PR1 signalling in blood and lymphatic vasculature. Cardiovascular Research 2024, cvae168. PMID: 39086170, DOI: 10.1093/cvr/cvae168.Peer-Reviewed Original ResearchHigh endothelial venulesS1PR1 signalingEndothelial functionS1P productionDisease states associated with endothelial dysfunctionPlasma S1PDose-dependentlyLymphatic vasculatureEndothelial cellsResistance-sized arteriesLevels of sphingosine 1-phosphateLung capillariesS1P receptor 1Sphingosine 1-phosphateImmunosuppressive therapyLigand-independent mechanismResistance arteriesLymph nodesDeficient miceAlbumin extravasationHematopoietic cellsCirculating levelsEndothelial dysfunctionS1P releaseCirculating biomarkers