2021
Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Correa R, Blau J, Demidowich A, Stratakis C, Muniyappa R. Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism. Endocrine 2021, 72: 96-103. PMID: 33462741, PMCID: PMC8087621, DOI: 10.1007/s12020-020-02576-y.Peer-Reviewed Original ResearchConceptsΒ-cell functionHepatic insulin resistance indexOral glucose tolerance testPancreatic β-cell functionInsulin sensitivityInsulinogenic indexDisposition indexEffects of hyperaldosteronismCross-sectional study designInsulin resistance indexGlucose tolerance testOral disposition indexSimilar glucose toleranceBackgroundPrimary aldosteronismExcess aldosteronePA cohortArterial pressurePrimary aldosteronismGlucose toleranceControl subjectsTolerance testLess insulinResistance indexPA subjectsInsulin action
2019
OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Demidowich A, Correa R, Blau J, Stratakis C, Muniyappa R. OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism. Journal Of The Endocrine Society 2019, 3: or31-6. PMCID: PMC6554914, DOI: 10.1210/js.2019-or31-6.Peer-Reviewed Original ResearchOral glucose tolerance testΒ-cell functionBeta-cell functionHepatic insulin resistance indexPancreatic beta-cell functionPrimary aldosteronismHepatic insulin sensitivityInsulin sensitivityInsulinogenic indexDisposition indexGlucose tolerancePA groupPancreatic β-cell functionIslet β-cell functionInsulin resistance indexMean arterial pressureGlucose tolerance testOral disposition indexType 2 diabetesSimilar glucose toleranceMinimal model analysisExcess aldosteronePA cohortElevated aldosteroneRenin levels