Immunotherapy and brain metastasis in lung cancer: connecting bench side science to the clinic
Rios-Hoyo A, Arriola E. Immunotherapy and brain metastasis in lung cancer: connecting bench side science to the clinic. Frontiers In Immunology 2023, 14: 1221097. PMID: 37876939, PMCID: PMC10590916, DOI: 10.3389/fimmu.2023.1221097.Peer-Reviewed Original ResearchConceptsBrain metastasesCell lung cancerLung cancerTumor cellsTreatment strategiesAnti-CTLA-4 antibodyManagement of brain metastasesPD-1/PD-L1 axisNon-small cell lung cancerSmall cell lung cancerBrain parenchymaEra of immunotherapyIntracranial malignant neoplasmsSequence of immunotherapySymptomatic brain metastasesImmune checkpoint inhibitorsPD-1/PD-L1Extravasation of tumor cellsTreatment of BMBlood-brain barrierCheckpoint inhibitorsDismal prognosisImmune cellsLocal invasionProtumor effects