Yale researcher Karthik Murugiah, MBBS, an instructor in the Section of Cardiovascular Medicine, has been awarded a five-year K08 career development award from the National Heart, Lung, and Blood Institute (NHLBI).
His project proposes to create and validate automated algorithms that can apply natural language processing techniques to electronic health record (EHR) data to detect two important clinical events after percutaneous coronary intervention. They are hospital bleeding and one-year target lesion revascularization - a common focus of clinical trials and quality improvement efforts.
In addition to performing complex coronary and other vascular interventions, Murugiah has an interest in studying and improving the treatment of heart disease using multidimensional datasets and EHR data to develop real time risk prediction models, decision support tools, and conduct comparative effectiveness studies. During the award period he will build on the experience of his mentorship team, which includes national experts in cardiovascular outcomes research, clinical informatics, and computational linguistics, and also acquire training in clinical informatics.
Mentors and collaborators on the K08 award include Harlan Krumholz MD, SM, Harold H. Hines Jr. Professor of Medicine (Cardiology) and professor of investigative medicine and of public health (health policy), and director of the Center for Outcomes Research & Evaluation (CORE); and Jeptha Curtis, MD, associate professor of medicine (cardiology), as well as Cynthia Brandt MD, MPH, professor of emergency medicine and of anesthesiology at Yale School of Medicine, and of biostatistics at Yale School of Public Health; and Dragomir Radev, PhD, A. Bartlett Giamatti Professor of Computer Science.
Murugiah has built a career as an interventional cardiologist and health services researcher at CORE, and co-authored numerous studies with the China PEACE Collaborative Group evaluating the predominance of a lethal form of heart disease that results from a blocked artery called STEMI. He is also involved in the development and maintenance of performance measures for the Centers for Medicare and Medicaid Services (CMS).
“Karthik is a gifted, caring physician who is poised to make critical contributions to advancing the care of cardiac patients and the lives of patients. Before fellowship, he invested in developing a strong foundation of research skills that now positions him to pursue complex questions and illuminate opportunities for us to augment medical evidence,” said Krumholz.
Murugiah attended medical school at the All India Institute of Medical Sciences, in New Delhi. He subsequently completed his internship and residency in internal medicine at the Albert Einstein College of Medicine Jacobi Medical Center, followed by a two-year postdoctoral research fellowship at CORE. His clinical fellowships in Cardiovascular Medicine and Interventional Cardiology have been at Yale New Haven Hospital. He was appointed as an instructor at Yale School of Medicine in 2019.
Murugiah has authored over 60 peer-reviewed publications. He is also the recipient of the Albert Einstein College of Medicine, Leo M. Davidoff Society Outstanding Achievement in Teaching of Medical Students Award.
The K08 NIH Award goes into effect on January 25, 2022.