Marc Potenza, PhD, MD
Steven M. Southwick Professor of Psychiatry and Professor in the Child Study Center and of NeuroscienceCards
Appointments
Additional Titles
Director, Center of Excellence in Gambling Research
Director, Yale Program for Research on Impulsivity and Impulse Control Disorders
Director, Women and Addictive Disorders, Women's Health Research at Yale
Contact Info
Psychiatry
I Church Street, 7th floor
New Haven, CT 06510
United States
Appointments
Additional Titles
Director, Center of Excellence in Gambling Research
Director, Yale Program for Research on Impulsivity and Impulse Control Disorders
Director, Women and Addictive Disorders, Women's Health Research at Yale
Contact Info
Psychiatry
I Church Street, 7th floor
New Haven, CT 06510
United States
Appointments
Additional Titles
Director, Center of Excellence in Gambling Research
Director, Yale Program for Research on Impulsivity and Impulse Control Disorders
Director, Women and Addictive Disorders, Women's Health Research at Yale
Contact Info
Psychiatry
I Church Street, 7th floor
New Haven, CT 06510
United States
About
Titles
Steven M. Southwick Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience
Director, Center of Excellence in Gambling Research; Director, Yale Program for Research on Impulsivity and Impulse Control Disorders; Director, Women and Addictive Disorders, Women's Health Research at Yale
Biography
Dr. Potenza is a board-certified psychiatrist with sub-specialty training and certification in addiction psychiatry. He has trained at Yale University receiving a combined BS/MS with Honors in Molecular Biochemistry and Biophysics and a PhD in Cell Biology, the latter concurrent with the MD through the Medical Scientist Training Program. He completed internship, psychiatric residency and addiction psychiatry fellowship training at Yale. Currently, he is a Professor of Psychiatry, Child Study and Neuroscience at the Yale University School of Medicine where he is Director of the Division on Addictions Research at Yale, the Center of Excellence in Gambling Research, the Yale Research Program on Impulsivity and Impulse Control Disorders, and the Women and Addictive Disorders Core of Women's Health Research at Yale. He is also a Senior Scientist at the Connecticut Council on Problem Gambling. He is on the editorial boards of fifteen journals (including editor-in-chief of Current Addiction Reports) and has received multiple national and international awards for excellence in research and clinical care. He has consulted to the Substance Abuse and Mental Health Services Administration, National Registry of Effective Programs, National Institutes of Health, American Psychiatric Association and World Health Organization on matters of addiction.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Addictive Behaviors Core
- Center for Brain & Mind Health
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Child Study Center
- Connecticut Mental Health Center
- Diabetes Research Center
- Division of Addictions
- Division of Human Genetics
- Division of Women's Behavioral Health Research
- Interdepartmental Neuroscience Program
- MR Center
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Psychotherapy Development Center
- Stress & Addiction Clinical Research Program
- Substance Abuse Research
- WHRY Research Cores
- Women's Health Research at Yale
- Wu Tsai Institute
- Yale Cocaine Research Clinic
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Program for Research on Impulsivity and Impulse Control Disorders
- Yale Stress Center
- Yale Ventures
Education & Training
- Addiction Psychiatry Fellow
- Yale (1999)
- Resident
- Yale (1998)
- MD
- Yale University School of Medicine (1994)
- PhD
- Yale University (1993)
Research
Overview
Dr. Potenza's research has focused on the neurobiology and treatment of substance and non-substance addictions and other disorders characterized by impaired impulse control, particularly the disorders characterized in DSM-IV as “Impulse Control Disorders Not Elsewhere Classified” and in DSM-5 and ICD-11 as behavioral addictions. He has focused on internet use behaviors and disorders such as gaming disorder and problematic pornography use, as well as compulsive sexual behavior disorder, binge eating disorder and food addiction. He has investigated mechanisms underlying the treatment of cocaine and opioid use disorders, as well as the neural correlates of prenatal cocaine use. Much of this work has focused on understanding clinical and neurobiological underpinnings of these disorders and experiences, and their co-occurrences with other mental health disorders, in order to advance prevention and treatment strategies. Dr. Potenza's research has applied brain imaging, genetic, epidemiological and clinical trials methodologies to gain knowledge and improve prevention and treatment strategies for addictive disorders. This work has also involved a specific focus on gender and identifying potential intermediary phenotypes, like facets of impulsivity, that may in part explain the high rates of co-occurrence between addictive disorders and other mental health conditions, and might represent novel targets for prevention and treatment strategies.
Medical Research Interests
ORCID
0000-0002-6323-1354- View Lab Website
Impulsivity and Impulse Control Disorder Research Program
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Linda Mayes, MD
Elina A. Stefanovics, PhD
Sarah Yip, PhD
Patrick Worhunsky, DPhil
Helena Rutherford, PhD
Robert Pietrzak, PhD, MPH
Gambling
Substance-Related Disorders
Psychotherapy
Publications
2025
Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review
Jalilian-Khave L, Kitaneh R, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review. Addiction Neuroscience 2025, 14: 100190. DOI: 10.1016/j.addicn.2024.100190.Peer-Reviewed Original ResearchAltmetricConceptsImpulse control disordersSubstance use disordersControl disordersBehavioral addictionsTreating impulse control disordersVitamin DClinical studiesAddictive disordersSerotonergic circuitsExposure to vitamin DVitamin D deficiencyVitamin D levelsSymptom presenceDisordersPotential beneficial effectsJoanna Briggs InstituteD deficiencyPotential therapeutic mechanismAddictionD levelsWeb of ScienceTherapeutic mechanismQuality of studiesCochrane LibraryOvid MEDLINE
2024
Cross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages
Castro-Calvo J, Beltrán-Martínez P, Ballester-Arnal R, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Chen L, Ciocca G, Corazza O, Csakó R, Fernandez D, Fernandez E, Fujiwara H, Fuss J, Gabrhelík R, Gewirtz-Meydan A, Gjoneska B, Gola M, Grubbs J, Hashim H, Hsieh Y, Islam S, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee S, Lewczuk K, Lin C, Lochner C, Lopez-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosova O, Orosz G, Team S, Ponce F, Quintana G, Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Štulhofer A, Ünsal B, Vaillancourt-Morel M, Van Hout M, Bőthe B. Cross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages. The Journal Of Sex Research 2024, ahead-of-print: 1-14. PMID: 39560207, DOI: 10.1080/00224499.2024.2417023.Peer-Reviewed Original ResearchAltmetricConceptsSexual Desire InventorySexual desireDesire InventorySDI-2Non-clinical sampleMeasurement invariance testingPsychometrically robust measureSexuality-related variablesConfirmatory factor analysisGroup-based differencesCross-cultural validitySexual orientationCross-cultural studiesPsychometric propertiesInvariance testingEffect sizeFactor analysisWell-beingExpression of sexual desireWeak-to-moderateSexual functionInventorySex surveysLanguageDesireIdentifying Factors Linked to Current Patterns of Alcohol Consumption in U.S. Veterans with a History of Alcohol Use Disorder
Jalilian-Khave L, Stefanovics E, Potenza M, Pietrzak R. Identifying Factors Linked to Current Patterns of Alcohol Consumption in U.S. Veterans with a History of Alcohol Use Disorder. International Journal Of Mental Health And Addiction 2024, 1-18. DOI: 10.1007/s11469-024-01412-y.Peer-Reviewed Original ResearchConceptsHistory of alcohol use disorderAlcohol use disorderUse disorderU.S. veteransHazardous drinkingNational Health and ResilienceLifetime history of alcohol use disorderLifetime alcohol use disorderAlcohol use problemsDrug use disordersPatterns of alcohol consumptionAlcohol use patternsHigher education levelNationally representative sampleMultinomial logistic regression analysisVeterans StudyLifetime historyLifetime traumaAlcohol consumption patternsQuality of lifeNon-veteransLogistic regression analysisPsychosocial traitsTreatment effortsPsychosocial factorsCross-cultural Validation of the Arizona Sexual Experience Scale (ASEX) in 42 Countries and 26 Languages
Ballester-Arnal R, Elipe-Miravet M, Castro-Calvo J, Beltrán-Martínez P, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Chen J, Chen L, Ciocca G, Corazza O, Csako R, Fernandez D, Fernandez E, Fujiwara H, Fuss J, Gabrhelík R, Gewirtz-Meydan A, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam M, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee S, Lewczuk K, Lin C, Lochner C, López-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosová O, Orosz G, Ponce F, Quintana G, Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib S, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Ünsal B, Vaillancourt-Morel M, Van Hout M, Bőthe B. Cross-cultural Validation of the Arizona Sexual Experience Scale (ASEX) in 42 Countries and 26 Languages. Sexuality Research And Social Policy 2024, 1-23. DOI: 10.1007/s13178-024-01040-0.Peer-Reviewed Original ResearchAltmetricConceptsArizona Sexual Experience ScaleSexual Experience ScaleSexual function problemsExperiences ScaleOne-factor solutionSexual functionCross-cultural validitySexual orientationCross-cultural differencesMulti-national sampleAsexual participantsResidual invariancePsychometric examinationConvergent validityPsychometric propertiesSexual function issuesSex driveInternal consistencyPolicy ImplicationsThe findingsImplicationsThe findingsFunctional problemsWell-beingTailored interventionsOrgasmLanguageGlobal action on problematic usage of the internet: announcing a Lancet Psychiatry Commission
Fineberg N, Demetrovics Z, Potenza M, Mestre-Bach G, Ekhtiari H, Roman-Urrestarazu A, Achab S, Kattau T, Bowden-Jones H, Thomas S, Babor T, Kidron B, Stein D. Global action on problematic usage of the internet: announcing a Lancet Psychiatry Commission. The Lancet Psychiatry 2024 PMID: 39427681, DOI: 10.1016/s2215-0366(24)00323-7.Peer-Reviewed Original ResearchCitationsAltmetricPornography Use and Associated Factors in Adolescents: A Cross-Jurisdictional Approach (Spain vs. Mexico)
Villena-Moya A, Chiclana-Actis C, Granero R, Fernández-Aranda F, Potenza M, Jiménez-Murcia S, Mestre-Bach G. Pornography Use and Associated Factors in Adolescents: A Cross-Jurisdictional Approach (Spain vs. Mexico). Archives Of Sexual Behavior 2024, 1-16. PMID: 39414731, DOI: 10.1007/s10508-024-03000-6.Peer-Reviewed Original ResearchAltmetricConceptsPornography useFrequent pornography useNon-heterosexual orientationAdolescent pornography useCross-country differencesRisky sexual behaviorPoor family relationshipsPotential sociocultural factorsSexual risk behaviorsCross-jurisdictional approachFamily relationshipsPornographyCross-jurisdictionalRisk behaviorsSociocultural factorsSexual behaviorJurisdictional differencesLow religiositySpanish-speaking culturesReligiosityMexican sampleSpanish-speaking populationSociodemographic variablesSpanish sampleOlder ageVitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024 PMID: 39395473, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchAltmetricConceptsVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylaseSpanish Validation of the Brief Pornography Screen Within a Clinical Sample of Individuals with Gambling Disorder
Tarragón E, Testa G, Granero R, Potenza M, Kraus S, Uríszar J, Chiclana Actis C, Fernández-Aranda F, Jiménez-Murcia S, Mestre-Bach G. Spanish Validation of the Brief Pornography Screen Within a Clinical Sample of Individuals with Gambling Disorder. Archives Of Sexual Behavior 2024, 53: 3759-3768. PMID: 39358592, DOI: 10.1007/s10508-024-02986-3.Peer-Reviewed Original ResearchAltmetricConceptsBrief Pornography ScreenProblematic pornography useClinical sample of individualsConfirmatory factor analysisGambling disorderSample of individualsPsychometric propertiesLow self-directednessOne-factor solutionAdequate psychometric propertiesClinical samplesGeneral psychopathologySelf-directednessBehavioral addictionsImpulsive tendenciesConvergent validityPornography usePsychological distressScreening instrumentSpanish versionSpanish validationFactor analysisBriefDisordersIndividualsPrediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods. Journal Of Behavioral Addictions 2024, 13: 695-701. PMID: 39356557, PMCID: PMC11457034, DOI: 10.1556/2006.2024.00050.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAddictive behaviorsDisorders due to addictive behaviorsConnectome-based predictive modelingPrediction of cravingInvestigate neural mechanismsSubstance use disordersNeural mechanismsCravingSubstance useMethodological considerationsDisordersMethodological featuresBehaviorConceptualizationCommentaryStudyFindingsSubstancesGambling and Substance Use Disorders in U.S. Military Veterans: Prevalence, Clinical Characteristics, and Suicide Risk
Stefanovics E, Potenza M, Tsai J, Pietrzak R. Gambling and Substance Use Disorders in U.S. Military Veterans: Prevalence, Clinical Characteristics, and Suicide Risk. Journal Of Gambling Studies 2024, 40: 2119-2139. PMID: 39342537, DOI: 10.1007/s10899-024-10359-7.Peer-Reviewed Original ResearchConceptsSubstance use disordersU.S. military veteransMental health treatmentGambling groupSUD-onlySuicide riskHealth treatmentMilitary veteransNon-suicidal self-injuryLifetime substance use disorderNational Health and ResilienceRisk of substance use disordersSUD-only groupSelf-report measuresMental health difficultiesAdverse childhood experiencesMental health burdenPast-year gamblingSelf-injurySuicidality/self-harmVeterans StudyUse disorderNicotine dependenceTrauma variablesBehavioral correlates
Clinical Trials
Current Trials
Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD
HIC ID2000020604RolePrincipal InvestigatorPrimary Completion Date12/31/2021Recruiting ParticipantsGenderBothAge18 years - 50 years
Academic Achievements & Community Involvement
honor Doctor et Professor Honoris Causa (Honorary Doctorate and Professor in Psychological Science), Eötvös Loránd University
International AwardDetails05/10/2019Hungaryhonor Phoenix Award for Achievement in Addiction Research, the Green Crescent Society
International AwardDetails05/03/2018Turkeyhonor Research Award, Society for the Advancement of Sexual Health
National AwardDetails09/14/2017United Stateshonor Lifetime Research Award, the National Council on Problem Gambling
National AwardDetails06/16/2016United Statesactivity Gambling
ResearchDetails01/01/2008 - PresentCanadaAbstract/SynopsisDr. Potenza is involved in a think-tank and work group through McGill University in Montreal focusing on adolescent gambling.
News
News
- December 20, 2024
Mentoring the Next Generation
- December 11, 2024
Current Advances in Behavioral Addictions: From Fundamental Research to Clinical Practice
- November 14, 2024Source: The New York Times
How Tech Created a ‘Recipe for Loneliness’
- October 24, 2024
Carolyn M. Mazure Receives Elga R. Wasserman Award
Get In Touch
Contacts
Psychiatry
I Church Street, 7th floor
New Haven, CT 06510
United States