Because the clinical use of biomedical knowledge often draws upon information from multiple disciplines, the content in the course has been integrated and organized into themes that reflect key biomedical processes:
- Building a Body
- Fluids and Gradients
- Gene Expression
- Cell Energy
- Cell Communication
- Life and Death of a Cell
Each theme connects basic science with clinical medicine through discussions of relevant disease processes and seminal discoveries of treatments.
- Optional weekly quizzes
- One mandatory, mid-course self-assessment
- End-of-course, pass/fail qualifier
- Students should be able to define the volumes and composition of the fluid compartments in the body and the mechanisms by which cells generate and use membrane potential. With this knowledge, students should be able to determine
- Students should be able to diagram the pathways through which ligands and drugs alter cell behavior and calculate the availability, distribution, clearance and efficacy of drugs in patients.
- Students should be able to describe the molecular connections and functional organization of macromolecules, cells and tissues. • Students should be able to describe the regulation of gene expression at the levels of transcription and translation and the mechanisms of protein folding, localization, and degradation.
- Students should be able to list the pathways and major enzymes that allow cells to generate molecules of energy currency (ATP, NADH, NADPH), generate the building blocks of macromolecules (amino acids, nucleotides, and fatty acids), and metabolize macromolecules.
- Students should be able to describe the basic pathways and mechanisms that regulate cell division and the responses of cells to injury.
- Students should be able to use the knowledge gained in the course to analyze clinical cases and describe how the molecular, cellular, or physiological changes in a patient result in clinical symptoms.