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Carson Thoreen, PhD

Associate Professor Term of Cellular & Molecular Physiology
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About

Titles

Associate Professor Term of Cellular & Molecular Physiology

Appointments

Education & Training

PhD
Massachusettes Institute of Technology (2008)
ScB
Brown University, Biology (2000)

Research

Overview

The mammalian target of rapamycin (mTOR) pathway is an evolutionarily conserved master regulator of cell growth with important roles in metabolism, aging and cancer. The pathway senses nutrient and growth signals, and responds to these by regulating many major metabolic pathways, but particularly mRNA translation. We found that acute inhibition of mTOR selectively inhibits the translation of large class of mRNAs containing a terminal oligopyrimidine (TOP) motif at the 5’ terminus by disrupting the mRNA cap-binding complex, eIF4F. The mTOR pathway has many additional targets in the translational machinery, but the functional significance of these is unknown. We want to understand how mTOR-regulated translational mechanisms work in molecular detail, what features in mRNAs determine their dependence on mTOR activity, and how these controls are employed physiologically.

Medical Subject Headings (MeSH)

Biochemistry; Metabolism; Physiology; Translations

Research at a Glance

Yale Co-Authors

Frequent collaborators of Carson Thoreen's published research.

Publications

2022

2020

2017

2016

2012

2009

2006

2004

Get In Touch

Contacts

Academic Office Number

Locations

  • Sterling Hall of Medicine, B-Wing

    Academic Office

    333 Cedar Street, Ste 163 B

    New Haven, CT 06510