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Kevin Sheth, MD

Professor of Neurology and Neurosurgery; Executive Director of the NNCTU and Vice Chair for Clinical and Translational Research in the Departments of Neurology and Neurosurgery. Director, Yale Center for Brain & Mind Health.
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About

Titles

Professor of Neurology and Neurosurgery; Executive Director of the NNCTU and Vice Chair for Clinical and Translational Research in the Departments of Neurology and Neurosurgery. Director, Yale Center for Brain & Mind Health.

Biography

Dr. Kevin Sheth is a founding Director of the Yale Center for Brain & Mind Health and the Vice Chair for Clinical and Translational Research for the departments of Neurology. and Neurosurgery. He leads prevention efforts in neurologically vulnerable populations and works towards advancing therapies for acute brain injury such as stroke and brain hemorrhage. In pioneering the development of new strategies to treat brain swelling, his work has changed the fundamental approach to brain injury in the ICU and spurred the creation of new technologies in drug delivery and neuroimaging. Highly collaborative, interdisciplinary efforts from the lab have culminated in the first phase III trial to prevent brain swelling in stroke, the first phase III NIH funded prevention trial in brain hemorrhage, and the deployment of the first portable bedside MRI for brain injury in the world. His team at Yale has served as a national model for academic critical care neurology units. In recent years his group has also turned their attention to public health prevention efforts, focusing on cardiometabolic risk factors that can prevent decline in brain health resulting from stroke, dementia, and depression.

He is currently a principal investigator for two NIH neuroscience networks, StrokeNet, and SIREN. He is a multi-PI for four additional RO1/UO1 awards from the NIH. Dr. Sheth has served as PI or co-PI for 8 multicenter clinical trials in stroke. He is a winner of the prestigious Robert Siekert Award from the American Heart Association (AHA), the Derek Denny Brown Award from the American Neurological Association and an elected member of the American Society for Clinical Investigation (ASCI). Most recently, he was the recipient of the Stroke Research Mentorship Award from the American Heart Association. Dr. Sheth is the author of over 300 publications. His work has been showcased in The Washington Post, Wall Street Journal, Scientific American, NPR, and CNN.

Finally, Dr. Sheth has formed exciting partnerships with entrepreneurs, pharmaceutical companies, and medical device start-ups to bring forward highly innovative solutions. These efforts have resulted in extensive knowledge of FDA pathways, development of phase I-III drug programs, and implementation of new technology into the clinical workspace. The principal theme of his efforts are towards collaboration and an improved understanding of neurological disease.

Appointments

Other Departments & Organizations

Education & Training

Fellow, Vascular Neurology & Neurocritical Care
Massachusetts General Hospital/Brigham & Women's Hospital (2009)
Chief Resident
Massachusetts General Hospital/Brigham & Women's Hospital (2007)
Resident
Massachusetts General Hospital/Brigham & Women's Hospital (2006)
Intern
Brigham and Women's Hospital (2004)
MD
University of Pennsylvania Medical School (2003)
BA
Johns Hopkins University (1999)

Research

Overview

Representative Projects

Pre-Clinical

co-Principal Investigator, “Improved Glyburide Therapy Via Acid-Triggered Release Functional Nanoparticles,” (R01NS110721-01A1) - Together with Dr. Jiangbing Zhou, we are developing novel nanoparticle formulations for treatment of acute ischemic stroke. These nanoparticle have unique structural and composition profiles tailored for acute brain injury and have been developed for a number of candidate treatments, as well as penetration and engagement across the blood-brain-barrier.

co-investigator, “Yale Site for Stroke Preclinical Assessment Network (SPAN) for Acute Neuroprotection,” UO1NS113445 - Together with Dr. Lauren Sansing, we are participating in a multi-center preclinical ischemia-reperfusion stroke model network aimed at identifying candidate therapies for stroke translation.

Clinical Trials

Prevention

co-Investigator, Director of the Recruitment Core Lab, “ARCADIA-CSI (Cognition and Silent Infarcts),” U01NS110728 - Together with Dr. Maarten Lansberg at Stanford, this study will evaluate the role of silent brain infarction on functional and cognitive outcome after stroke caused by cardioembolism. It will also provide information on whether or not anticoagulation may modify this outcome.

co-Principal Investigator, “Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)”, NINDS, U01NS106513 - Together with Dr. Hooman Kamel at Cornell, I am leading this phase III StrokeNet clinical trial which will enroll 700 patients at 125 US centers who survive intracerebral hemorrhage and also have atrial fibrillation. The study will determine whether or not anticoagulation or aspirin results in improved stroke prevention and survival

co-Principal Investigator, “The Recovery in Stroke Using PAP: RISE-UP” Study”, NINR, RO1NR018335 - Together with Dr. Klar Yaggi, this randomized control trial, funded by the NINR, will examine whether or not sleep apnea treatment using positive airway pressure therapy can improve functional outcome and other patient centered symptoms in 180 patients. We will also obtain unique information in this population regarding adherence and qualitative benefit.

Acute Treatment

co-Principal Investigator - INTREPID (Impact of Fever Prevention in Brain Injured Patients) (Sponsor: Bard) - This is a phase III study of over 1000 ischemic and hemorrhagic stroke patients testing the following hypothesis: does fever prevention, using an advanced cooling device, result in improved neurology outcomes in patients with severe stroke.

co-Principal Investigator - Saponimod in Intracerebral Hemorrhage (Sponsor: Novartis) - This is a phase II clinical trial of S1P modulation in patients with spontaneous intracerebral hemorrhage at approximately 20 US sites. We will enroll approximately 60 patients in order to obtain information regarding the feasibility of recruitment, evaluation and administration of S1P modulators and to obtain exploratory information regarding imaging measures of swelling and inflammation and clinical outcomes.

co-Global Lead CHARM (Cirara in Large Hemishperic Infarction Analyzing mRS and Mortality) - The CHARM study is an international, multicenter, randomized, double-blind, placebo-controlled, Phase 3 study that aims to enroll 680 patients with LHI in approximately 20 countries. It will evaluate the efficacy and safety of IV glibenclamide treatment within 10 hours following stroke onset. The primary endpoint is the modified Rankin Scale (mRS), a functional outcome, assessed at 90 days. This trial represents over 10 years of a collaborative translational effort from molecular discovery at the bench to phase III trial in stroke patients who are at high risk for brain swelling.

Recovery

Both the ASPIRE and RISE-UP clinical trials are both prevention and recovery clinical trials in stroke.

Neuroscience Clinical Trial Networks

I am the co-Principal Investigator of 2 NIH Networks in New England.

INFINITY (Investigations For Improved Neurological Treatments at Yale) was selected in 2018 by the National Institutes of Neurological Disorders and Stroke (NINDS) as one of approximately 25 U.S. sites designated to participate in the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT). This network conducts both biomarker validation and Phase 2 studies of treatment for neurological disease in adults and children through partnerships with academia, private foundations and industry. NeuroNEXT is designed to expand NINDS's capabilty to test the most promising new therapies; increase the efficiency of clinical trials before on embarking on larger studies; and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders. INFINITY is a highly effective research team which includes both adult and pediatric neurologists, neurosurgeons, neuropsychologists, neuroradiologists, and translational scientists committed to conducting high impact clinical trials in neurological diseases.

SPIRIT (Southern New England Partnership In Stroke Research, Innovation and Treatment) was selected in 2018 by the National Institutes of Health (NIH) as one of approximately 25 U.S. Sites designed to participate in StrokeNet. The primary goal of this network is to maximize efficiencies to develop, promote and conduct high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment and recovery. The StrokeNet Network is designed to serve as the infrastructure and pipeline for exciting new potential treatments for patients with stroke and those at risk for stroke. SPIRIT is anchored by 3 leading institutes: Yale School of Medicine, Warren Alpert School of Medicine at Brown University, and Hartford Hospital

Engineering and Technology

The nanoparticle project above is in collaboration with biomedical engineering at Yale University.

Principal Investigator, “Portable, Bedside Magnetic Resonance Imaging in Neuroscience”, Hyperfine, Inc and American Heart Association - In collaboration with Dr. W.T. Kimberly and Matthew Rosen at Harvard and with Hyperfine, we have developed and deployed the first portable, bedside MRI in the world.

Data Resources and Repository

My group works with a number of "big data" resources, including publicly available clinical trial datasets (e.g. NIH), administrative and claims datasets (e.g., Nationwide Inpatient Sample, Medicare, Healthcare Utilization Project), quality improvement (AHA-Get With the Guidelines), genomics (e.g. UK Biobank) to make and replicate clinically relevant observations and to understand current practice patterns.

co-Principal Investigator, “Intensive Blood Pressure Reduction in Deep Intracerebral Hemorrhage,” RO3NS112859 - This project examines the role of neuroanatomical location and treatment effect in prior clinical trial and observational series of patients with brain hemorrhage.

Mentorship

Our group fosters the development of academic investigators in clinical and translational research in brain injury from the undergraduate to the faculty level. The focus is on the themes and patient populations identified above.

Medical Subject Headings (MeSH)

Biomarkers, Pharmacological; Biotechnology; Brain Edema; Brain Hemorrhage, Traumatic; Brain Infarction; Drug Delivery Systems; Infarction, Middle Cerebral Artery; Neurology; Neurosciences; Neurosurgery; Primary Prevention; Quality of Health Care; Secondary Prevention; Stroke; Subarachnoid Hemorrhage; Trauma, Nervous System

Research at a Glance

Yale Co-Authors

Frequent collaborators of Kevin Sheth's published research.

Publications

2024

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

  • activity

    Neurocritical Care Society

  • activity

    American Heart Association

  • activity

    NINDS

  • activity

    National Aeronautics Space Administration (NASA)

  • activity

    American Society for Clinical Investigation

Clinical Care

Overview

Kevin Sheth, MD is a critical care neurologist at Yale Medicine. He has a particular interest in acute neurological syndromes, especially those complicated by brain swelling and hemorrhage.

Dr. Sheth graduated from Johns Hopkins University and the University of Pennsylvania School of Medicine. He was an intern at Brigham and Women's Hospital and a neurology resident and chief resident at Partners Neurology (Massachusetts General and Brigham & Women's Hospitals). In 2013 he was recruited to Yale as the founding chief of the Division of Neurocritical Care and Emergency Neurology and Chief of Clinical Research for the Department of Neurology.

As a critical care neurologist, Dr. Sheth uses his expertise to stabilize each patient he sees. He takes into account not only the status of the brain, but also the status of all other organs of the body, including the heart, lungs and kidneys. At the same time, he works hard to reach a diagnosis and determine a treatment strategy by using cutting-edge technology, including advanced brain imaging, spinal cord imaging, EEGs and blood tests.

In addition, Dr. Sheth is passionate about supporting and educating families of patients in the neuro-ICU. “It’s a privilege to be there for families whose loved ones were healthy and living their usual lives until, in a split second, there was an unimaginable change,” he says.

Dr. Sheth was initially drawn to neurology as a specialty because of how little is known about the brain and much there is still to discover. “It is one of the frontiers in science and there’s a huge opportunity to make a dent,” he says.

In addition to seeing patients, Dr. Sheth conducts research on new therapies for patients with conditions such as stroke, brain hemorrhage and trauma. He is also actively developing new methods to detect and follow brain swelling.

Dr. Sheth is also an associate professor of neurology and of neurosurgery at the Yale School of Medicine.

Clinical Specialties

Neurocritical Care; Stroke

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