Anjali Sankar
Assistant Professor Adjunct of PsychiatryCards
About
Research
Publications
2024
Magnetic resonance imaging of regional gray matter volume in persons who died by suicide
Deininger-Czermak E, Spencer L, Zoelch N, Sankar A, Gascho D, Guggenberger R, Mathieu S, Thali M, Blumberg H. Magnetic resonance imaging of regional gray matter volume in persons who died by suicide. Molecular Psychiatry 2024, 1-5. PMID: 39237718, DOI: 10.1038/s41380-024-02730-2.Peer-Reviewed Original ResearchNeocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals
Sankar A, Ziersen S, Ozenne B, Dam V, Beaman E, Kessing L, Fisher P, Budtz-Jørgensen E, Knudsen G, Miskowiak K, Frokjaer V. Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals. Nature Mental Health 2024, 1-8. DOI: 10.1038/s44220-024-00299-x.Peer-Reviewed Original ResearchRisk of depressionFacets of neuroticismPersonality trait neuroticismPathophysiology of depressionSerotonin 2A receptorMolecular brain imagingHigh neuroticismTrait neuroticismDepressive episodeNeuroticismDepression diagnosisHealthy individualsDepressionReceptor bindingBrain imagingDanish registersCause-specific Cox regression analysesEvaluation of clinical strategiesIndividualsCox regression analysisPsychotherapyClinical strategiesPsychedelicsSerotoninRegression analysis
2023
Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals
Sankar A, Ozenne B, Dam V, Svarer C, Jørgensen M, Miskowiak K, Frokjaer V, Knudsen G, Fisher P. Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals. Translational Psychiatry 2023, 13: 165. PMID: 37169780, PMCID: PMC10175268, DOI: 10.1038/s41398-023-02440-3.Peer-Reviewed Original ResearchConceptsResponses to emotional facesFunctional magnetic resonance imagingEmotional facesNeural responsesNeural responses to emotional stimuliEmotional face-matching taskNeural processing of emotionResponses to emotional stimuliPositron emission tomographyEmotional processing biasesFace-matching taskProcessing of emotionsHealthy controlsAntidepressant treatmentBrain serotonergicProcessing biasesDepressive disorderEmotional processingEmotional stimuliSerotonergic signalingMDDMatching taskBrain functionLatent variable modelsDepression statusSerotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction
Köhler-Forsberg K, Dam V, Ozenne B, Sankar A, Beliveau V, Landman E, Larsen S, Poulsen A, Ip C, Jørgensen A, Meyer M, Stenbæk D, Eiberg H, Madsen J, Svarer C, Jørgensen M, Frokjaer V, Knudsen G. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry 2023, 80: 296-304. PMID: 36753296, PMCID: PMC9909578, DOI: 10.1001/jamapsychiatry.2022.4539.Peer-Reviewed Original ResearchConceptsMemory dysfunctionUntreated MDDDepressive disorderReceptor bindingHealthy controlsModerate to severe depressive episodePositron emission tomographyMajor depressive disorderSevere depressive episodeVerbal memory performanceNeurobiological signatureDepressive episodeVerbal memoryMemory performanceCognitive domainsDepression trialsMDDDepressive stateBrain bindingCognitive testsCognitive functionGroup differencesAssociated with improved learningSerotonin-4Adult participantsAssociation of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders
Sankar A, Ziersen S, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Frokjaer V, Miskowiak K. Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders. EClinicalMedicine 2023, 58: 101927. PMID: 37007740, PMCID: PMC10050788, DOI: 10.1016/j.eclinm.2023.101927.Peer-Reviewed Original ResearchSocio-demographic conditionsPsychiatric hospitalAffective disordersNeurocognitive impairmentDepressive disorderExecutive functionVerbal memoryNeurocognitive functionNational population-based registersPopulation-based registersAssociation of neurocognitionVerbal memory domainSocio-demographic indicatorsStudies of neurocognitionClinically significant impairmentFuture hospitalsDepression severityMemory domainCox regression modelsIllness durationNeurocognitive assessmentEmployment outcomesSecondary outcomesSignificant impairmentStudy inclusionDeep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
Jensen K, Dam V, Ganz M, Fisher P, Ip C, Sankar A, Marstrand-Joergensen M, Ozenne B, Osler M, Penninx B, Pinborg L, Frokjaer V, Knudsen G, Jørgensen M. Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort. BMC Psychiatry 2023, 23: 151. PMID: 36894940, PMCID: PMC9999625, DOI: 10.1186/s12888-023-04618-x.Peer-Reviewed Original ResearchConceptsQuick Inventory of Depressive SymptomatologyFirst-episode depressionTreatment packageFirst-episode MDD patientsInventory of Depressive SymptomatologyBackgroundMajor depressive disorderSecond-line antidepressantsHeterogeneous brain disordersMarkers of treatment responseMedication side effectsMDD patientsDepressive disorderDepression severityDepressive symptomatologyPrecision psychiatrySymptom ChecklistClinical outcomesNeuroimaging dataBrain positron emission tomographyPublic outpatient clinicsDisability ScalePositron emission tomographyBrain disordersEffect of treatment choiceDepressionRelevance of neuroanatomical abnormalities for cognition and daily functioning in patients with mood disorders
Mariegaard J, Damgaard V, Sankar A, Macoveanu J, Frøkjær V, Kessing L, Jørgensen M, Knudsen G, Miskowiak K. Relevance of neuroanatomical abnormalities for cognition and daily functioning in patients with mood disorders. Neuroscience Applied 2023, 2: 102903. DOI: 10.1016/j.nsa.2023.102903.Peer-Reviewed Original ResearchNetwork-wide aberrant neuronal activity in patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Mariegaard J, Macoveanu J, Sankar A, Petersen J, Frøkjær V, Kessing L, Jørgensen M, Knudsen G, Miskowiak K. Network-wide aberrant neuronal activity in patients with mood disorders: associations with cognitive impairment and functional disability. Neuroscience Applied 2023, 2: 102914. DOI: 10.1016/j.nsa.2023.102914.Peer-Reviewed Original ResearchThe role of combined oral contraceptive use on the serotonin 2A receptor brain architecture in healthy women
Kauffmann A, Larsen S, Ozenne B, Svarer C, Fisher P, Sankar A, Frokjaer V. The role of combined oral contraceptive use on the serotonin 2A receptor brain architecture in healthy women. Neuroscience Applied 2023, 2: 102445. DOI: 10.1016/j.nsa.2023.102445.Peer-Reviewed Original Research
News
News
- July 30, 2021Source: The American Journal of Psychotherapy
Telehealth Social Rhythm Therapy to Reduce Mood Symptoms and Suicide Risk Among Adolescents and Young Adults With Bipolar Disorder
- June 09, 2020
Department's Psychology Section a Major Contributor During COVID-19 Pandemic
- March 22, 2019
Sankar receives competitive travel award to attend Wisconsin Symposium on Emotion