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Michael Kashgarian, MD, FASN

Professor Emeritus of and Senior Research Scientist in Pathology
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About

Titles

Professor Emeritus of and Senior Research Scientist in Pathology

Biography

Michael Kashgarian is professor emeritus of and senior research scientist in pathology. He received his medical degree from Yale School of Medicine in 1958, completed his residency in pathology at the Yale-New Haven Medical Center in 1963, and completed a fellowship in laboratory medicine at Yale-New Haven Hospital in 1964. While on the Yale faculty he established a diagnostic renal pathology and electron microscopy laboratory that bears his name. He was also a pioneer in understanding the process of organ rejection. Although Kashgarian has retired, he continues to be active in the diagnosis of renal and cardiac biopsies.

Appointments

Other Departments & Organizations

Education & Training

Fellow
Yale-New Haven Hospital (1964)
Resident
Yale-New Haven Hospital (1963)
Resident
Barnes Hospital/Washington University (1959)
MD
Yale University (1958)

Board Certifications

  • Medicolegal Pathology

    Certification Organization
    AB of Pathology
    Original Certification Date
    1968
  • Anatomic & Clinical Pathology

    Certification Organization
    AB of Pathology
    Original Certification Date
    1967

Research

Overview

Research in my laboratory was directed in three main investigative areas. We study the structural and functional characteristics of transporting epithelia, in particular the cellular mechanisms involved in adaptive changes in response to steroid hormones and changes in the external ionic milieu. The second area of investigation is of the mechanisms involved in the recovery from acute renal failure. These studies concentrate on the contribution of the cytoskeleton to the reorganization of the micro domain distribution of Na,K-ATPase as well as investigating the role of the synthesis and recycling of integral membrane proteins and the contribution of heat shock proteins in this process. Finally, we are also investigating the factors involved in the initiation and progression of glomerulus scarring by defining the pathogenetically relevant parameters of progressive glomerular injury.

My clinical research has focused on the immuopathology of lupus nephritis and in the pathogenesis of acute kidney injury.

Renal Disease, renal transport and ischemia, heat shock proteins, diabetic nephropathy, lupus nephritis, acute kidney injury, Electron Microscopy of tumors; juvenile diabetes. Cellular disruption and restitution. Diabetes.

Medical Subject Headings (MeSH)

Cells; Disorders of Environmental Origin; Epithelial Cells; Kidney; Kidney Glomerulus; Kidney Tubules; Lupus Nephritis; Mixed Connective Tissue Disease; Nephrons; Podocytes; Scleroderma, Systemic; Systemic Vasculitis

Research at a Glance

Yale Co-Authors

Frequent collaborators of Michael Kashgarian's published research.

Publications

2024

2022

2021

2020

Academic Achievements & Community Involvement

  • honor

    William Barriss McAllister Jr. Memorial Lecture for Excellence in Surgical Pathology

  • honor

    Robert Heptinstall Life Time Achievement Award

  • honor

    Medal of the Postgraduate Medical Institute

  • honor

    Jacob Churg Award

  • honor

    Elected Honorary Member

Get In Touch

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