Chen Liu, MD, PhD
Anthony N. Brady Professor of PathologyDownloadHi-Res Photo
Cards
Additional Titles
Chair, Pathology
Chief, YNHH Pathology
Administrative Support
Publications Overview
- 307 Publications
- 16,471 Citations
- 2 Yale Co-Authors
Additional Titles
Chair, Pathology
Chief, YNHH Pathology
Administrative Support
Publications Overview
- 307 Publications
- 16,471 Citations
- 2 Yale Co-Authors
Additional Titles
Chair, Pathology
Chief, YNHH Pathology
Administrative Support
Publications Overview
- 307 Publications
- 16,471 Citations
- 2 Yale Co-Authors
About
Titles
Anthony N. Brady Professor of Pathology
Chair, Pathology; Chief, YNHH Pathology
Biography
Dr. Liu is an expert in viral hepatitis, liver cancer immunotherapy, graft-versus-host disease, and cancer epigenetics. He currently serves as the Chair of the Department of Pathology and Chief of Pathology at Yale New Haven Hospital. He is also Anthony N. Brady Professor of Pathology.
After obtaining his medical degree at Tong Liao Medical College and completing his postgraduate training at Peking Union Medical College in China, Dr. Liu received his PhD in pathology from the University of Pennsylvania School of Medicine. He completed his residency in anatomical and clinical pathology at the Medical College of Pennsylvania, followed by an oncological pathology fellowship at M.D. Anderson Cancer Hospital. Additionally, he underwent postdoctoral training at Scripps Clinic.
Dr. Liu joined the faculty at the University of Florida's Department of Pathology, Immunology, and Laboratory Medicine, where he advanced to the positions of endowed professor and vice chair. In 2015, he was appointed as the joint chair of the Department of Pathology, Immunology, and Laboratory Medicine at New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University. He was recruited to Yale in 2020.
Appointments
Other Departments & Organizations
- Center for Gastrointestinal Cancers
- Chen Liu Lab
- Gastrointestinal (GI) & Liver Pathology
- Genomics, Genetics, and Epigenetics
- Hepatic Arterial Infusion (HAI) Program
- Hyperthermic intraperitoneal chemotherapy (HIPEC) Program
- Liver Cancer Program
- Molecular Medicine, Pharmacology, and Physiology
- Oligometastatic Cancer Program
- Pathology
- Yale Cancer Center
- Yale Center for Genomic Health
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- YSM Biobank
Education & Training
- PhD
- University of Pennsylvania School of Medicine, Pathology (1993)
- MD
- Tong Liao Medical College, Medicine (1980)
Research
Overview
Medical Research Interests
Immunotherapy
ORCID
0009-0003-0430-6146
Research at a Glance
Yale Co-Authors
Frequent collaborators of Chen Liu's published research.
Publications Timeline
A big-picture view of Chen Liu's research output by year.
Amy Ogurick, MD
Lohith Gowda, MD, MRCP
307Publications
16,471Citations
Publications
2023
A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
Chen Y, Lin X, Zou X, Qian Y, Liu Y, Wang R, Wang X, Yu X, Liu C, Cheng H. A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma. BMC Gastroenterology 2023, 23: 113. PMID: 37024802, PMCID: PMC10080823, DOI: 10.1186/s12876-023-02748-w.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTumor-infiltrating immune cellsExpression of OX40Risk score modelImmune cellsIdentified OX40Immune checkpointsOverall survivalScoring systemRisk scoreClinical specimensExpression of immune checkpoint genesCD8+ T cellsImmune checkpoint gene expressionSomatic mutationsProtein expressionHigh-risk score groupImmunogenic cell deathCheckpoint gene expressionImmune checkpoint expressionImmune checkpoint genesImmune cell infiltrationNaive B cellsCox regression analysisAssociated with increased survival ratesRisk scoring systemAmbient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation
Seike K, Kiledal A, Fujiwara H, Henig I, Burgos da Silva M, van den Brink M, Hein R, Hoostal M, Liu C, Oravecz-Wilson K, Lauder E, Li L, Sun Y, Schmidt T, Shah Y, Jenq R, Dick G, Reddy P. Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation. Immunity 2023, 56: 353-368.e6. PMID: 36736321, DOI: 10.1016/j.immuni.2023.01.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGraft-versus-host diseaseAmbient oxygen levelsGI graft-versus-host diseaseGut microbiome compositionMicrobiome-dependent mannerMicrobiome compositionMicrobial structureOxygen levelsIntestinal dysbiosisGraft-versus-host disease severityDysbiosisAllogeneic stem cell transplantationAnaerobic commensalsPathogenic T cellsStem cell transplantationIntestinal diseaseInflammatory bowel diseaseGastrointestinal (GI) diseasesCell transplantationIntestinal pathologyT cellsHostBowel diseaseHIF-1aIntestinal damageAssessing emotional characteristics in Asian autistic adults without intellectual disability
Chien Y, Liu C, Chiu Y, Lin C. Assessing emotional characteristics in Asian autistic adults without intellectual disability. Asian Journal Of Psychiatry 2023, 82: 103472. PMID: 36682157, DOI: 10.1016/j.ajp.2023.103472.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSchutte Emotional Intelligence ScaleAutistic adultsIntellectual disabilityEmotion perceptionSelf-reportEmotional Intelligence ScaleIntelligence ScaleMothers' reportsAutistic malesAutistic featuresEmotional characteristicsSchizophreniaEmotional featuresEmotionsAdultsDisabilitySchuttePerceptionScaleDifficultiesMale
2022
Esophageal Graft-vs-Host Disease Presenting as Esophagitis Dissecans Superficialis
Ogurick A, Liu C, Gowda L, Li D. Esophageal Graft-vs-Host Disease Presenting as Esophagitis Dissecans Superficialis. ACG Case Reports Journal 2022, 9: e00833. DOI: 10.14309/crj.0000000000000833.Peer-Reviewed Original ResearchAltmetricNiacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship
Yu Y, Su H, Lin S, Hsiao P, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Kuo C, Hwu H, Chen W. Niacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship. Schizophrenia 2022, 8: 38. PMID: 35853900, PMCID: PMC9261101, DOI: 10.1038/s41537-022-00252-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSchizophrenia patientsMembrane polyunsaturated fatty acidsNiacin skin testFlushing responseArachidonic acid levelsArachidonic acidFollow-upIncreased turnover of arachidonic acidSkin testFlush scorePolyunsaturated fatty acidsVulnerability to schizophreniaTurnover of arachidonic acidDihomo-gamma-linolenic acidSchizophrenia inpatientsPartial remissionSchizophreniaAcute exacerbationSkin flushingHealthy controlsControl-to-case ratioPatientsPersistent decreaseDocosahexaenoic acidIncreased turnoverError patterns of facial emotion recognition in patients with schizophrenia
Lee S, Lin G, Shih C, Chen K, Liu C, Kuo C, Hsieh C. Error patterns of facial emotion recognition in patients with schizophrenia. Journal Of Affective Disorders 2022, 300: 441-448. PMID: 34979185, DOI: 10.1016/j.jad.2021.12.130.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFacial emotion recognitionNegative emotionsError patternsDifferentiation of facesDiscrimination of facesEmotion recognitionHealthy adultsHappy facesResponse biasSchizophreniaTraditional confusion matrixBasic emotionsFacial expressionsEmotionsMethodological issuesAdultsFaceDeficitsFindingsConfusion matrixCliniciansDiscriminationIndividualsInterventionRecognition
2021
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills G, Sun C, Chen G. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Journal Of Experimental Medicine 2021, 219: e20210789. PMID: 34825915, PMCID: PMC8628262, DOI: 10.1084/jem.20210789.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsA549 CellsAnimalsAntineoplastic Combined Chemotherapy ProtocolsCD8-Positive T-LymphocytesCell Cycle ProteinsCell Line, TumorEndogenous RetrovirusesEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansImmune Checkpoint InhibitorsMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDNeoplasms, ExperimentalProtein-Tyrosine KinasesPyrazolesPyrimidinonesRNA, Double-StrandedSignal TransductionTumor BurdenConceptsImmune checkpoint blockadeAnti-tumor immunityEndogenous retroviral elementsWEE1 inhibitionCheckpoint blockadeCD8+ T cell-dependent mannerSensitivity to immune checkpoint blockadeResponse to immune checkpoint blockadeAnti-tumor T cellsCombination of WEE1 inhibitorT cell-dependent mannerPathway-targeted therapiesMultiple tumor modelsPopulation of patientsEmergence of resistanceDown-regulating FoxM1Viral defense pathwaysPD-L1Tumor regressionCombination therapyTargeted therapyCombination partnerT cellsPatient selectionWEE1 inhibitorImmune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd
Takashima S, Sharma R, Egorova A, Kuttiyara J, Ito T, Chang W, Jansen S, Liu C, Lindemans C, Mazutis L, Robine N, Hanash A. Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd. Blood 2021, 138: 86-86. DOI: 10.1182/blood-2021-152647.Peer-Reviewed Original ResearchConceptsIntestinal stem cellsGene set enrichment analysisMYC expressionIFNG treatmentSTAT1-dependent mannerActivating myc expressionDownstream of Wnt signalingInduced epithelial apoptosisInhibitor 10058-F4Intestinal stem cell maintenanceMYC inhibitor 10058-F4Single cell RNA sequencingIFNG signalingIntestinal stem cell populationIntestinal cryptsCell RNA sequencingGene expression profilesCell cycle analysisUpregulated transcription factorsWnt target gene Axin2Myc functionUpregulation of cyclin D1Sequenced cellsMYC pathwayPhenotypic distancesA quarter of century after: The changing ecology of psychiatric emergency services
Chen W, Hsieh M, Liao S, Liu C, Liu C, Wu C, Lin Y, Hwang T, Chien Y. A quarter of century after: The changing ecology of psychiatric emergency services. Asia-Pacific Psychiatry 2021, 14: e12487. PMID: 34510765, DOI: 10.1111/appy.12487.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMental disordersPsychiatry consultationSuicide/self-harmStressor-related disordersEmergency psychiatric servicesEmergency psychiatry serviceClinical data of genderCommon mental disordersSchizophrenia spectrumEmergency departmentPsychotic disordersDepressive disorderBipolar disorderPsychiatric servicesPsychiatry servicesPsychiatric emergenciesDisordersClinical trainingPsychiatryNeurosisChief complaintED visitsSchizophreniaMedical CenterData of genderThe Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer
Wang Z, Xiao R, Huang J, Qin X, Hu D, Guo E, Liu C, Lu F, You L, Sun C, Chen G. The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer. Microbial Ecology 2021, 84: 302-313. PMID: 34405250, DOI: 10.1007/s00248-021-01800-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLocally advanced cervical cancerLocally advanced cervical cancer patientsPlatinum-based chemotherapy responseAdvanced cervical cancerCervical cancerChemotherapy responseAlpha diversityVaginal microbiotaVaginal samplesCC patientsVaginal microbiomeHealthy controlsPredicting neoadjuvant chemotherapy responsePlatinum-resistant patientsNeoadjuvant chemotherapy responseAssociated with platinum-based chemotherapy responseCervical cancer patientsVaginal microbiota diversityNeoadjuvant chemotherapyHPV infectionBeta diversityBacteroides genusChemotherapy effectCancer patientsBacteroides abundance
Academic Achievements & Community Involvement
activity Practice & Management Committee
Advisory BoardsChairDetailsAssociation of Pathology Chairs (APC)2020 - Present
Clinical Care
Fact Sheets
Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Learn More on Yale MedicineGastrointestinal Cancers
Learn More on Yale Medicine
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2000
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News
- November 13, 2024
Public School Students Explore Careers at Annual Yale Pathology Day
- September 25, 2024
David Klimstra, MD, Joins Yale School of Medicine as a Professor of Pathology
- April 17, 2024
Demetrios Braddock, MD, PhD, Named Recipient of 2024 Harrington Discovery Institute Scholar-Innovator Award
- March 20, 2024
Digital pathology