Skip to Main Content

Andrew Miranker, PhD

Professor of Molecular Biophysics and Biochemistry and of Chemical and Environmental Engineering
DownloadHi-Res Photo

About

Titles

Professor of Molecular Biophysics and Biochemistry and of Chemical and Environmental Engineering

Appointments

Education & Training

PhD
Harvard University (1992)

Research

Overview

Research in our laboratory is focused on conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils. This folding problem is particularly fascinating as proteins which are seemingly unrelated in primary sequence and in their native 3 dimensional structure form aggregates which share common structural features. Depending on the protein involved, fibril formation gives rise or contributes to the pathogenesis of more than 20 clinical conditions. Projects currently underway in the laboratory include the islet amyloid polypeptide system which forms fibrils in the pancreas of type II diabetics, and beta-2 microglobulin which forms deposits on the connective tissues of long term dialysis patients. We are studying both the folding and the fibrillogenesis properties of these systems. Biophysical techniques enable these investigations to be conducted at a molecular level. These include high field NMR, optical spectroscopy and electrospray ionization mass spectrometry.

Research at a Glance

Yale Co-Authors

Frequent collaborators of Andrew Miranker's published research.

Publications

2023

2009

Get In Touch